OPT7_ARATH
ID OPT7_ARATH Reviewed; 766 AA.
AC O82485;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Oligopeptide transporter 7;
DE Short=AtOPT7;
GN Name=OPT7; OrderedLocusNames=At4g10770; ORFNames=T12H20.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=11788749; DOI=10.1104/pp.010332;
RA Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.;
RT "An oligopeptide transporter gene family in Arabidopsis.";
RL Plant Physiol. 128:21-29(2002).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15247401; DOI=10.1104/pp.104.039859;
RA Cagnac O., Bourbouloux A., Chakrabarty D., Zhang M.Y., Delrot S.;
RT "AtOPT6 transports glutathione derivatives and is induced by
RT primisulfuron.";
RL Plant Physiol. 135:1378-1387(2004).
CC -!- FUNCTION: Involved in the translocation of tetra- and pentapeptides
CC across the cellular membrane in an energy-dependent manner. May also
CC transport cadmium complexes. {ECO:0000269|PubMed:11788749,
CC ECO:0000269|PubMed:15247401}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the major and the first-order veins
CC and in the hydathodes of the leaves. In the roots, expressed in
CC circular zones surrounding lateral root primordia and in some part of
CC the root epidermis. Expressed also in the sepals and the cortical
CC tissues of the stem, but not in the conducting bundles, the petals or
CC the reproductive tissues. {ECO:0000269|PubMed:11788749,
CC ECO:0000269|PubMed:15247401}.
CC -!- DEVELOPMENTAL STAGE: Not expressed at the embryo stage.
CC {ECO:0000269|PubMed:15247401}.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter (TC 2.A.67.1)
CC family. {ECO:0000305}.
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DR EMBL; AF080119; AAC35527.1; -; Genomic_DNA.
DR EMBL; AL161518; CAB81178.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82927.1; -; Genomic_DNA.
DR EMBL; AY045668; AAK74026.1; -; mRNA.
DR EMBL; BT004519; AAO42765.1; -; mRNA.
DR PIR; T01900; T01900.
DR RefSeq; NP_192815.1; NM_117145.3.
DR AlphaFoldDB; O82485; -.
DR STRING; 3702.AT4G10770.1; -.
DR PaxDb; O82485; -.
DR PRIDE; O82485; -.
DR ProteomicsDB; 248821; -.
DR EnsemblPlants; AT4G10770.1; AT4G10770.1; AT4G10770.
DR GeneID; 826672; -.
DR Gramene; AT4G10770.1; AT4G10770.1; AT4G10770.
DR KEGG; ath:AT4G10770; -.
DR Araport; AT4G10770; -.
DR TAIR; locus:2132736; AT4G10770.
DR eggNOG; KOG2262; Eukaryota.
DR HOGENOM; CLU_004965_1_1_1; -.
DR InParanoid; O82485; -.
DR OMA; RWIVYPA; -.
DR OrthoDB; 190227at2759; -.
DR PhylomeDB; O82485; -.
DR PRO; PR:O82485; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O82485; baseline and differential.
DR Genevisible; O82485; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISS:TAIR.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR PANTHER; PTHR22601; PTHR22601; 2.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00727; ISP4_OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Membrane; Peptide transport; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..766
FT /note="Oligopeptide transporter 7"
FT /id="PRO_0000213784"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 709..729
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86136 MW; EAAE69CEB429B1FA CRC64;
MEESEQVLPL LTNPKDLTNP SYASSSSSSS EPRDETEDLL LPISDENEEE EEENSPIRQV
ALTVPTTDDP SLPVLTFRMW VLGTLSCILL SFLNQFFWYR TEPLTISAIS AQIAVVPLGR
LMAAKITDRV FFQGSKWQFT LNPGPFNVKE HVLITIFANA GAGSVYAIHV VTVVKAFYMK
NITFFVSFIV IVTTQVLGFG WAGIFRKYLV EPAAMWWPAN LVQVSLFRAL HEKEERTKGG
LTRTQFFVIA FVCSFAYYVF PGYLFQIMTS LSWVCWFFPS SVMAQQIGSG LHGLGVGAIG
LDWSTISSYL GSPLASPWFA TANVGVGFVL VIYVLVPICY WLDVYKAKTF PIFSSSLFSS
QGSKYNITSI IDSNFHLDLP AYERQGPLYL CTFFAISYGV GFAALSATIM HVALFHGREI
WEQSKESFKE KKLDVHARLM QRYKQVPEWW FWCILVTNVG ATIFACEYYN DQLQLPWWGV
LLACTVAIIF TLPIGIITAI TNQAPGLNII TEYIIGYIYP GYPVANMCFK VYGYISMQQA
ITFLQDFKLG HYMKIPPRTM FMAQIVGTLI SCFVYLTTAW WLMETIPNIC DSVTNSVWTC
PSDKVFYDAS VIWGLIGPRR IFGDLGLYKS VNWFFLVGAI APILVWLASR MFPRQEWIKL
INMPVLISAT SSMPPATAVN YTTWVLAGFL SGFVVFRYRP NLWQRYNYVL SGALDAGLAF
MGVLLYMCLG LENVSLDWWG NELDGCPLAS CPTAPGIIVE GCPLYT
