OPSUV_APIME
ID OPSUV_APIME Reviewed; 371 AA.
AC O61303; Q2YD68;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Opsin, ultraviolet-sensitive;
DE AltName: Full=UV-sensitive opsin;
DE Short=AmUVop;
DE Short=BUVOPS;
GN Name=UVOP;
OS Apis mellifera (Honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC Apis.
OX NCBI_TaxID=7460;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Head;
RX PubMed=9502802; DOI=10.1523/jneurosci.18-07-02412.1998;
RA Townson S.M., Chang B.S.W., Salcedo E., Chadwell L.V., Pierce N.E.,
RA Britt S.G.;
RT "Honeybee blue- and ultraviolet-sensitive opsins: cloning, heterologous
RT expression in Drosophila, and physiological characterization.";
RL J. Neurosci. 18:2412-2422(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH4;
RG Honey bee genome project;
RA Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16291092; DOI=10.1016/j.ibmb.2005.09.001;
RA Velarde R.A., Sauer C.D., Walden K.K.O., Fahrbach S.E., Robertson H.M.;
RT "Pteropsin: a vertebrate-like non-visual opsin expressed in the honey bee
RT brain.";
RL Insect Biochem. Mol. Biol. 35:1367-1377(2005).
CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC mediate vision. They consist of an apoprotein, opsin, covalently linked
CC to 11-cis-retinal.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Absorption:
CC Abs(max)=353 nm;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the dorsal region of the retina.
CC {ECO:0000269|PubMed:16291092}.
CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC present in the C-terminal region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF004169; AAC13418.1; -; mRNA.
DR EMBL; AADG06009813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK005513; DAA05738.1; -; Genomic_DNA.
DR RefSeq; NP_001011605.1; NM_001011605.1.
DR AlphaFoldDB; O61303; -.
DR SMR; O61303; -.
DR STRING; 7460.GB51369-PA; -.
DR PaxDb; O61303; -.
DR EnsemblMetazoa; NM_001011605; NP_001011605; GeneID_406127.
DR GeneID; 406127; -.
DR KEGG; ame:406127; -.
DR CTD; 406127; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; O61303; -.
DR OMA; VACYTES; -.
DR OrthoDB; 704940at2759; -.
DR PhylomeDB; O61303; -.
DR Proteomes; UP000005203; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IDA:CACAO.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR000856; Opsin_RH3/RH4.
DR InterPro; IPR027430; Retinal_BS.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR00577; OPSINRH3RH4.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..371
FT /note="Opsin, ultraviolet-sensitive"
FT /id="PRO_0000197639"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 318
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 371 AA; 41458 MW; 9B2BB1FF92762956 CRC64;
MSNDSIHWEA RYLPAGPPRL LGWNVPAEEL IHIPEHWLVY PEPNPSLHYL LALLYILFTF
LALLGNGLVI WIFCAAKSLR TPSNMFVVNL AICDFFMMIK TPIFIYNSFN TGFALGNLGC
QIFAVIGSLT GIGAAITNAA IAYDRYSTIA RPLDGKLSRG QVILFIVLIW TYTIPWALMP
VMGVWGRFVP EGFLTSCSFD YLTDTNEIRI FVATIFTFSY CIPMILIIYY YSQIVSHVVN
HEKALREQAK KMNVDSLRSN ANTSSQSAEI RIAKAAITIC FLYVLSWTPY GVMSMIGAFG
NKALLTPGVT MIPACTCKAV ACLDPYVYAI SHPKYRLELQ KRLPWLELQE KPISDSTSTT
TETVNTPPAS S
