ID   ASA1_LACTC              Reviewed;         416 AA.
AC   C5DLA7;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=ASA1; OrderedLocusNames=KLTH0F11440g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR24258.1; -; Genomic_DNA.
DR   RefSeq; XP_002554695.1; XM_002554649.1.
DR   AlphaFoldDB; C5DLA7; -.
DR   STRING; 559295.C5DLA7; -.
DR   PRIDE; C5DLA7; -.
DR   EnsemblFungi; CAR24258; CAR24258; KLTH0F11440g.
DR   GeneID; 8292908; -.
DR   KEGG; lth:KLTH0F11440g; -.
DR   eggNOG; ENOG502QU4T; Eukaryota.
DR   HOGENOM; CLU_045414_1_0_1; -.
DR   InParanoid; C5DLA7; -.
DR   OMA; LVCCNTQ; -.
DR   OrthoDB; 1543596at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..416
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402212"
FT   REPEAT          13..54
FT                   /note="WD 1"
FT   REPEAT          58..95
FT                   /note="WD 2"
FT   REPEAT          111..147
FT                   /note="WD 3"
FT   REPEAT          234..273
FT                   /note="WD 4"
SQ   SEQUENCE   416 AA;  47017 MW;  643317DD75ABE2CB CRC64;
     MQGHQPAAYT LRKHETEVTC LKVVSWEPYP VLASGDAKGE LYLWNLVTRR PFAGYKLETK
     AQIIYIKWLN NYLIVLSKDH TLRFLQLHNE TAVAIRGWAG NQFELQSFKI VYEVPVNTLN
     FANVVVTHMR ESQYRLWCCN TMDSESIDVY EFDVKEQRSL RRLVSGINLY KAIIKAGNWS
     TGESLDKTGI VMCFLEHNGV VYLGYECGFV LGLQLVERSG ENPTIVVSYV SSVHYPEPVL
     SLCYNEREEV ILSSSTNDAI GVHALQAHSV NVSESEIAFF SIEEGIAIKR DLTLINKSIH
     LPTSKIGHLG CVDGRLIAVD WSGRTLVCEK DETKFCFSKQ RSNVLVDESS AGTFDQGKAP
     RCHIKATSMA CIGKQTLREL RGIRRGEKRR TELCANRSWC FTGYEDGSVI MQSFET