OPUCB_LISMN
ID OPUCB_LISMN Reviewed; 218 AA.
AC Q9KHT8;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Carnitine transport permease protein OpuCB;
GN Name=opuCB;
OS Listeria monocytogenes.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1639;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBUNIT.
RC STRAIN=EGD / Serotype 1/2a;
RX PubMed=11055912; DOI=10.1128/aem.66.11.4696-4704.2000;
RA Fraser K.R., Harvie D., Coote P.J., O'Byrne C.P.;
RT "Identification and characterization of an ATP binding cassette L-carnitine
RT transporter in Listeria monocytogenes.";
RL Appl. Environ. Microbiol. 66:4696-4704(2000).
CC -!- FUNCTION: Part of the ABC transporter complex OpuCABCD involved in
CC carnitine uptake. Probably responsible for the translocation of the
CC substrate across the membrane. Involved, with BetL and GbuABC, in
CC osmoprotection and cryoprotection of Listeria.
CC {ECO:0000269|PubMed:11055912}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (OpuCA),
CC two transmembrane proteins (OpuCB and OpuCD) and a solute-binding
CC protein (OpuCC). {ECO:0000305|PubMed:11055912}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AF249729; AAF91340.1; -; Genomic_DNA.
DR PIR; AC1253; AC1253.
DR RefSeq; WP_003721932.1; NZ_WUEB01000003.1.
DR AlphaFoldDB; Q9KHT8; -.
DR SMR; Q9KHT8; -.
DR STRING; 1027396.LMOSA_23480; -.
DR eggNOG; COG1174; Bacteria.
DR OMA; MRYLFTH; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Stress response; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..218
FT /note="Carnitine transport permease protein OpuCB"
FT /id="PRO_0000418134"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 19..198
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 218 AA; 23337 MW; 2BF907BD581C67B2 CRC64;
MDAIVTFFQE NGHNLLVQTW QHLFISLSAV ILGIAVAVPT GILLTRSPKV ANFVIGVVSV
LQTVPSLAIL AFIIPFLGVG TLPAIIALFI YALLPILRNT FIGVRGVDKN LIESGRGMGM
TNWQLIVNVE IPNSISVIMA GIRLSAVYVI AWATLASYIG AGGLGDFIFN GLNLYRPDLI
LGGAIPVTIL ALVVEFALGK LEYRLTPKAI REAREGGE