ID   OPSUV_CARAU             Reviewed;         336 AA.
AC   Q90309;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Ultraviolet-sensitive opsin;
DE   AltName: Full=Ultraviolet cone photoreceptor pigment;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8736253; DOI=10.1016/0042-6989(95)00189-1;
RA   Hisatomi O., Satoh T., Barthel L.K., Stenkamp D.L., Raymond P.A.,
RA   Tokunaga F.;
RT   "Molecular cloning and characterization of the putative ultraviolet-
RT   sensitive visual pigment of goldfish.";
RL   Vision Res. 36:933-939(1996).
CC   -!- FUNCTION: Visual pigments are the light-absorbing molecules that
CC       mediate vision. They consist of an apoprotein, opsin, covalently linked
CC       to cis-retinal.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- PTM: Phosphorylated on some or all of the serine and threonine residues
CC       present in the C-terminal region. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D85863; BAA12889.1; -; mRNA.
DR   AlphaFoldDB; Q90309; -.
DR   SMR; Q90309; -.
DR   Ensembl; ENSCART00000085214; ENSCARP00000078852; ENSCARG00000037034.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001760; Opsin.
DR   InterPro; IPR001521; Opsin_blue.
DR   InterPro; IPR027430; Retinal_BS.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   PRINTS; PR00574; OPSINBLUE.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
PE   2: Evidence at transcript level;
KW   Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Photoreceptor protein; Receptor;
KW   Reference proteome; Retinal protein; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix; Vision.
FT   CHAIN           1..336
FT                   /note="Ultraviolet-sensitive opsin"
FT                   /id="PRO_0000197806"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT   TRANSMEM        30..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..66
FT                   /note="Cytoplasmic"
FT   TRANSMEM        67..91
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..106
FT                   /note="Extracellular"
FT   TRANSMEM        107..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..145
FT                   /note="Cytoplasmic"
FT   TRANSMEM        146..169
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..195
FT                   /note="Extracellular"
FT   TRANSMEM        196..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..245
FT                   /note="Cytoplasmic"
FT   TRANSMEM        246..269
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..277
FT                   /note="Extracellular"
FT   TRANSMEM        278..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..336
FT                   /note="Cytoplasmic"
FT   MOD_RES         289
FT                   /note="N6-(retinylidene)lysine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        103..180
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   336 AA;  37445 MW;  C0D763FD1AFC37C5 CRC64;
     MDAWTYQFGN LSKISPFEGP QYHLAPKWAF YLQAAFMGFV FFVGTPLNAI VLFVTMKYKK
     LRQPLNYILV NISLGGFIFD TFSVSQVFFS ALRGYYFFGY TLCAMEAAMG SIAGLVTGWS
     LAVLAFERYV VICKPFGSFK FGQSQALGAV ALTWIIGIGC ATPPFWGWSR YIPEGIGTAC
     GPDWYTKNEE YNTESYTYFL LVSCFMMPIM IITFSYSQLL GALRAVAAQQ AESASTQKAE
     KEVSRMVVVM VGSFVVCYGP YAITALYFSY AEDSNKDYRL VAIPSLFSKS SCVYNPLIYA
     FMNKQFNACI METVFGKKID ESSEVSSKTE TSSVSA