OR1D4_HUMAN
ID OR1D4_HUMAN Reviewed; 311 AA.
AC P47884; Q96RA5; Q9UM75;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2003, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 1D4;
DE AltName: Full=Olfactory receptor 17-30;
DE Short=OR17-30;
GN Name=OR1D4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1D4";
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DR EMBL; AF087922; AAF37312.1; -; Genomic_DNA.
DR EMBL; U04681; AAA18345.1; -; Genomic_DNA.
DR EMBL; AF399534; AAK95019.1; -; Genomic_DNA.
DR PIR; I38473; I38473.
DR AlphaFoldDB; P47884; -.
DR SMR; P47884; -.
DR GlyGen; P47884; 1 site.
DR BioMuta; HGNC:8185; -.
DR DMDM; 37538298; -.
DR PRIDE; P47884; -.
DR GeneCards; OR1D4; -.
DR HGNC; HGNC:8185; OR1D4.
DR neXtProt; NX_P47884; -.
DR InParanoid; P47884; -.
DR PathwayCommons; P47884; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; P47884; Tdark.
DR PRO; PR:P47884; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P47884; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 1D4"
FT /id="PRO_0000150421"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 204
FT /note="C -> W (in Ref. 1; AAF37312)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 35227 MW; BACD6DA94E7B4B51 CRC64;
MDGDNQSENS QFLLLGISES PEQQQILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY
FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY
DRYVAICCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD
MYILLWLACS NTHIIHTALI ATGCFIFLTL LGFMTTSYVR IVRTILQMPS ASKKYKTFST
CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYS LRNKDMHGAP
GRVLWRPFQR P
