ID   ASA1_KLULA              Reviewed;         399 AA.
AC   Q6CRH2;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=ASA1; OrderedLocusNames=KLLA0D09086g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00563.1; -; Genomic_DNA.
DR   RefSeq; XP_453467.1; XM_453467.1.
DR   AlphaFoldDB; Q6CRH2; -.
DR   STRING; 28985.XP_453467.1; -.
DR   PRIDE; Q6CRH2; -.
DR   EnsemblFungi; CAH00563; CAH00563; KLLA0_D09086g.
DR   GeneID; 2892955; -.
DR   KEGG; kla:KLLA0_D09086g; -.
DR   eggNOG; ENOG502QU4T; Eukaryota.
DR   HOGENOM; CLU_045414_1_0_1; -.
DR   InParanoid; Q6CRH2; -.
DR   OMA; LVCCNTQ; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..399
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402211"
FT   REPEAT          7..49
FT                   /note="WD 1"
FT   REPEAT          51..88
FT                   /note="WD 2"
FT   REPEAT          101..141
FT                   /note="WD 3"
FT   REPEAT          269..314
FT                   /note="WD 4"
SQ   SEQUENCE   399 AA;  44829 MW;  B125064A977DDFEF CRC64;
     MPFTLRYHTC GVTSLLHWND EQDVPTLISG DEKGSILVWN LLSRKPYYKY TCRGQIVSFQ
     QLNDLIIATS KDHTLRILKF PSTLTTKEGF PDYSLPELEL IYEIPVNTLN FANTAVEQVD
     TNNYRLWCCN TQDSETIDIY EFDLRDSKSL KRIHRALSLY EVISGLVDPS TMKFDKLGTT
     MKFIIYEGII YLGFESGFVI GLRLTQGLHI VYISSANYPE PVLDLTVGKD LGKVISSSTN
     SSLGLHTPNI NTESHNNVSS KDVVVDDSTI HSEMVNIPIN KVSHIQQVDN LLIAASWSGR
     TVVFDINGNK VLASILKERG QVLIDDNPYG NASLPENSTK VKISAMTCIP KFNTVNPSCT
     SEGTRRRWIR FYKETWCLIG YADGSIKATE VTFDNLITA