OPSR1_DANRE
ID OPSR1_DANRE Reviewed; 357 AA.
AC Q9W6A7; Q9PWN3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Red-sensitive opsin-1;
DE AltName: Full=Opsin-1, long-wave-sensitive 1;
DE Short=Opsin LWS-1;
DE AltName: Full=Red cone photoreceptor pigment 1;
GN Name=opn1lw1; Synonyms=lws1, rdops;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Retina;
RX PubMed=8924413; DOI=10.1017/s0952523800009457;
RA Robinson J., Schmitt E.A., Dowling J.E.;
RT "Temporal and spatial patterns of opsin gene expression in zebrafish (Danio
RT rerio).";
RL Vis. Neurosci. 12:895-906(1995).
RN [2]
RP ERRATUM OF PUBMED:8924413.
RX PubMed=10349978; DOI=10.1017/s0952523899163181;
RA Schmitt E.A., Hyatt G.A., Dowling J.E.;
RL Vis. Neurosci. 16:601-605(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Eye;
RX PubMed=10349976; DOI=10.1017/s0952523899163168;
RA Vihtelic T.S., Doro C.J., Hyde D.R.;
RT "Cloning and characterization of six zebrafish photoreceptor opsin cDNAs
RT and immunolocalization of their corresponding proteins.";
RL Vis. Neurosci. 16:571-585(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND BIOPHYSICOCHEMICAL
RP PROPERTIES.
RC STRAIN=AB; TISSUE=Eye;
RX PubMed=12618404; DOI=10.1093/genetics/163.2.663;
RA Chinen A., Hamaoka T., Yamada Y., Kawamura S.;
RT "Gene duplication and spectral diversification of cone visual pigments of
RT zebrafish.";
RL Genetics 163:663-675(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=558 nm {ECO:0000269|PubMed:12618404};
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Retinal double cone principal photoreceptor cell
CC outer segments. {ECO:0000269|PubMed:10349976}.
CC -!- DEVELOPMENTAL STAGE: First detected in the retina at 51 hours post
CC fertilization (hpf) along the nasal edge of the choroid fissure. By 55
CC hpf expression has extended into the nasal region and by 72 hpf it
CC covers the whole retina. {ECO:0000269|PubMed:8924413}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF104904; AAD20549.1; -; mRNA.
DR EMBL; AF109371; AAD24754.1; -; mRNA.
DR EMBL; AB087803; BAC24127.1; -; Genomic_DNA.
DR EMBL; BC059415; AAH59415.1; -; mRNA.
DR RefSeq; NP_001300644.1; NM_001313715.1.
DR AlphaFoldDB; Q9W6A7; -.
DR SMR; Q9W6A7; -.
DR STRING; 7955.ENSDARP00000065940; -.
DR PaxDb; Q9W6A7; -.
DR Ensembl; ENSDART00000065941; ENSDARP00000065940; ENSDARG00000044862.
DR GeneID; 30413; -.
DR KEGG; dre:30413; -.
DR CTD; 30413; -.
DR ZFIN; ZDB-GENE-990604-41; opn1lw1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234549; -.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; Q9W6A7; -.
DR OMA; EWGKQSF; -.
DR OrthoDB; 940057at2759; -.
DR PhylomeDB; Q9W6A7; -.
DR TreeFam; TF324998; -.
DR Reactome; R-DRE-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Reactome; R-DRE-419771; Opsins.
DR PRO; PR:Q9W6A7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 11.
DR Bgee; ENSDARG00000044862; Expressed in head and 4 other tissues.
DR ExpressionAtlas; Q9W6A7; baseline.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0009883; F:red or far-red light photoreceptor activity; NAS:UniProtKB.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0009648; P:photoperiodism; IDA:ZFIN.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0009416; P:response to light stimulus; IDA:ZFIN.
DR GO; GO:0007601; P:visual perception; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..357
FT /note="Red-sensitive opsin-1"
FT /id="PRO_0000197793"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..74
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 309
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 283
FT /note="Missing (in Ref. 1; AAD20549)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 39888 MW; 295BA8BA27013ACD CRC64;
MAEHWGDAIY AARRKGDETT REAMFTYTNS NNTKDPFEGP NYHIAPRWVY NVATVWMFFV
VVASTFTNGL VLVATAKFKK LRHPLNWILV NLAIADLGET LFASTISVIN QFFGYFILGH
PMCIFEGYTV SVCGIAALWS LTVISWERWV VVCKPFGNVK FDAKWASAGI IFSWVWAAAW
CAPPIFGWSR YWPHGLKTSC GPDVFSGSED PGVQSYMVVL MITCCIIPLA IIILCYIAVY
LAIHAVAQQQ KDSESTQKAE KEVSRMVVVM IFAYCFCWGP YTFFACFAAA NPGYAFHPLA
AAMPAYFAKS ATIYNPVIYV FMNRQFRVCI MQLFGKKVDD GSEVSTSKTE VSSVAPA
