OPT6_ARATH
ID OPT6_ARATH Reviewed; 736 AA.
AC Q9T095;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Oligopeptide transporter 6;
DE Short=AtOPT6;
GN Name=OPT6; OrderedLocusNames=At4g27730; ORFNames=T29A15.220;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=11788749; DOI=10.1104/pp.010332;
RA Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.;
RT "An oligopeptide transporter gene family in Arabidopsis.";
RL Plant Physiol. 128:21-29(2002).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=15247401; DOI=10.1104/pp.104.039859;
RA Cagnac O., Bourbouloux A., Chakrabarty D., Zhang M.Y., Delrot S.;
RT "AtOPT6 transports glutathione derivatives and is induced by
RT primisulfuron.";
RL Plant Physiol. 135:1378-1387(2004).
CC -!- FUNCTION: Involved in the translocation of tetra- and pentapeptides
CC across the cellular membrane in an energy-dependent manner. Also
CC involved in transport of glutathione derivatives and metal complexes,
CC and may be involved in stress resistance. {ECO:0000269|PubMed:11788749,
CC ECO:0000269|PubMed:15247401}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers and roots, and at a low level
CC in leaves and stems. Detected in the cambial zone of the vascular
CC bundles and in the region of lateral root initiation. Low expression in
CC the vascular network of the petals and high in the stamen filaments and
CC the gynoecium. {ECO:0000269|PubMed:11788749,
CC ECO:0000269|PubMed:15247401}.
CC -!- DEVELOPMENTAL STAGE: In young embryos, transient expression in the
CC procambium and, at later stage, expression over the whole surface of
CC the embryo and in the inner tegument, in the area adjacent to the
CC micropyle. {ECO:0000269|PubMed:15247401}.
CC -!- INDUCTION: Induced by primisulfuron and abscisic acid, and weakly by
CC 2,4-dichlorophenoxyacetic acid (2,4-D). Not induced by salicylic acid,
CC hydrogen peroxide, reduced and oxidized glutathione or cadmium.
CC {ECO:0000269|PubMed:15247401}.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter (TC 2.A.67.1)
CC family. {ECO:0000305}.
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DR EMBL; AL035602; CAB38285.1; -; Genomic_DNA.
DR EMBL; AL161571; CAB81423.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85386.1; -; Genomic_DNA.
DR EMBL; AY142525; AAN13068.1; -; mRNA.
DR PIR; T05878; T05878.
DR RefSeq; NP_194503.1; NM_118912.6.
DR AlphaFoldDB; Q9T095; -.
DR STRING; 3702.AT4G27730.1; -.
DR PaxDb; Q9T095; -.
DR PRIDE; Q9T095; -.
DR ProteomicsDB; 248820; -.
DR EnsemblPlants; AT4G27730.1; AT4G27730.1; AT4G27730.
DR GeneID; 828887; -.
DR Gramene; AT4G27730.1; AT4G27730.1; AT4G27730.
DR KEGG; ath:AT4G27730; -.
DR Araport; AT4G27730; -.
DR TAIR; locus:2137727; AT4G27730.
DR eggNOG; KOG2262; Eukaryota.
DR HOGENOM; CLU_004965_1_1_1; -.
DR InParanoid; Q9T095; -.
DR OMA; RSMFRAQ; -.
DR OrthoDB; 190227at2759; -.
DR PhylomeDB; Q9T095; -.
DR PRO; PR:Q9T095; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T095; baseline and differential.
DR Genevisible; Q9T095; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISS:TAIR.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR PANTHER; PTHR22601; PTHR22601; 1.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00727; ISP4_OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Membrane; Peptide transport; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..736
FT /note="Oligopeptide transporter 6"
FT /id="PRO_0000213783"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 678..698
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 736 AA; 82361 MW; 0FE46ADA8AE99ECC CRC64;
MGEIATEFTP VMDDDDDRCV VPEVELTVPK TDDSTLPVLT FRMWVLGIGA CIVLSFINQF
FWYRTMPLSI TGISAQIAVV PLGHLMARVL PTKRFLEGTR FQFTLNPGAF NVKEHVLITI
FANSGAGSVY ATHILSAIKL YYKRSLPFLP AFLVMITTQI LGFGWAGLFR KHLVEPGEMW
WPSNLVQVSL FGALHEKEKK SRGGMSRTQF FLIVLVASFA YYIFPGYLFT MLTSISWVCW
LNPKSILVNQ LGSGEHGLGI GSIGFDWVTI SAYLGSPLAS PLFASVNVAI GFVLVMYIVT
PVCYWLNIYD AKTFPIFSSQ LFMGNGSRYD VLSIIDSKFH LDRVVYSRTG SINMSTFFAV
TYGLGFATLS ATIVHVLVFN GSDLWKQTRG AFQKNKKMDI HTRIMKKNYR EVPLWWFLVI
LLLNIALIMF ISVHYNATVQ LPWWGVLLAC AIAISFTPLI GVIAATTNQA PGLNIITEYV
IGYIYPERPV ANMCFKVYGY ISMTQALTFI SDFKLGHYMK IPPRSMFMAQ VAGTLVAVVV
YTGTAWWLME EIPHLCDTSL LPSDSQWTCP MDRVFFDASV IWGLVGPRRV FGDLGEYSNV
NWFFLVGAIA PLLVWLATKM FPAQTWIAKI HIPVLVGATA MMPPATAVNF TSWLIVAFIF
GHFIFKYRRV WWTKYNYVLS GGLDAGSAFM TILLFLALGR KGIEVQWWGN SGDRDTCPLA
SCPTAKGVVV KGCPVF
