OPT8_ARATH
ID OPT8_ARATH Reviewed; 733 AA.
AC Q9FJD1; Q1PDJ8;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Oligopeptide transporter 8;
DE Short=AtOPT8;
GN Name=OPT8; OrderedLocusNames=At5g53520; ORFNames=MNC6.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP FUNCTION, AND NOMENCLATURE.
RX PubMed=11788749; DOI=10.1104/pp.010332;
RA Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.;
RT "An oligopeptide transporter gene family in Arabidopsis.";
RL Plant Physiol. 128:21-29(2002).
CC -!- FUNCTION: May be involved in the translocation of tetra- and
CC pentapeptides across the cellular membrane in an energy-dependent
CC manner. {ECO:0000250, ECO:0000269|PubMed:11788749}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter (TC 2.A.67.1)
CC family. {ECO:0000305}.
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DR EMBL; AB015476; BAB09728.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96372.1; -; Genomic_DNA.
DR EMBL; DQ447070; ABE66245.1; -; mRNA.
DR RefSeq; NP_200164.1; NM_124732.2.
DR AlphaFoldDB; Q9FJD1; -.
DR STRING; 3702.AT5G53520.1; -.
DR PaxDb; Q9FJD1; -.
DR PRIDE; Q9FJD1; -.
DR EnsemblPlants; AT5G53520.1; AT5G53520.1; AT5G53520.
DR GeneID; 835434; -.
DR Gramene; AT5G53520.1; AT5G53520.1; AT5G53520.
DR KEGG; ath:AT5G53520; -.
DR Araport; AT5G53520; -.
DR TAIR; locus:2168626; AT5G53520.
DR eggNOG; KOG2262; Eukaryota.
DR HOGENOM; CLU_004965_0_1_1; -.
DR InParanoid; Q9FJD1; -.
DR OMA; THFNTSM; -.
DR OrthoDB; 190227at2759; -.
DR PhylomeDB; Q9FJD1; -.
DR PRO; PR:Q9FJD1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJD1; baseline and differential.
DR Genevisible; Q9FJD1; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISS:TAIR.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0048235; P:pollen sperm cell differentiation; IEP:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR PANTHER; PTHR22601; PTHR22601; 1.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00727; ISP4_OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Membrane; Peptide transport; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..733
FT /note="Oligopeptide transporter 8"
FT /id="PRO_0000213785"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 733 AA; 82079 MW; B12CC2DA03E7043C CRC64;
MKDFTDTISE SECDDEISIV PQVELTVPKT DDPTSPTVTF RMWVLGITAC VLLSFLNQFF
WYRTNPLTIS SVSAQIAVVP IGHLMAKVLP TRRFFEGTRW SFTMNPGPFS TKEHVLITVF
ANSGSGAVYA THILSAVKLY YKRRLDFLPA LLVMITTQVL GFGWAGLYRK HLVEPGEMWW
PSNLVQVSLF RALHEKENKS KWGISRNQFF VITLITSFSY YLLPGYLFTV LTTVSWLCWI
SPKSILVNQL GSGSAGLGIG SFGLDWSTIA SYLGSPLASP FFASANIAAG FFLVMYVITP
LCYYLDLYNA KTFPIYSGKL FVASGKEYKV TSIIDANFRL DRQAYAETGP VHMSTFFAVT
YGLGFATLSA SIFHVLIFNG KDLWTQTRGA FGKNKKMDIH TKIMKRNYKE VPLWWFLSIF
AVNLAVIVFI CIYYKTQIQL PWWGAFLACL IAIFFTPLVG VIMATTNQAP GLNIITEYII
GYAYPERPVA NICFKTYGYI SMSQSLTFLS DLKLGTYMKI PPRTMFMAQV VGTLVAVIAY
AGTAWWLMAE IPNLCDTNLL PPGSQWTCPS DRVFFDASVI WGLVGPRRMF GDLGEYSNIN
WFFVGGAIAP ALVYLASRLF PNKKWISDIH IPVLIGATAI MPPASAVNFT SWLVMAFVFG
HFVFKYRREW WQRYNYVLSG GMDAGTGFMS VLLFLALQRS EIAIDWWGNS GEGCPVAKCP
TAKGVVVHGC PVF
