OPS4_DROPS
ID OPS4_DROPS Reviewed; 380 AA.
AC P29404; B5DR64;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Opsin Rh4;
DE AltName: Full=Inner R7 photoreceptor cells opsin;
GN Name=Rh4; ORFNames=GA28288;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Apple Hill;
RX PubMed=1398053; DOI=10.1093/genetics/132.1.193;
RA Carulli J.P., Hartl D.L.;
RT "Variable rates of evolution among Drosophila opsin genes.";
RL Genetics 132:193-204(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- MISCELLANEOUS: Each Drosophila eye is composed of 800 facets or
CC ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the
CC R1 to R6 cells are outer cells, while R7 and R8 are inner cells.
CC -!- MISCELLANEOUS: Opsin Rh4 is sensitive to UV light.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X65880; CAA46711.1; -; Genomic_DNA.
DR EMBL; X65881; CAA46711.1; JOINED; Genomic_DNA.
DR EMBL; CH379070; EDY74117.1; -; Genomic_DNA.
DR PIR; S65545; S65545.
DR RefSeq; XP_002135490.1; XM_002135454.2.
DR AlphaFoldDB; P29404; -.
DR SMR; P29404; -.
DR STRING; 7237.FBpp0286219; -.
DR EnsemblMetazoa; FBtr0287781; FBpp0286219; FBgn0012710.
DR GeneID; 6900151; -.
DR KEGG; dpo:Dpse_GA28288; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; P29404; -.
DR OMA; GCQIFAA; -.
DR ChiTaRS; Rh4; fly.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0012710; Expressed in insect adult head and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0007604; P:phototransduction, UV; IEA:EnsemblMetazoa.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000856; Opsin_RH3/RH4.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00577; OPSINRH3RH4.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..380
FT /note="Opsin Rh4"
FT /id="PRO_0000197631"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT TRANSMEM 55..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..91
FT /note="Cytoplasmic"
FT TRANSMEM 92..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..130
FT /note="Extracellular"
FT TRANSMEM 131..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..168
FT /note="Cytoplasmic"
FT TRANSMEM 169..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..217
FT /note="Extracellular"
FT TRANSMEM 218..245
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..281
FT /note="Cytoplasmic"
FT TRANSMEM 282..305
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..313
FT /note="Extracellular"
FT TRANSMEM 314..338
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..380
FT /note="Cytoplasmic"
FT REGION 359..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 325
FT /note="N6-(retinylidene)lysine"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 127..204
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 224
FT /note="F -> L (in Ref. 1; CAA46711)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="C -> V (in Ref. 1; CAA46711)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="D -> E (in Ref. 1; CAA46711)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 42942 MW; 4875C89C429B0D48 CRC64;
MDALCNASEP PLRPEARMSS GSDELQFLGW NVPPDQIQYI PEHWLTQLEP PASMHYMLGV
FYIFLFFAST LGNGMVIWIF STSKSLRTPS NMFVLNLAVF DLIMCLKAPI FIYNSFHRGF
ALGNTWCQIF ASIGSYSGIG AGMTNAAIGY DRYNVITKPM NRNMTFTKAV IMNIIIWLYC
TPWVVLPLTQ FWDRFVPEGY LTSCSFDYLS DNFDTRLFVG TIFFFSFVCP TLMILYYYSQ
IVGHVFNHEK ALREQAKKMN VESLRSNVDK SKETAEIRIA KAAITICFLF FVSWTPYGVM
SLIGAFGDKS LLTPGATMIP ACTCKLVACI DPFVYAISHP RYRMELQKRC PWLGVNEKSG
EASSAQSTTT QEQTQQTSAA
