OPSR_HORSE
ID OPSR_HORSE Reviewed; 364 AA.
AC O18912; Q9TU70;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Long-wave-sensitive opsin 1;
DE AltName: Full=Red cone photoreceptor pigment;
DE AltName: Full=Red-sensitive opsin;
GN Name=OPN1LW; Synonyms=RCP;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1] {ECO:0000312|EMBL:AAD30524.1}
RP NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, AND TISSUE
RP SPECIFICITY.
RX PubMed=10511567; DOI=10.1093/genetics/153.2.919;
RA Yokoyama S., Radlwimmer F.B.;
RT "The molecular genetics of red and green color vision in mammals.";
RL Genetics 153:919-932(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 48-320.
RX PubMed=9580985; DOI=10.1093/oxfordjournals.molbev.a025956;
RA Yokoyama S., Radlwimmer F.B.;
RT "The 'five-sites' rule and the evolution of red and green color vision in
RT mammals.";
RL Mol. Biol. Evol. 15:560-567(1998).
RN [3] {ECO:0000312|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000312|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=545 nm {ECO:0000269|PubMed:10511567};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: The three color pigments are found in the cone
CC photoreceptor cells. Expressed in retina (PubMed:10511567).
CC {ECO:0000269|PubMed:10511567}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF132043; AAD30524.1; -; mRNA.
DR EMBL; AF031531; AAB86634.1; -; mRNA.
DR RefSeq; NP_001075314.1; NM_001081845.1.
DR AlphaFoldDB; O18912; -.
DR SMR; O18912; -.
DR STRING; 9796.ENSECAP00000016460; -.
DR PaxDb; O18912; -.
DR Ensembl; ENSECAT00000020072; ENSECAP00000016460; ENSECAG00000018684.
DR GeneID; 100033892; -.
DR KEGG; ecb:100033892; -.
DR CTD; 5956; -.
DR GeneTree; ENSGT01030000234549; -.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; O18912; -.
DR OMA; EWGKQSF; -.
DR OrthoDB; 940057at2759; -.
DR TreeFam; TF324998; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000018684; Expressed in retina and 2 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000378; Opsin_red/grn.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00575; OPSINREDGRN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..364
FT /note="Long-wave-sensitive opsin 1"
FT /id="PRO_0000197801"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 53..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 90..115
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..129
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 130..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..218
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 219..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..300
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 301..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MOD_RES 312
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000305"
FT CARBOHYD 22
FT /note="O-linked (GlcNAc) serine"
FT /evidence="ECO:0000250|UniProtKB:Q9BGI7"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 126..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 364 AA; 40450 MW; 3977E4544CE7F478 CRC64;
MAQRWGPQKL AGGQPQAGFE DSTQASIFTY TNNNATRDPF EGPNYHIAPR WVYHVTSAWM
IFVVIASVFT NGLVLAATMR FKKLRHPLNW ILVNLAVADL AETIIASTIS VVNQIYGYFV
LGHPMCVVEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAV AGIAFSWIWA
AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMITCCII PLSVIVLCYL
QVWLAIRAVA KQQKESESTQ KAEKEVTRMV MVMVFAFCLC WGPYTFFACF AAAHPGYAFH
PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDSSELSSV SKTEASSVSS
VSPA
