AS1_ARATH
ID AS1_ARATH Reviewed; 367 AA.
AC O80931; Q53YQ1;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Transcription factor AS1 {ECO:0000303|PubMed:11140682};
DE AltName: Full=Myb-related protein 91 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB91 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Protein ASYMMETRIC LEAVES 1 {ECO:0000303|PubMed:11140682};
DE AltName: Full=Protein PHANTASTICA {ECO:0000303|PubMed:10102816};
DE Short=AtPHAN {ECO:0000303|PubMed:10102816};
GN Name=AS1 {ECO:0000303|PubMed:11140682};
GN Synonyms=MYB91 {ECO:0000303|PubMed:9839469},
GN PHAN {ECO:0000303|PubMed:10102816};
GN OrderedLocusNames=At2g37630 {ECO:0000312|Araport:AT2G37630};
GN ORFNames=F13M22.13 {ECO:0000312|EMBL:AAC23633.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND FUNCTION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11140682; DOI=10.1038/35050091;
RA Byrne M.E., Barley R., Curtis M., Arroyo J.M., Dunham M., Hudson A.,
RA Martienssen R.A.;
RT "ASYMMETRIC LEAVES1 mediates leaf patterning and stem cell function in
RT Arabidopsis.";
RL Nature 408:967-971(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, AND FUNCTION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11882937; DOI=10.1007/s004250100673;
RA Sun Y., Zhou Q., Zhang W., Fu Y., Huang H.;
RT "ASYMMETRIC LEAVES1, an Arabidopsis gene that is involved in the control of
RT cell differentiation in leaves.";
RL Planta 214:694-702(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L.-J., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [7]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clone.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP IDENTIFICATION.
RX PubMed=10102816; DOI=10.1126/science.284.5411.151;
RA Timmermans M.C.P., Hudson A., Becraft P.W., Nelson T.;
RT "ROUGH SHEATH2: a Myb protein that represses knox homeobox genes in maize
RT lateral organ primordia.";
RL Science 284:151-153(1999).
RN [10]
RP FUNCTION.
RX PubMed=11076771; DOI=10.1242/dev.127.24.5523;
RA Ori N., Eshed Y., Chuck G., Bowman J.L., Hake S.;
RT "Mechanisms that control knox gene expression in the Arabidopsis shoot.";
RL Development 127:5523-5532(2000).
RN [11]
RP CHARACTERIZATION.
RX PubMed=11934861; DOI=10.1242/dev.129.8.1957;
RA Byrne M.E., Simorowski J., Martienssen R.A.;
RT "ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis.";
RL Development 129:1957-1965(2002).
RN [12]
RP FUNCTION, AND SUBUNIT.
RX PubMed=12750468; DOI=10.1073/pnas.1132113100;
RA Theodoris G., Inada N., Freeling M.;
RT "Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC
RT LEAVES1 function in leaf development.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:6837-6842(2003).
RN [13]
RP INTERACTION WITH LBD6/AS2.
RX PubMed=12874130; DOI=10.1242/dev.00622;
RA Xu L., Xu Y., Dong A., Sun Y., Pi L., Xu Y., Huang H.;
RT "Novel as1 and as2 defects in leaf adaxial-abaxial polarity reveal the
RT requirement for ASYMMETRIC LEAVES1 and 2 and ERECTA functions in specifying
RT leaf adaxial identity.";
RL Development 130:4097-4107(2003).
RN [14]
RP INTERACTION WITH HIRA; RIK AND LBD6/AS2.
RX PubMed=16243907; DOI=10.1105/tpc.105.035477;
RA Phelps-Durr T.L., Thomas J., Vahab P., Timmermans M.C.P.;
RT "Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1
RT interact with HIRA, a predicted histone chaperone, to maintain knox gene
RT silencing and determinacy during organogenesis.";
RL Plant Cell 17:2886-2898(2005).
RN [15]
RP INDUCTION.
RX PubMed=16166385; DOI=10.1101/gad.352005;
RA Chua Y.L., Channeliere S., Mott E., Gray J.C.;
RT "The bromodomain protein GTE6 controls leaf development in Arabidopsis by
RT histone acetylation at ASYMMETRIC LEAVES1.";
RL Genes Dev. 19:2245-2254(2005).
RN [16]
RP FUNCTION.
RX PubMed=16006579; DOI=10.1105/tpc.105.033449;
RA Li H., Xu L., Wang H., Yuan Z., Cao X., Yang Z., Zhang D., Xu Y., Huang H.;
RT "The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with
RT ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in
RT Arabidopsis leaf development.";
RL Plant Cell 17:2157-2171(2005).
RN [17]
RP FUNCTION.
RX PubMed=16699177; DOI=10.1093/pcp/pcj057;
RA Xu L., Yang L., Pi L., Liu Q., Ling Q., Wang H., Poethig R.S., Huang H.;
RT "Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for
RT leaf morphogenesis.";
RL Plant Cell Physiol. 47:853-863(2006).
RN [18]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [19]
RP FUNCTION.
RX PubMed=17395603; DOI=10.1093/pcp/pcm040;
RA Fu Y., Xu L., Xu B., Yang L., Ling Q., Wang H., Huang H.;
RT "Genetic interactions between leaf polarity-controlling genes and
RT ASYMMETRIC LEAVES1 and 2 in Arabidopsis leaf patterning.";
RL Plant Cell Physiol. 48:724-735(2007).
RN [20]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17559509; DOI=10.1111/j.1365-313x.2007.03132.x;
RA Iwakawa H., Iwasaki M., Kojima S., Ueno Y., Soma T., Tanaka H.,
RA Semiarti E., Machida Y., Machida C.;
RT "Expression of the ASYMMETRIC LEAVES2 gene in the adaxial domain of
RT Arabidopsis leaves represses cell proliferation in this domain and is
RT critical for the development of properly expanded leaves.";
RL Plant J. 51:173-184(2007).
RN [21]
RP FUNCTION, INTERACTION WITH HDA6 AND LBD6, AND SUBCELLULAR LOCATION.
RX PubMed=23271976; DOI=10.1371/journal.pgen.1003114;
RA Luo M., Yu C.W., Chen F.F., Zhao L., Tian G., Liu X., Cui Y., Yang J.Y.,
RA Wu K.;
RT "Histone deacetylase HDA6 is functionally associated with AS1 in repression
RT of KNOX genes in arabidopsis.";
RL PLoS Genet. 8:E1003114-E1003114(2012).
RN [22]
RP FUNCTION, INTERACTION WITH CO, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=21950734; DOI=10.1111/j.1365-313x.2011.04793.x;
RA Song Y.H., Lee I., Lee S.Y., Imaizumi T., Hong J.C.;
RT "CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of
RT FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis.";
RL Plant J. 69:332-342(2012).
RN [23]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27334696; DOI=10.1242/bio.019109;
RA Matsumura Y., Ohbayashi I., Takahashi H., Kojima S., Ishibashi N., Keta S.,
RA Nakagawa A., Hayashi R., Saez-Vasquez J., Echeverria M., Sugiyama M.,
RA Nakamura K., Machida C., Machida Y.;
RT "A genetic link between epigenetic repressor AS1-AS2 and a putative small
RT subunit processome in leaf polarity establishment of Arabidopsis.";
RL Biol. Open 5:942-954(2016).
CC -!- FUNCTION: Transcription factor required for normal cell
CC differentiation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB)
CC within the shoot apex, and the class III HD-ZIP genes REV, PHB, and
CC PHV. Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress
CC the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial
CC determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the
CC RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to
CC regulate the leaf morphogenesis (PubMed:11076771, PubMed:11140682,
CC PubMed:11882937, PubMed:12750468, PubMed:16006579, PubMed:16699177,
CC PubMed:17395603, PubMed:17559509, PubMed:23271976). Binds directly to
CC KNAT1, KNAT2, and KNATM chromatin, regulating leaf development
CC (PubMed:23271976). LBD6 is required for this binding (PubMed:23271976).
CC Positive regulator of flowering that binds to the promoter of FT
CC (PubMed:21950734). Regulates FT expression by forming a functional
CC complex with CO (PubMed:21950734). Involved in leaf polarity
CC establishment by functioning cooperatively with NUCL1 to repress
CC abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox
CC homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial
CC development in leaf primordia at shoot apical meristems at high
CC temperatures (PubMed:27334696). {ECO:0000269|PubMed:11076771,
CC ECO:0000269|PubMed:11140682, ECO:0000269|PubMed:11882937,
CC ECO:0000269|PubMed:12750468, ECO:0000269|PubMed:16006579,
CC ECO:0000269|PubMed:16699177, ECO:0000269|PubMed:17395603,
CC ECO:0000269|PubMed:17559509, ECO:0000269|PubMed:23271976,
CC ECO:0000269|PubMed:27334696}.
CC -!- SUBUNIT: Homodimer (PubMed:12750468, PubMed:23271976). Heterodimer with
CC LBD6 (PubMed:23271976). Interacts with LBD6/AS2, HIRA, a probable
CC histone chaperone, and RIK, a predicted RNA binding protein
CC (PubMed:12874130, PubMed:16243907). Part of the AS1 repressor complex
CC composed of AS1, LBD6/AS2 and HDA6 (PubMed:23271976). Interacts with CO
CC (PubMed:21950734). {ECO:0000269|PubMed:12750468,
CC ECO:0000269|PubMed:12874130, ECO:0000269|PubMed:16243907,
CC ECO:0000269|PubMed:21950734, ECO:0000269|PubMed:23271976}.
CC -!- INTERACTION:
CC O80931; Q9FLI3: AHG1; NbExp=3; IntAct=EBI-763232, EBI-2363348;
CC O80931; Q8L9Y3: ARR14; NbExp=3; IntAct=EBI-763232, EBI-1100737;
CC O80931; O80931: AS1; NbExp=3; IntAct=EBI-763232, EBI-763232;
CC O80931; O04479: AS2; NbExp=4; IntAct=EBI-763232, EBI-4443304;
CC O80931; A0A178W725: AXX17_At1g45300; NbExp=3; IntAct=EBI-763232, EBI-25515760;
CC O80931; Q9SQI2: GI; NbExp=3; IntAct=EBI-763232, EBI-446380;
CC O80931; Q9LUC3: MPK19; NbExp=3; IntAct=EBI-763232, EBI-25512843;
CC O80931; Q9SJG9: MPK20; NbExp=3; IntAct=EBI-763232, EBI-2358896;
CC O80931; O23160: MYB73; NbExp=3; IntAct=EBI-763232, EBI-25506855;
CC O80931; P11035: NIA2; NbExp=4; IntAct=EBI-763232, EBI-4451150;
CC O80931; Q38845: PP2AA1; NbExp=3; IntAct=EBI-763232, EBI-1645478;
CC O80931; Q1H5E9: PRDA1; NbExp=3; IntAct=EBI-763232, EBI-1998055;
CC O80931; Q8RY59: RCD1; NbExp=2; IntAct=EBI-763232, EBI-2118043;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23271976}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers,
CC siliques and in lateral organ promordia (PubMed:17559509). Found in the
CC inner domain between the adaxial and abaxial domains of leaves
CC (PubMed:17559509). Expressed in the phloem tissues of leaves,
CC cotyledons, hypocotyls, and roots (PubMed:21950734).
CC {ECO:0000269|PubMed:17559509, ECO:0000269|PubMed:21950734}.
CC -!- DEVELOPMENTAL STAGE: Preferential expression in young and immature
CC plant tissues. In embryos, expressed from the late globular stage
CC onwards. After germination, detected in leaf founder cells and on
CC flowering, in primordia of all floral organs.
CC -!- INDUCTION: Circadian-regulation with an afternoon peak in long days and
CC with a broad night peak in short days (PubMed:21950734). Expression of
CC AS1 in stem cells of the shoot apical meristem is prevented by SHOOT
CC MERISTEMLESS (STM). Expression is activated by GTE6 during leaf
CC morphogenesis (PubMed:16166385). {ECO:0000269|PubMed:16166385,
CC ECO:0000269|PubMed:21950734}.
CC -!- DOMAIN: A C-terminal domain (252-356) is required for dimerization.
CC -!- DISRUPTION PHENOTYPE: Plants with double mutations in this protein and
CC in RH10 or AS2 protein have abaxialized filamentous and trumpet-like
CC leaves at high temperatures. In double mutants, shapes of epidermal
CC cells of the filamentous leaves are simple and rectangular, similar to
CC those of a petiole, but different from those of flat leaves of wild-
CC type plants. {ECO:0000269|PubMed:27334696}.
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DR EMBL; AF175996; AAD53101.1; -; mRNA.
DR EMBL; AY519578; AAS10048.1; -; mRNA.
DR EMBL; AC004684; AAC23633.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09428.1; -; Genomic_DNA.
DR EMBL; BT026027; ABG48383.1; -; mRNA.
DR PIR; T02529; T02529.
DR RefSeq; NP_181299.1; NM_129319.4.
DR AlphaFoldDB; O80931; -.
DR SMR; O80931; -.
DR BioGRID; 3684; 28.
DR IntAct; O80931; 17.
DR STRING; 3702.AT2G37630.1; -.
DR PaxDb; O80931; -.
DR PRIDE; O80931; -.
DR ProteomicsDB; 246911; -.
DR EnsemblPlants; AT2G37630.1; AT2G37630.1; AT2G37630.
DR GeneID; 818340; -.
DR Gramene; AT2G37630.1; AT2G37630.1; AT2G37630.
DR KEGG; ath:AT2G37630; -.
DR Araport; AT2G37630; -.
DR TAIR; locus:2040671; AT2G37630.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_864276_0_0_1; -.
DR InParanoid; O80931; -.
DR OMA; RMKRVEM; -.
DR OrthoDB; 959551at2759; -.
DR PhylomeDB; O80931; -.
DR PRO; PR:O80931; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80931; baseline and differential.
DR Genevisible; O80931; AT.
DR GO; GO:0000793; C:condensed chromosome; IDA:TAIR.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IPI:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0008356; P:asymmetric cell division; IMP:TAIR.
DR GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0010338; P:leaf formation; IGI:TAIR.
DR GO; GO:0009965; P:leaf morphogenesis; IMP:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IMP:TAIR.
DR GO; GO:0009946; P:proximal/distal axis specification; IMP:TAIR.
DR GO; GO:0045088; P:regulation of innate immune response; IMP:TAIR.
DR GO; GO:0009615; P:response to virus; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Flowering; Nucleus; Reference proteome; Repeat;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..367
FT /note="Transcription factor AS1"
FT /id="PRO_0000197073"
FT DOMAIN 1..53
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 54..108
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 27..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 81..104
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT COILED 260..344
FT /evidence="ECO:0000255"
SQ SEQUENCE 367 AA; 42243 MW; 24D9085193E6088B CRC64;
MKERQRWSGE EDALLRAYVR QFGPREWHLV SERMNKPLNR DAKSCLERWK NYLKPGIKKG
SLTEEEQRLV IRLQEKHGNK WKKIAAEVPG RTAKRLGKWW EVFKEKQQRE EKESNKRVEP
IDESKYDRIL ESFAEKLVKE RSNVVPAAAA AATVVMANSN GGFLHSEQQV QPPNPVIPPW
LATSNNGNNV VARPPSVTLT LSPSTVAAAA PQPPIPWLQQ QQPERAENGP GGLVLGSMMP
SCSGSSESVF LSELVECCRE LEEGHRAWAD HKKEAAWRLR RLELQLESEK TCRQREKMEE
IEAKMKALRE EQKNAMEKIE GEYREQLVGL RRDAEAKDQK LADQWTSRHI RLTKFLEQQM
GCRLDRP