OPS2_DROPS
ID OPS2_DROPS Reviewed; 381 AA.
AC P28679; Q298F1;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Opsin Rh2;
DE AltName: Full=Ocellar opsin;
GN Name=Rh2; ORFNames=GA14120;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Apple Hill;
RX PubMed=1398053; DOI=10.1093/genetics/132.1.193;
RA Carulli J.P., Hartl D.L.;
RT "Variable rates of evolution among Drosophila opsin genes.";
RL Genetics 132:193-204(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=420 nm;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Some or all of the Ser/Thr residues present in the C-terminal part
CC may be phosphorylated.
CC -!- MISCELLANEOUS: Opsin Rh2 is the predominant opsin expressed in the
CC dorsal ocelli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL28004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X65878; CAA46709.1; -; Genomic_DNA.
DR EMBL; CM000070; EAL28004.1; ALT_SEQ; Genomic_DNA.
DR PIR; S40692; S40692.
DR RefSeq; XP_001358861.1; XM_001358824.3.
DR AlphaFoldDB; P28679; -.
DR SMR; P28679; -.
DR STRING; 7237.FBpp0284042; -.
DR EnsemblMetazoa; FBtr0285604; FBpp0284042; FBgn0012708.
DR GeneID; 4801828; -.
DR KEGG; dpo:Dpse_GA14120; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; P28679; -.
DR OMA; FYYETWI; -.
DR PhylomeDB; P28679; -.
DR ChiTaRS; Rh2; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0012708; Expressed in insect adult head.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001735; Opsin_RH1/RH2.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00576; OPSINRH1RH2.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..381
FT /note="Opsin Rh2"
FT /id="PRO_0000197626"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT TRANSMEM 57..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..93
FT /note="Cytoplasmic"
FT TRANSMEM 94..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..133
FT /note="Extracellular"
FT TRANSMEM 134..153
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..172
FT /note="Cytoplasmic"
FT TRANSMEM 173..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..220
FT /note="Extracellular"
FT TRANSMEM 221..248
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..283
FT /note="Cytoplasmic"
FT TRANSMEM 284..307
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..314
FT /note="Extracellular"
FT TRANSMEM 315..339
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..381
FT /note="Cytoplasmic"
FT REGION 358..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 326
FT /note="N6-(retinylidene)lysine"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 130..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 45
FT /note="Y -> H (in Ref. 1; CAA46709)"
FT /evidence="ECO:0000305"
FT CONFLICT 342..343
FT /note="KY -> ND (in Ref. 1; CAA46709)"
FT /evidence="ECO:0000305"
FT CONFLICT 358
FT /note="S -> T (in Ref. 1; CAA46709)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="A -> D (in Ref. 1; CAA46709)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 42733 MW; 2033C05C4503FEAF CRC64;
MERSLLPEPP LAMALLGPRF EAQTGGNRSV LDNVLPDMAP LVNPYWSRFA PMDPTMSKIL
GLFTLVILII SCCGNGVVVY IFGGTKSLRT PANLLVLNLA FSDFCMMASQ SPVMIINFYY
ETWVLGPLWC DIYAACGSLF GCVSIWSMCM IAFDRYNVIV KGINGTPMTI KTSIMKIAFI
WMMAVFWTIM PLIGWSSYVP EGNLTACSID YMTRQWNPRS YLITYSLFVY YTPLFMICYS
YWFIIATVAA HEKAMRDQAK KMNVKSLRSS EDCDKSAENK LAKVALTTIS LWFMAWTPYL
IICYFGLFKI DGLTPLTTIW GATFAKTSAV YNPIVYGISH PKYRLVLKEK CPMCVCGSTD
EPKPDAPPSD TETTSEAESK A
