OPSR_BOVIN
ID OPSR_BOVIN Reviewed; 364 AA.
AC Q9BGI7;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Long-wave-sensitive opsin 1;
DE AltName: Full=Red cone photoreceptor pigment;
DE AltName: Full=Red-sensitive opsin;
GN Name=OPN1LW; Synonyms=RCP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fauser S., Luberichs J.F., Ferreira P.A.;
RT "Cloning of the red visual pigment gene of Bos taurus.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, AND GLYCOSYLATION
RP AT SER-22 AND ASN-34.
RX PubMed=30948514; DOI=10.1074/jbc.ra118.006835;
RA Salom D., Jin H., Gerken T.A., Yu C., Huang L., Palczewski K.;
RT "Human red and green cone opsins are O-glycosylated at an N-terminal
RT Ser/Thr-rich domain conserved in vertebrates.";
RL J. Biol. Chem. 294:8123-8133(2019).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in retina (at protein level)
CC (PubMed:30948514). Expressed in cone and/or rod photoreceptor cells (at
CC protein level) (PubMed:30948514). {ECO:0000269|PubMed:30948514}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF280398; AAG49893.1; -; mRNA.
DR RefSeq; NP_776991.1; NM_174566.1.
DR AlphaFoldDB; Q9BGI7; -.
DR SMR; Q9BGI7; -.
DR STRING; 9913.ENSBTAP00000027054; -.
DR iPTMnet; Q9BGI7; -.
DR PaxDb; Q9BGI7; -.
DR Ensembl; ENSBTAT00000027054; ENSBTAP00000027054; ENSBTAG00000020299.
DR GeneID; 282293; -.
DR KEGG; bta:282293; -.
DR CTD; 5956; -.
DR VEuPathDB; HostDB:ENSBTAG00000020299; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234549; -.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; Q9BGI7; -.
DR OMA; EWGKQSF; -.
DR OrthoDB; 940057at2759; -.
DR TreeFam; TF324998; -.
DR Reactome; R-BTA-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Reactome; R-BTA-419771; Opsins.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000020299; Expressed in retina and 13 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..364
FT /note="Long-wave-sensitive opsin 1"
FT /id="PRO_0000245019"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT TRANSMEM 53..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..89
FT /note="Cytoplasmic"
FT TRANSMEM 90..115
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..129
FT /note="Extracellular"
FT TRANSMEM 130..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..168
FT /note="Cytoplasmic"
FT TRANSMEM 169..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..218
FT /note="Extracellular"
FT TRANSMEM 219..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..268
FT /note="Cytoplasmic"
FT TRANSMEM 269..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..300
FT /note="Extracellular"
FT TRANSMEM 301..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..364
FT /note="Cytoplasmic"
FT MOD_RES 312
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000269|PubMed:30948514"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:30948514"
FT DISULFID 126..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 364 AA; 40584 MW; 8810194D27D1F53F CRC64;
MAHAWGPQRL AGGQPQANFE ESTQGSIFTY TNSNSTRDPF EGPNYHIAPR WVYHLTSAWM
VFVVIASVFT NGLVLAATMR FKKLRHPLNW ILVNLAIADL AETIIASTIS VVNQMYGYFV
LGHPLCVVEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAI TGIAFSWIWA
AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMITCCFI PLSVIILCYL
QVWLAIRAVA KQQKESESTQ KAEKEVTRMV MVMIFAYCLC WGPYTFFACF AAAHPGYAFH
PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDSSELSSV SKTEASSVSS
VSPA
