ID   OPT1_ARATH              Reviewed;         755 AA.
AC   Q9FG72;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Oligopeptide transporter 1;
DE            Short=AtOPT1;
GN   Name=OPT1; OrderedLocusNames=At5g55930; ORFNames=MYN21.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=11788749; DOI=10.1104/pp.010332;
RA   Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.;
RT   "An oligopeptide transporter gene family in Arabidopsis.";
RL   Plant Physiol. 128:21-29(2002).
CC   -!- FUNCTION: Involved in the translocation of tetra- and pentapeptides
CC       across the cellular membrane in an energy-dependent manner.
CC       {ECO:0000269|PubMed:11788749}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in flowers, and moderately
CC       expressed in leaves and stems. {ECO:0000269|PubMed:11788749}.
CC   -!- SIMILARITY: Belongs to the oligopeptide OPT transporter (TC 2.A.67.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AB026659; BAB08658.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96700.1; -; Genomic_DNA.
DR   EMBL; AY070725; AAL50067.1; -; mRNA.
DR   EMBL; BT004528; AAO42774.1; -; mRNA.
DR   RefSeq; NP_200404.1; NM_124975.4.
DR   AlphaFoldDB; Q9FG72; -.
DR   BioGRID; 20935; 24.
DR   IntAct; Q9FG72; 24.
DR   STRING; 3702.AT5G55930.1; -.
DR   PaxDb; Q9FG72; -.
DR   PRIDE; Q9FG72; -.
DR   ProteomicsDB; 248764; -.
DR   EnsemblPlants; AT5G55930.1; AT5G55930.1; AT5G55930.
DR   GeneID; 835691; -.
DR   Gramene; AT5G55930.1; AT5G55930.1; AT5G55930.
DR   KEGG; ath:AT5G55930; -.
DR   Araport; AT5G55930; -.
DR   TAIR; locus:2178398; AT5G55930.
DR   eggNOG; KOG2262; Eukaryota.
DR   HOGENOM; CLU_004965_1_1_1; -.
DR   InParanoid; Q9FG72; -.
DR   OMA; FKVYSTI; -.
DR   OrthoDB; 190227at2759; -.
DR   PhylomeDB; Q9FG72; -.
DR   PRO; PR:Q9FG72; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FG72; baseline and differential.
DR   Genevisible; Q9FG72; AT.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; ISS:TAIR.
DR   GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004648; Oligpept_transpt.
DR   InterPro; IPR004813; OPT.
DR   PANTHER; PTHR22601; PTHR22601; 1.
DR   Pfam; PF03169; OPT; 1.
DR   TIGRFAMs; TIGR00727; ISP4_OPT; 1.
DR   TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peptide transport; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..755
FT                   /note="Oligopeptide transporter 1"
FT                   /id="PRO_0000213778"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        546..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        614..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        664..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        697..717
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   755 AA;  85349 MW;  4404990DC9F6D5A2 CRC64;
     MTSVFDEHKP SDDSHESKIV INGEEEVLEE ENDNPIEEVR LTVPITDDPT LPVLTFRTWT
     LGLFSCILLA FVNQFFGFRS NQLWVSSVAA QIVTLPLGKL MAKTLPTKKF GFPGTNWSWS
     FNPGPFNMKE HVLITIFANT GAGGVYATSI ITIVKAFYNR QLNVAAAMLL TQTTQLLGYG
     WAGIFRKFLV DSPYMWWPSN LVQVSLFRAL HEKEDLQKGQ QTRFRFFIIV FCVSFAYYII
     PGYLFPSISA ISFVCWIWKS SVTAQIVGSG LKGLGIGSFG LDWSTVAGFL GSPLAVPFFA
     IANFFGGFFI FLYIVLPIFY WTNAYDAQKF PFYTSHTFDQ TGHTYNITRI LNEKNFDINL
     DAYNGYSKLY LSVMFALLYG LSFGSLCATI SHVALYDGKF IWGMWKKAKT ATKDKYGDVH
     SRLMKKNYQS VPQWWFIAVL VISFAFALYA CEGFDKQLQL PWWGLILACA IALFFTLPIG
     VIQATTNQQM GLNVITELII GYLYPGKPLA NVAFKTYGYI SMSQALYFVG DFKLGHYMKI
     PPRSMFIVQL VATVVASTVC FGTTWWLITS VENICNVDLL PVGSPWTCPG DEVFYNASII
     WGVIGPGRMF TKEGIYPGMN WFFLIGLLAP VPFWYLSKKF PEKKWLKQIH VPLIFSAVSA
     MPQAKAVHYW SWAIVGVVFN YYIFRRFKTW WARHNYILSA ALDAGTAIMG VLIFFAFQNN
     DISLPDWWGL ENSDHCPLAH CPLAKGVVVE GCPVF