OPSX_MOUSE
ID OPSX_MOUSE Reviewed; 337 AA.
AC O35214;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Visual pigment-like receptor peropsin;
GN Name=Rrh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=9275222; DOI=10.1073/pnas.94.18.9893;
RA Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT "Peropsin, a novel visual pigment-like protein located in the apical
RT microvilli of the retinal pigment epithelium.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997).
CC -!- FUNCTION: May play a role in rpe physiology either by detecting light
CC directly or by monitoring the concentration of retinoids or other
CC photoreceptor-derived compounds.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Found only in the eye, where it is localized to the
CC retinal pigment epithelium (RPE). In the RPE, it is localized to the
CC microvilli that surround the photoreceptor outer segments.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF012271; AAC53344.1; -; mRNA.
DR CCDS; CCDS38633.1; -.
DR RefSeq; NP_033128.1; NM_009102.3.
DR AlphaFoldDB; O35214; -.
DR SMR; O35214; -.
DR BioGRID; 203021; 1.
DR STRING; 10090.ENSMUSP00000132360; -.
DR GlyGen; O35214; 2 sites.
DR iPTMnet; O35214; -.
DR PhosphoSitePlus; O35214; -.
DR PaxDb; O35214; -.
DR PRIDE; O35214; -.
DR ProteomicsDB; 294221; -.
DR Antibodypedia; 15375; 146 antibodies from 26 providers.
DR DNASU; 20132; -.
DR Ensembl; ENSMUST00000171313; ENSMUSP00000132360; ENSMUSG00000028012.
DR Ensembl; ENSMUST00000196902; ENSMUSP00000143093; ENSMUSG00000028012.
DR GeneID; 20132; -.
DR KEGG; mmu:20132; -.
DR UCSC; uc008ril.1; mouse.
DR CTD; 10692; -.
DR MGI; MGI:1097709; Rrh.
DR VEuPathDB; HostDB:ENSMUSG00000028012; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230391; -.
DR HOGENOM; CLU_009579_3_0_1; -.
DR InParanoid; O35214; -.
DR OMA; MHWNDSS; -.
DR OrthoDB; 704940at2759; -.
DR PhylomeDB; O35214; -.
DR TreeFam; TF324998; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-419771; Opsins.
DR BioGRID-ORCS; 20132; 2 hits in 74 CRISPR screens.
DR PRO; PR:O35214; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O35214; protein.
DR Bgee; ENSMUSG00000028012; Expressed in pigmented layer of retina and 27 other tissues.
DR ExpressionAtlas; O35214; baseline and differential.
DR Genevisible; O35214; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002962; Peropsin.
DR InterPro; IPR027430; Retinal_BS.
DR InterPro; IPR032972; RRH.
DR PANTHER; PTHR24240:SF77; PTHR24240:SF77; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01244; PEROPSIN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 1: Evidence at protein level;
KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Photoreceptor protein; Receptor; Reference proteome;
KW Retinal protein; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="Visual pigment-like receptor peropsin"
FT /id="PRO_0000197820"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT TRANSMEM 27..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..61
FT /note="Cytoplasmic"
FT TRANSMEM 62..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..101
FT /note="Extracellular"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT TRANSMEM 141..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..188
FT /note="Extracellular"
FT TRANSMEM 189..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..240
FT /note="Cytoplasmic"
FT TRANSMEM 241..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..272
FT /note="Extracellular"
FT TRANSMEM 273..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..337
FT /note="Cytoplasmic"
FT MOD_RES 284
FT /note="N6-(retinylidene)lysine"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 337 AA; 37209 MW; 353E4E2278EDBFA6 CRC64;
MLSEASDFNS SGSRSEGSVF SRTEHSVIAA YLIVAGITSI LSNVVVLGIF IKYKELRTPT
NAVIINLAFT DIGVSSIGYP MSAASDLHGS WKFGHAGCQI YAGLNIFFGM VSIGLLTVVA
MDRYLTISCP DVGRRMTTNT YLSMILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR
NNDTSFVSYT MMVIVVNFIV PLTVMFYCYY HVSRSLRLYA ASDCTAHLHR DWADQADVTK
MSVIMILMFL LAWSPYSIVC LWACFGNPKK IPPSMAIIAP LFAKSSTFYN PCIYVAAHKK
FRKAMLAMFK CQPHLAVPEP STLPMDMPQS SLAPVRI
