OPSD_SPHSP
ID OPSD_SPHSP Reviewed; 376 AA.
AC P35362;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Rhodopsin;
DE Short=Opsin;
OS Sphodromantis sp. (Mantis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Mantodea; Eumantodea; Mantoidea;
OC Mantidae; Mantinae; Paramantini; Sphodromantis; unclassified Sphodromantis.
OX NCBI_TaxID=27433;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8206378; DOI=10.1016/0378-1119(94)90101-5;
RA Towner P., Gaertner W.;
RT "The primary structure of mantid opsin.";
RL Gene 143:227-231(1994).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X71665; CAA50658.1; -; mRNA.
DR PIR; S34335; S34335.
DR AlphaFoldDB; P35362; -.
DR SMR; P35362; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR001391; Opsin_lateye.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00578; OPSINLTRLEYE.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 2: Evidence at transcript level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix;
KW Vision.
FT CHAIN 1..376
FT /note="Rhodopsin"
FT /id="PRO_0000197642"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..191
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..302
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..376
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 353..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 321
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 376 AA; 41883 MW; 4D0A271CC1F7B82B CRC64;
MSLINEPSYS AYSWGGQGGY GNQTVVDKVL PEMLHLIDPH WYQFPPMNPL WHGLLGFVIG
CLGFVSVVGN GMVIYIFSTT KGLRTPSNLL VVNLAFSDFL MMLSMSPPMV INCYYETWVL
GPFMCELYAL LGSLFGCGSI WTMVMIALDR YNVIVKGLAA KPMTNKTAML RILGIWAMSI
AWTVFPLFGW NRYVPEGNMT ACGTDYLNKE WVSRSYILVY SVFVYFLPLA TIIYSYWFIV
QAVSAHEKQM REQAKKMNVA SLRSAENANT SAECKLAKVA LMTISLWFFA WTPYLVTDFS
GIFEWGKISP LATIWCSLFA KANAVYNPIV YGISHPKYRA ALNKKFPSLA CASEPDDTAS
QASGATTVSD EKSASA
