OR1B1_HUMAN
ID OR1B1_HUMAN Reviewed; 318 AA.
AC Q8NGR6; Q6IFN3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 1B1;
DE AltName: Full=Olfactory receptor 9-B;
DE Short=OR9-B;
DE AltName: Full=Olfactory receptor OR9-26;
GN Name=OR1B1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Arg-192 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene. The stop codon is more frequent in non-Africans than in
CC African-Americans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04627.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1B1";
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DR EMBL; AB065723; BAC05944.1; -; Genomic_DNA.
DR EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004229; DAA04627.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001004450.1; NM_001004450.1.
DR RefSeq; XP_016870184.1; XM_017014695.1.
DR RefSeq; XP_016870185.1; XM_017014696.1.
DR AlphaFoldDB; Q8NGR6; -.
DR SMR; Q8NGR6; -.
DR STRING; 9606.ENSP00000303151; -.
DR GlyGen; Q8NGR6; 2 sites.
DR PhosphoSitePlus; Q8NGR6; -.
DR BioMuta; OR1B1; -.
DR DMDM; 166214963; -.
DR jPOST; Q8NGR6; -.
DR MassIVE; Q8NGR6; -.
DR PaxDb; Q8NGR6; -.
DR PeptideAtlas; Q8NGR6; -.
DR PRIDE; Q8NGR6; -.
DR Antibodypedia; 78801; 51 antibodies from 16 providers.
DR DNASU; 347169; -.
DR Ensembl; ENST00000623530.1; ENSP00000485577.1; ENSG00000280094.2.
DR GeneID; 347169; -.
DR KEGG; hsa:347169; -.
DR UCSC; uc011lyz.2; human.
DR CTD; 347169; -.
DR DisGeNET; 347169; -.
DR GeneCards; OR1B1; -.
DR HGNC; HGNC:8181; OR1B1.
DR HPA; ENSG00000280094; Not detected.
DR neXtProt; NX_Q8NGR6; -.
DR PharmGKB; PA32055; -.
DR VEuPathDB; HostDB:ENSG00000280094; -.
DR eggNOG; ENOG502QWKX; Eukaryota.
DR GeneTree; ENSGT00900000141254; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGR6; -.
DR OMA; VSVVHTM; -.
DR OrthoDB; 892347at2759; -.
DR PhylomeDB; Q8NGR6; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGR6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 347169; 9 hits in 664 CRISPR screens.
DR GeneWiki; OR1B1; -.
DR GenomeRNAi; 347169; -.
DR Pharos; Q8NGR6; Tdark.
DR PRO; PR:Q8NGR6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGR6; protein.
DR Bgee; ENSG00000280094; Expressed in cortical plate and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 1B1"
FT /id="PRO_0000150416"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 149
FT /note="L -> S (in dbSNP:rs1536929)"
FT /id="VAR_053114"
FT VARIANT 230
FT /note="A -> T (in dbSNP:rs1476859)"
FT /id="VAR_053115"
FT VARIANT 263
FT /note="C -> W (in dbSNP:rs1476858)"
FT /id="VAR_053116"
FT VARIANT 314
FT /note="V -> G (in dbSNP:rs1556189)"
FT /id="VAR_053117"
SQ SEQUENCE 318 AA; 35293 MW; 0CA0D7808259807B CRC64;
MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL ISWDSRLHSP
MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL AQFFFFYAFG VTDTLVIAVM
ALDRYVAICD PLHYALVMNH QRCACLLALS WVVSILHTML RVGLVLPLCW TGDAGGNVNL
PHFFCDHRPL LRASCSDIHS NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR
RRAVSTCGSH LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN
KDVKGALCRL LEWVKVDP
