ID   OPSX_HAEIN              Reviewed;         347 AA.
AC   Q57336; O05014;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Lipopolysaccharide core heptosyltransferase OpsX {ECO:0000303|PubMed:16109967};
DE            EC=2.-.-.- {ECO:0000305};
GN   Name=opsX {ECO:0000303|PubMed:16109967}; OrderedLocusNames=HI_0261;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=16109967; DOI=10.1128/jb.187.17.6242-6247.2005;
RA   Gronow S., Brabetz W., Lindner B., Brade H.;
RT   "OpsX from Haemophilus influenzae represents a novel type of
RT   heptosyltransferase I in lipopolysaccharide biosynthesis.";
RL   J. Bacteriol. 187:6242-6247(2005).
CC   -!- FUNCTION: Catalyzes heptose transfer to the lipopolysaccharide core. It
CC       transfers the first L-glycero-D-manno-heptose to the phosphorylated 3-
CC       deoxy-alpha-D-manno-octulosonic acid (Kdo-P) of the inner core.
CC       {ECO:0000269|PubMed:16109967}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000305|PubMed:16109967}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 9 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21926.1; -; Genomic_DNA.
DR   PIR; B64058; B64058.
DR   RefSeq; NP_438430.1; NC_000907.1.
DR   RefSeq; WP_010868969.1; NC_000907.1.
DR   AlphaFoldDB; Q57336; -.
DR   SMR; Q57336; -.
DR   STRING; 71421.HI_0261; -.
DR   CAZy; GT9; Glycosyltransferase Family 9.
DR   DNASU; 950896; -.
DR   EnsemblBacteria; AAC21926; AAC21926; HI_0261.
DR   KEGG; hin:HI_0261; -.
DR   PATRIC; fig|71421.8.peg.276; -.
DR   eggNOG; COG0859; Bacteria.
DR   HOGENOM; CLU_038371_2_0_6; -.
DR   OMA; HMAVTQG; -.
DR   PhylomeDB; Q57336; -.
DR   BioCyc; HINF71421:G1GJ1-276-MON; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008713; F:ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008920; F:lipopolysaccharide heptosyltransferase activity; IDA:UniProtKB.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IBA:GO_Central.
DR   CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR   InterPro; IPR002201; Glyco_trans_9.
DR   Pfam; PF01075; Glyco_transf_9; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN           1..347
FT                   /note="Lipopolysaccharide core heptosyltransferase OpsX"
FT                   /id="PRO_0000207266"
SQ   SEQUENCE   347 AA;  38938 MW;  E2149186830B0461 CRC64;
     MPLFTEAPKS LCILRLSAVG DVCHALAVVQ HIQEYYPQTE MTWIVGKTEM GLLSSIPNIT
     LIPYDKKTGW KGVLSLWKQL KNKQFDALLN MQTAFRASIL SLGIKAKFKI GFGEKRSREG
     QWLFVNRRIR DPFSPHVLDG FMAFAEYIGV PKAEPKWELA ISQDDYKFAD QFIDFSRKNL
     LISPCSSKAE KDWLIEGYAE VANIAHQHNI NVIFCSSPAK RELEIVEKIT ALCHFTPTNI
     AGKTNLKQLT ALISKVDLVL SPDSGPAHIA TTQGTPVIGL YAYHNPLRTA PYNNLDNVVS
     VYEENAQKEF GKPSSELPWA TKLKGKNLMT EIQVEPVIGQ MKKLGLF