OR1A2_HUMAN
ID OR1A2_HUMAN Reviewed; 309 AA.
AC Q9Y585; Q3KPH3; Q6IFM0; Q6NTD8; Q96R86;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Olfactory receptor 1A2;
DE AltName: Full=Olfactory receptor 17-6;
DE Short=OR17-6;
DE AltName: Full=Olfactory receptor OR17-10;
GN Name=OR1A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-256; CYS-260 AND
RP CYS-293.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1A2";
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DR EMBL; AF155225; AAD39545.1; -; Genomic_DNA.
DR EMBL; BC069092; AAH69092.1; -; mRNA.
DR EMBL; BC106733; AAI06734.1; -; mRNA.
DR EMBL; BC106734; AAI06735.1; -; mRNA.
DR EMBL; AF399556; AAK95041.1; -; Genomic_DNA.
DR EMBL; BK004242; DAA04640.1; -; Genomic_DNA.
DR CCDS; CCDS11021.1; -.
DR RefSeq; NP_036484.1; NM_012352.2.
DR AlphaFoldDB; Q9Y585; -.
DR SMR; Q9Y585; -.
DR BioGRID; 117602; 11.
DR STRING; 9606.ENSP00000371377; -.
DR GlyGen; Q9Y585; 1 site.
DR iPTMnet; Q9Y585; -.
DR PhosphoSitePlus; Q9Y585; -.
DR BioMuta; OR1A2; -.
DR DMDM; 9297027; -.
DR MassIVE; Q9Y585; -.
DR PaxDb; Q9Y585; -.
DR PeptideAtlas; Q9Y585; -.
DR PRIDE; Q9Y585; -.
DR Antibodypedia; 62121; 32 antibodies from 16 providers.
DR DNASU; 26189; -.
DR Ensembl; ENST00000381951.1; ENSP00000371377.1; ENSG00000172150.4.
DR GeneID; 26189; -.
DR KEGG; hsa:26189; -.
DR MANE-Select; ENST00000381951.1; ENSP00000371377.1; NM_012352.3; NP_036484.1.
DR UCSC; uc002fvd.1; human.
DR CTD; 26189; -.
DR GeneCards; OR1A2; -.
DR HGNC; HGNC:8180; OR1A2.
DR HPA; ENSG00000172150; Not detected.
DR MIM; 618047; gene.
DR neXtProt; NX_Q9Y585; -.
DR OpenTargets; ENSG00000172150; -.
DR PharmGKB; PA32052; -.
DR VEuPathDB; HostDB:ENSG00000172150; -.
DR eggNOG; ENOG502TF5D; Eukaryota.
DR GeneTree; ENSGT00900000141057; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q9Y585; -.
DR OMA; GTTMGMY; -.
DR OrthoDB; 879962at2759; -.
DR PhylomeDB; Q9Y585; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q9Y585; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26189; 3 hits in 665 CRISPR screens.
DR GeneWiki; OR1A2; -.
DR GenomeRNAi; 26189; -.
DR Pharos; Q9Y585; Tdark.
DR PRO; PR:Q9Y585; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9Y585; protein.
DR ExpressionAtlas; Q9Y585; differential.
DR Genevisible; Q9Y585; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 1A2"
FT /id="PRO_0000150415"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 244
FT /note="L -> F (in dbSNP:rs56058341)"
FT /id="VAR_062007"
FT VARIANT 256
FT /note="G -> C (in dbSNP:rs2241091)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_022047"
FT VARIANT 260
FT /note="R -> C (in dbSNP:rs2469791)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034162"
FT VARIANT 293
FT /note="W -> C (in dbSNP:rs12150427)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034163"
SQ SEQUENCE 309 AA; 34396 MW; 0BB9B26EB8D51B90 CRC64;
MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY
FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ MYFMIALAKA DSYTLAAMAY
DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD
IMPLLKLSCS DVHFNVKMMY LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC
GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ
KLFSKRISS
