OR1A1_HUMAN
ID OR1A1_HUMAN Reviewed; 309 AA.
AC Q9P1Q5; A5D914; Q6IFM1; Q6NTA9; Q96R87;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Olfactory receptor 1A1;
DE AltName: Full=Olfactory receptor 17-7;
DE Short=OR17-7;
DE AltName: Full=Olfactory receptor OR17-11;
GN Name=OR1A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-128.
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-285.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-281, AND VARIANT HIS-128.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1A1";
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DR EMBL; AF087918; AAF37311.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90520.1; -; Genomic_DNA.
DR EMBL; BC069169; AAH69169.1; -; mRNA.
DR EMBL; BC128248; AAI28249.1; -; mRNA.
DR EMBL; BC141934; AAI41935.1; -; mRNA.
DR EMBL; BC141935; AAI41936.1; -; mRNA.
DR EMBL; AF399555; AAK95040.1; -; Genomic_DNA.
DR EMBL; BK004241; DAA04639.1; -; Genomic_DNA.
DR CCDS; CCDS11022.1; -.
DR RefSeq; NP_055380.2; NM_014565.2.
DR AlphaFoldDB; Q9P1Q5; -.
DR SMR; Q9P1Q5; -.
DR BioGRID; 113973; 7.
DR STRING; 9606.ENSP00000305207; -.
DR GlyGen; Q9P1Q5; 2 sites.
DR iPTMnet; Q9P1Q5; -.
DR PhosphoSitePlus; Q9P1Q5; -.
DR BioMuta; OR1A1; -.
DR DMDM; 212276451; -.
DR MassIVE; Q9P1Q5; -.
DR PaxDb; Q9P1Q5; -.
DR PeptideAtlas; Q9P1Q5; -.
DR PRIDE; Q9P1Q5; -.
DR Antibodypedia; 52929; 52 antibodies from 16 providers.
DR DNASU; 8383; -.
DR Ensembl; ENST00000641322.1; ENSP00000492897.1; ENSG00000172146.4.
DR Ensembl; ENST00000641732.2; ENSP00000493179.1; ENSG00000172146.4.
DR GeneID; 8383; -.
DR KEGG; hsa:8383; -.
DR MANE-Select; ENST00000641732.2; ENSP00000493179.1; NM_014565.3; NP_055380.2.
DR UCSC; uc010vrc.2; human.
DR CTD; 8383; -.
DR GeneCards; OR1A1; -.
DR HGNC; HGNC:8179; OR1A1.
DR HPA; ENSG00000172146; Tissue enriched (brain).
DR MIM; 618046; gene.
DR neXtProt; NX_Q9P1Q5; -.
DR PharmGKB; PA32051; -.
DR VEuPathDB; HostDB:ENSG00000172146; -.
DR eggNOG; ENOG502TF5D; Eukaryota.
DR GeneTree; ENSGT00900000141057; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q9P1Q5; -.
DR OMA; QEDFFFT; -.
DR OrthoDB; 879962at2759; -.
DR PhylomeDB; Q9P1Q5; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q9P1Q5; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8383; 6 hits in 668 CRISPR screens.
DR GeneWiki; OR1A1; -.
DR GenomeRNAi; 8383; -.
DR Pharos; Q9P1Q5; Tdark.
DR PRO; PR:Q9P1Q5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9P1Q5; protein.
DR Bgee; ENSG00000172146; Expressed in gonad and 2 other tissues.
DR ExpressionAtlas; Q9P1Q5; baseline and differential.
DR Genevisible; Q9P1Q5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 1A1"
FT /id="PRO_0000150412"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 128
FT /note="R -> H (in dbSNP:rs4375699)"
FT /evidence="ECO:0000269|PubMed:10673334,
FT ECO:0000269|PubMed:12213199"
FT /id="VAR_047080"
FT VARIANT 233
FT /note="V -> M (in dbSNP:rs17762735)"
FT /id="VAR_034161"
FT VARIANT 285
FT /note="P -> S (in dbSNP:rs769427)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_020380"
SQ SEQUENCE 309 AA; 34565 MW; EE3D7E194C4CDD4D CRC64;
MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY
FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ MYFMIALGNT DSYILAAMAY
DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD
ITPLLKLSCS DIHFHVKMMY LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC
GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR
KLFNKRISS
