OPSB_SAIBB
ID OPSB_SAIBB Reviewed; 349 AA.
AC O13092;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Short-wave-sensitive opsin 1;
DE AltName: Full=Blue cone photoreceptor pigment;
DE AltName: Full=Blue-sensitive opsin;
DE Short=BOP;
GN Name=OPN1SW; Synonyms=BCP;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9089077; DOI=10.1007/pl00006157;
RA Shimmin L.C., Mai P., Li W.H.;
RT "Sequences and evolution of human and squirrel monkey blue opsin genes.";
RL J. Mol. Evol. 44:378-382(1997).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal (By similarity). Required for the maintenance of cone
CC outer segment organization in the ventral retina, but not essential for
CC the maintenance of functioning cone photoreceptors (By similarity).
CC Involved in ensuring correct abundance and localization of retinal
CC membrane proteins (By similarity). May increase spectral sensitivity in
CC dim light (By similarity). {ECO:0000250|UniProtKB:P03999,
CC ECO:0000250|UniProtKB:P51491}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=420 nm;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P03999};
CC Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment
CC {ECO:0000250|UniProtKB:P51491}. Cell projection, cilium, photoreceptor
CC outer segment {ECO:0000250|UniProtKB:P51491}. Cytoplasm, perinuclear
CC region {ECO:0000250|UniProtKB:P03999}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U53875; AAC51335.1; -; Genomic_DNA.
DR RefSeq; XP_003921059.1; XM_003921010.2.
DR AlphaFoldDB; O13092; -.
DR SMR; O13092; -.
DR STRING; 39432.ENSSBOP00000010602; -.
DR Ensembl; ENSSBOT00000027379; ENSSBOP00000010602; ENSSBOG00000022139.
DR GeneID; 101046045; -.
DR KEGG; sbq:101046045; -.
DR CTD; 611; -.
DR GeneTree; ENSGT01030000234549; -.
DR OMA; CLCYVPY; -.
DR OrthoDB; 940057at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0097381; C:photoreceptor disc membrane; IEA:UniProt.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0071492; P:cellular response to UV-A; ISS:UniProtKB.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001521; Opsin_blue.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00574; OPSINBLUE.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Chromophore; Cytoplasm; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1..349
FT /note="Short-wave-sensitive opsin 1"
FT /id="PRO_0000197765"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 294
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 108..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 349 AA; 39123 MW; 30E40603F4FD2F2F CRC64;
MSKMPEEEEF YLFKNISSVG PWDGPQYHIA PVWAFQLQAA FMGIVFLAGL PLNSMVLVAT
VRYKKLRHPL NYVLVNVSVG GFLLCIFSVL PVFVNSCNGY FVFGRHVCAL EGFLGTVAGL
VTGWSLAFLA FERYIVICKP FGNFRFSSKH ALMVVLTTWT IGIGVSIPPF FGWSRYIAEG
LQCSCGPDWY TVGTKYRSEY YTWFLFIFCF IVPLSLICFS YAQLLRALKA VAAQQQESAT
TQKAEREVSR MVVVMVGSFC VCYVPYAALA MYMVNNRNHG LDLRLVSIPA FFSKSSCIYN
PIIYCFMNKQ FRACIMEMVC GKAMTDESDI SSSQKTEVST VSSSQVGPN
