OR1D5_HUMAN
ID OR1D5_HUMAN Reviewed; 312 AA.
AC P58170; A0AUK4; Q96RA6;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 1D5;
DE AltName: Full=Olfactory receptor 17-31;
DE Short=OR17-31;
GN Name=OR1D5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ferraz C., Demaille J.G.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-197.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1D5";
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DR EMBL; AF087923; AAF37313.1; -; Genomic_DNA.
DR EMBL; U53930; AAD10841.1; -; Genomic_DNA.
DR EMBL; AF399533; AAK95018.1; -; Genomic_DNA.
DR EMBL; BC106876; AAI06877.1; -; mRNA.
DR CCDS; CCDS58499.1; -.
DR RefSeq; NP_055381.1; NM_014566.1.
DR AlphaFoldDB; P58170; -.
DR SMR; P58170; -.
DR BioGRID; 113976; 19.
DR IntAct; P58170; 1.
DR STRING; 9606.ENSP00000459028; -.
DR GlyGen; P58170; 1 site.
DR BioMuta; OR1D5; -.
DR DMDM; 14423784; -.
DR PaxDb; P58170; -.
DR PeptideAtlas; P58170; -.
DR PRIDE; P58170; -.
DR Antibodypedia; 62120; 79 antibodies from 20 providers.
DR DNASU; 8386; -.
DR Ensembl; ENST00000575751.1; ENSP00000459028.1; ENSG00000262628.1.
DR GeneID; 8386; -.
DR KEGG; hsa:8386; -.
DR MANE-Select; ENST00000575751.1; ENSP00000459028.1; NM_014566.1; NP_055381.1.
DR UCSC; uc021tns.1; human.
DR CTD; 8386; -.
DR GeneCards; OR1D5; -.
DR HGNC; HGNC:8186; OR1D5.
DR HPA; ENSG00000262628; Not detected.
DR neXtProt; NX_P58170; -.
DR PharmGKB; PA32060; -.
DR VEuPathDB; HostDB:ENSG00000262628; -.
DR eggNOG; ENOG502T9JB; Eukaryota.
DR GeneTree; ENSGT00940000164752; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; P58170; -.
DR OMA; ITTGCFI; -.
DR OrthoDB; 971471at2759; -.
DR PhylomeDB; P58170; -.
DR PathwayCommons; P58170; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8386; 12 hits in 620 CRISPR screens.
DR GeneWiki; OR1D5; -.
DR GenomeRNAi; 8386; -.
DR Pharos; P58170; Tdark.
DR PRO; PR:P58170; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P58170; protein.
DR Bgee; ENSG00000262628; Expressed in reproductive system and 4 other tissues.
DR ExpressionAtlas; P58170; baseline and differential.
DR Genevisible; P58170; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 1D5"
FT /id="PRO_0000150422"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35424 MW; 94D238A76AE37829 CRC64;
MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY
FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY
DRYVATCCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD
MYILLWLACS NTHIIHTALI ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST
CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP
GRVLWRPFQR PK
