OPY1_YEAST
ID OPY1_YEAST Reviewed; 328 AA.
AC P38271; D6VQC6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Protein OPY1;
DE AltName: Full=Overproduction-induced pheromone-resistant yeast protein 1;
GN Name=OPY1; OrderedLocusNames=YBR129C; ORFNames=YBR1004;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9383053; DOI=10.1093/genetics/147.3.1063;
RA Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr.,
RA Tyers M., Elledge S.J.;
RT "Human CPR (cell cycle progression restoration) genes impart a Far-
RT phenotype on yeast cells.";
RL Genetics 147:1063-1076(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091856; DOI=10.1002/yea.320100002;
RA Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F.,
RA Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M.,
RA Herbert C.J.;
RT "The sequence of 29.7 kb from the right arm of chromosome II reveals 13
RT complete open reading frames, of which ten correspond to new genes.";
RL Yeast 10:S1-S11(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; AF016262; AAB81505.1; -; mRNA.
DR EMBL; X75891; CAA53488.1; -; Genomic_DNA.
DR EMBL; Z35998; CAA85086.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07246.1; -; Genomic_DNA.
DR PIR; S45998; S45998.
DR RefSeq; NP_009687.1; NM_001178477.1.
DR AlphaFoldDB; P38271; -.
DR SMR; P38271; -.
DR BioGRID; 32830; 99.
DR DIP; DIP-4768N; -.
DR IntAct; P38271; 1.
DR STRING; 4932.YBR129C; -.
DR iPTMnet; P38271; -.
DR MaxQB; P38271; -.
DR PaxDb; P38271; -.
DR PRIDE; P38271; -.
DR EnsemblFungi; YBR129C_mRNA; YBR129C; YBR129C.
DR GeneID; 852426; -.
DR KEGG; sce:YBR129C; -.
DR SGD; S000000333; OPY1.
DR VEuPathDB; FungiDB:YBR129C; -.
DR eggNOG; ENOG502S04D; Eukaryota.
DR HOGENOM; CLU_038624_0_0_1; -.
DR InParanoid; P38271; -.
DR OMA; GQFSYYK; -.
DR BioCyc; YEAST:G3O-29084-MON; -.
DR PRO; PR:P38271; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38271; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:SGD.
DR GO; GO:1902647; P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; IMP:SGD.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR016609; Opy1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF00169; PH; 1.
DR PIRSF; PIRSF013217; UCP013217_Opy1; 1.
DR SMART; SM00233; PH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..328
FT /note="Protein OPY1"
FT /id="PRO_0000058074"
FT DOMAIN 215..318
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 19..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 37740 MW; BB4BECCA7C67A5D9 CRC64;
MIAGATAPSS QHEILIASNL IKKPSTSQNK TPTAQSSSGN NGAADGAPQG YHHHHHHHRH
LWWPRTTDHQ YWCVLRKNQF AYYKTRDERE AISVIPRFDI LNFKISELDG ILTVYTPSKD
LIFKFPRGQN EKVGMELMHN WKIALEKFLS SPSGNESVTT GSDYDEEEDD DDLIVVDEKA
GPSSSKHSCS LTMDEQLSRE DKEFYRMFDP RNAEHQVCSG ILYTKVKKKK LFNRAKWQKF
NVELTNTSFN LYSFKTGKLK KSIKLDKIID CIELDNNSKM KNDDTNFALI TFDERLSFKA
ANDQDMVDWI INFKSGILIR KKLKAENI
