OPS3_DROPS
ID OPS3_DROPS Reviewed; 382 AA.
AC P28680; Q294E9; Q8I1B3;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Opsin Rh3;
DE AltName: Full=Inner R7 photoreceptor cells opsin;
GN Name=Rh3; ORFNames=GA10619;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Apple Hill;
RX PubMed=1398053; DOI=10.1093/genetics/132.1.193;
RA Carulli J.P., Hartl D.L.;
RT "Variable rates of evolution among Drosophila opsin genes.";
RL Genetics 132:193-204(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tucson 14011-0121.4;
RX PubMed=12537575; DOI=10.1186/gb-2002-3-12-research0086;
RA Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A., Gnirke A.,
RA Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M., Park S., Stapleton M.,
RA Wan K.H., George R.A., de Jong P.J., Botas J., Rubin G.M., Celniker S.E.;
RT "Assessing the impact of comparative genomic sequence data on the
RT functional annotation of the Drosophila genome.";
RL Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or
CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the
CC R1 to R6 cells are outer cells, while R7 and R8 are inner cells.
CC -!- MISCELLANEOUS: Opsin Rh3 is sensitive to UV light.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL29015.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X65879; CAA46710.1; -; Genomic_DNA.
DR EMBL; AY190949; AAO01058.1; -; Genomic_DNA.
DR EMBL; CM000070; EAL29015.2; ALT_SEQ; Genomic_DNA.
DR PIR; S40693; S40693.
DR RefSeq; XP_001359863.3; XM_001359826.3.
DR AlphaFoldDB; P28680; -.
DR SMR; P28680; -.
DR IntAct; P28680; 1.
DR STRING; 7237.FBpp0284809; -.
DR EnsemblMetazoa; FBtr0286371; FBpp0284809; FBgn0012709.
DR GeneID; 4803062; -.
DR KEGG; dpo:Dpse_GA10619; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P28680; -.
DR ChiTaRS; Rh3; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0012709; Expressed in insect adult head.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0016039; P:absorption of UV light; IEA:EnsemblMetazoa.
DR GO; GO:0007604; P:phototransduction, UV; IEA:EnsemblMetazoa.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000856; Opsin_RH3/RH4.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00577; OPSINRH3RH4.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..382
FT /note="Opsin Rh3"
FT /id="PRO_0000197628"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT TRANSMEM 57..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..93
FT /note="Cytoplasmic"
FT TRANSMEM 94..118
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..132
FT /note="Extracellular"
FT TRANSMEM 133..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..170
FT /note="Cytoplasmic"
FT TRANSMEM 171..195
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..219
FT /note="Extracellular"
FT TRANSMEM 220..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..283
FT /note="Cytoplasmic"
FT TRANSMEM 284..307
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..315
FT /note="Extracellular"
FT TRANSMEM 316..340
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..382
FT /note="Cytoplasmic"
FT MOD_RES 327
FT /note="N6-(retinylidene)lysine"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 129..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 365
FT /note="A -> R (in Ref. 1; CAA46710)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 382 AA; 42844 MW; AF8C48BDC0031774 CRC64;
MEYHNVSSVL GNVSSVLRPD ARLSAESRLL GWNVPPDELR HIPEHWLIYP EPPESMNYLL
GTLYIFFTVI SMIGNGLVMW VFSAAKSLRT PSNILVINLA FCDFMMMIKT PIFIYNSFHQ
GYALGHLGCQ IFGVIGSYTG IAAGATNAFI AYDRYNVITR PMEGKMTHGK AIAMIIFIYL
YATPWVVACY TESWGRFVPE GYLTSCTFDY LTDNFDTRLF VACIFFFSFV CPTTMITYYY
SQIVGHVFSH EKALRDQAKK MNVDSLRSNV DKSKEAAEIR IAKAAITICF LFFASWTPYG
VMSLIGAFGD KTLLTPGATM IPACTCKMVA CIDPFVYAIS HPRYRMELQK RCPWLAISEK
APESAAAIST STTQEQQQTT AA
