ID   ASA1_LODEL              Reviewed;         400 AA.
AC   A5E5U8;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=ASA1; ORFNames=LELG_04987;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR   EMBL; CH981530; EDK46806.1; -; Genomic_DNA.
DR   RefSeq; XP_001524174.1; XM_001524124.1.
DR   AlphaFoldDB; A5E5U8; -.
DR   STRING; 379508.A5E5U8; -.
DR   EnsemblFungi; EDK46806; EDK46806; LELG_04987.
DR   GeneID; 5231130; -.
DR   KEGG; lel:LELG_04987; -.
DR   VEuPathDB; FungiDB:LELG_04987; -.
DR   eggNOG; ENOG502QU4T; Eukaryota.
DR   HOGENOM; CLU_045414_0_0_1; -.
DR   InParanoid; A5E5U8; -.
DR   OMA; LVCCNTQ; -.
DR   OrthoDB; 1543596at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..400
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402213"
FT   REPEAT          6..54
FT                   /note="WD 1"
FT   REPEAT          57..94
FT                   /note="WD 2"
FT   REPEAT          240..272
FT                   /note="WD 3"
FT   REPEAT          273..312
FT                   /note="WD 4"
SQ   SEQUENCE   400 AA;  45070 MW;  E171D2C033EF9CFA CRC64;
     MSSISSAPQQ QFSLRYHKAS ISYILPISSR YIYSADQSGL VIKWDLQIRR PKLQWQAHKD
     SILTILQWHQ YIVTHSRDST IKVWLEDILQ FEMPVNALNY TNIVLYRDNY LITPATLDSN
     NVDVYKLKQH PIEVSRVIAN ISIFELVNKT RTNMHANKAG DGVDINVKYA DEFAIDDKDN
     MQGRQDFGII MKMLVIDMTI YIGFESGDIV GLHLEVPESK LTRGSNSTLL INREPRLKLE
     YQNTLLVPNP VISLANLNGL LVSGSTGTKV VIHSDPTRTV KFHLSGIHSI QTYQDRLVIG
     FWDGAIEYKG EIIQRPLPQI KGGLDINSNG DDENEEENLK SNVKLTSMTL SSFGNSSGSD
     TAKVQHVRKP KYSEMVKAKS MSDALFAGYE DGTIMGYALI