OPSB_BOVIN
ID OPSB_BOVIN Reviewed; 349 AA.
AC P51490;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Short-wave-sensitive opsin 1;
DE AltName: Full=Blue cone photoreceptor pigment;
DE AltName: Full=Blue-sensitive opsin;
DE Short=BOP;
GN Name=OPN1SW; Synonyms=BCP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BG18;
RX PubMed=8088841; DOI=10.1006/geno.1994.1292;
RA Chiu M.I., Zack D.J., Wang Y., Nathans J.;
RT "Murine and bovine blue cone pigment genes: cloning and characterization of
RT two new members of the S family of visual pigments.";
RL Genomics 21:440-443(1994).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal (By similarity). Required for the maintenance of cone
CC outer segment organization in the ventral retina, but not essential for
CC the maintenance of functioning cone photoreceptors (By similarity).
CC Involved in ensuring correct abundance and localization of retinal
CC membrane proteins (By similarity). May increase spectral sensitivity in
CC dim light (By similarity). {ECO:0000250|UniProtKB:P03999,
CC ECO:0000250|UniProtKB:P51491}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P03999};
CC Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment
CC {ECO:0000250|UniProtKB:P51491}. Cell projection, cilium, photoreceptor
CC outer segment {ECO:0000250|UniProtKB:P51491}. Cytoplasm, perinuclear
CC region {ECO:0000250|UniProtKB:P03999}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U49764; AAA93189.1; -; Genomic_DNA.
DR EMBL; U49760; AAA93189.1; JOINED; Genomic_DNA.
DR EMBL; U49761; AAA93189.1; JOINED; Genomic_DNA.
DR EMBL; U49762; AAA93189.1; JOINED; Genomic_DNA.
DR EMBL; U49763; AAA93189.1; JOINED; Genomic_DNA.
DR EMBL; U92557; AAB50158.1; -; mRNA.
DR PIR; A54679; A54679.
DR RefSeq; NP_776992.1; NM_174567.1.
DR AlphaFoldDB; P51490; -.
DR SMR; P51490; -.
DR STRING; 9913.ENSBTAP00000021912; -.
DR PaxDb; P51490; -.
DR Ensembl; ENSBTAT00000021912; ENSBTAP00000021912; ENSBTAG00000016485.
DR GeneID; 282294; -.
DR KEGG; bta:282294; -.
DR CTD; 611; -.
DR VEuPathDB; HostDB:ENSBTAG00000016485; -.
DR VGNC; VGNC:32436; OPN1SW.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234549; -.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; P51490; -.
DR OMA; CLCYVPY; -.
DR OrthoDB; 940057at2759; -.
DR TreeFam; TF324998; -.
DR Reactome; R-BTA-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Reactome; R-BTA-419771; Opsins.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000016485; Expressed in retina and 6 other tissues.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0071492; P:cellular response to UV-A; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001521; Opsin_blue.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00574; OPSINBLUE.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Chromophore; Cytoplasm; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1..349
FT /note="Short-wave-sensitive opsin 1"
FT /id="PRO_0000197761"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT TRANSMEM 35..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT TRANSMEM 72..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..111
FT /note="Extracellular"
FT TRANSMEM 112..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..150
FT /note="Cytoplasmic"
FT TRANSMEM 151..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..200
FT /note="Extracellular"
FT TRANSMEM 201..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..250
FT /note="Cytoplasmic"
FT TRANSMEM 251..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..282
FT /note="Extracellular"
FT TRANSMEM 283..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..349
FT /note="Cytoplasmic"
FT REGION 327..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 294
FT /note="N6-(retinylidene)lysine"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 108..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 349 AA; 39302 MW; A71C2B7B5750EC4A CRC64;
MSKMSEEEEF LLFKNISLVG PWDGPQYHLA PVWAFHLQAV FMGFVFFVGT PLNATVLVAT
LRYRKLRQPL NYILVNVSLG GFIYCIFSVF IVFITSCYGY FVFGRHVCAL EAFLGCTAGL
VTGWSLAFLA FERYIIICKP FGNFRFSSKH ALMVVVATWT IGIGVSIPPF FGWSRFVPEG
LQCSCGPDWY TVGTKYYSEY YTWFLFIFCY IVPLSLICFS YSQLLGALRA VAAQQQESAS
TQKAEREVSH MVVVMVGSFC LCYTPYAALA MYIVNNRNHG VDLRLVTIPA FFSKSACVYN
PIIYCFMNKQ FRACIMEMVC GKPMTDESEL SSSQKTEVST VSSSQVGPN
