OPSR_CAPHI
ID OPSR_CAPHI Reviewed; 364 AA.
AC Q95170;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Long-wave-sensitive opsin 1;
DE AltName: Full=Red cone photoreceptor pigment;
DE AltName: Full=Red-sensitive opsin;
GN Name=OPN1LW; Synonyms=RCP;
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9370283; DOI=10.1016/s0378-1119(97)00316-8;
RA Radlwimmer F.B., Yokoyama S.;
RT "Cloning and expression of the red visual pigment gene of goat (Capra
RT hircus).";
RL Gene 198:211-215(1997).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=553 nm;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone
CC photoreceptor cells.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U68004; AAC48773.1; -; Genomic_DNA.
DR EMBL; U67999; AAC48773.1; JOINED; Genomic_DNA.
DR EMBL; U68000; AAC48773.1; JOINED; Genomic_DNA.
DR EMBL; U68001; AAC48773.1; JOINED; Genomic_DNA.
DR EMBL; U68002; AAC48773.1; JOINED; Genomic_DNA.
DR EMBL; U68003; AAC48773.1; JOINED; Genomic_DNA.
DR RefSeq; XP_005701795.1; XM_005701738.2.
DR AlphaFoldDB; Q95170; -.
DR SMR; Q95170; -.
DR STRING; 9925.ENSCHIP00000014220; -.
DR Ensembl; ENSCHIT00000022014; ENSCHIP00000014220; ENSCHIG00000015283.
DR GeneID; 102175286; -.
DR KEGG; chx:102175286; -.
DR GeneTree; ENSGT01030000234549; -.
DR OrthoDB; 940057at2759; -.
DR Proteomes; UP000291000; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..364
FT /note="Long-wave-sensitive opsin 1"
FT /id="PRO_0000197799"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT TRANSMEM 53..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..89
FT /note="Cytoplasmic"
FT TRANSMEM 90..115
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..129
FT /note="Extracellular"
FT TRANSMEM 130..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..168
FT /note="Cytoplasmic"
FT TRANSMEM 169..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..218
FT /note="Extracellular"
FT TRANSMEM 219..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..268
FT /note="Cytoplasmic"
FT TRANSMEM 269..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..300
FT /note="Extracellular"
FT TRANSMEM 301..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..364
FT /note="Cytoplasmic"
FT MOD_RES 312
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000250|UniProtKB:Q9BGI7"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 126..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 364 AA; 40572 MW; 19664C5313A40E96 CRC64;
MAHTWGPQRL AGGQPQANFE ESTQGSIFTY TNSNSTRDPF EGPNYHIAPR WVYHLTSAWM
VFVVIASVFT NGLVLAATMR FKKLRHPLNW ILVNLAIADL AETIIASTIS VVNQMYGYFV
LGHPLCVVEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAT AGIAFSWIWA
AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMITCCFI PLSVIILCYL
QVWLAIRAVA KQQKESESTQ KAEKEVTRMV MVMIFAYCLC WGPYTFFACF AAAHPGYAFH
PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDSSELSSV SKTEASSVSS
VSPA
