ID   AS1AA_XENLA             Reviewed;         201 AA.
AC   Q69DB9; B7ZR80;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Histone chaperone asf1a-A;
DE   AltName: Full=Anti-silencing function protein 1 homolog;
DE            Short=XAsf1;
DE   AltName: Full=Anti-silencing function protein 1 homolog A-A;
GN   Name=asf1aa; Synonyms=asf1, asf1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH HIRA AND P60.
RC   TISSUE=Oocyte;
RX   PubMed=17576589; DOI=10.1007/s00412-007-0112-x;
RA   Ray-Gallet D., Quivy J.P., Sillje H.W., Nigg E.A., Almouzni G.;
RT   "The histone chaperone Asf1 is dispensable for direct de novo histone
RT   deposition in Xenopus egg extracts.";
RL   Chromosoma 116:487-496(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and disassembly
CC       (By similarity). Not critical for histone deposition during nucleosome
CC       assembly (PubMed:17576589). {ECO:0000250|UniProtKB:Q9Y294,
CC       ECO:0000269|PubMed:17576589}.
CC   -!- SUBUNIT: Interacts with histone H3 (including both histone H3.1 and
CC       H3.3) and histone H4 (By similarity). Interacts with hira and p60
CC       (PubMed:17576589). {ECO:0000250|UniProtKB:Q9Y294,
CC       ECO:0000269|PubMed:17576589}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y294}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; AY351903; AAR08148.1; -; mRNA.
DR   EMBL; BC170073; AAI70073.1; -; mRNA.
DR   EMBL; BC170075; AAI70075.1; -; mRNA.
DR   RefSeq; NP_001086449.1; NM_001092980.1.
DR   AlphaFoldDB; Q69DB9; -.
DR   BMRB; Q69DB9; -.
DR   SMR; Q69DB9; -.
DR   BioGRID; 103120; 2.
DR   GeneID; 446260; -.
DR   KEGG; xla:446260; -.
DR   CTD; 446260; -.
DR   Xenbase; XB-GENE-949299; asf1a.L.
DR   OMA; INWEENT; -.
DR   OrthoDB; 1334998at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 446260; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..201
FT                   /note="Histone chaperone asf1a-A"
FT                   /id="PRO_0000284020"
SQ   SEQUENCE   201 AA;  22837 MW;  36ACE97E958721F3 CRC64;
     MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV
     LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET
     ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEENTEKL DDSNPHMHPV LSIEARPSAS
     KGWPMSENSL NVMLESHMDC M