ID   ASA1_NEUCR              Reviewed;         485 AA.
AC   A7UWE6;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=asa-1; ORFNames=NCU11283;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR   EMBL; CM002239; EDO65236.1; -; Genomic_DNA.
DR   RefSeq; XP_001728327.1; XM_001728275.2.
DR   AlphaFoldDB; A7UWE6; -.
DR   STRING; 5141.EFNCRP00000004082; -.
DR   EnsemblFungi; EDO65236; EDO65236; NCU11283.
DR   GeneID; 5847597; -.
DR   KEGG; ncr:NCU11283; -.
DR   VEuPathDB; FungiDB:NCU11283; -.
DR   HOGENOM; CLU_041940_0_1_1; -.
DR   InParanoid; A7UWE6; -.
DR   OMA; AWDLTIM; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..485
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402215"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT   REPEAT          58..96
FT                   /note="WD 2"
FT   REPEAT          238..277
FT                   /note="WD 3"
FT   REPEAT          346..385
FT                   /note="WD 4"
FT   REPEAT          451..485
FT                   /note="WD 5"
FT   REGION          273..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  52609 MW;  F622E01BEAE54F1C CRC64;
     MAVEGRPPTP KSILRGHKAQ VHAATFIRNN ERLVTGDADG FVIAWDLTIM RPRAVWQAHD
     NAILGIAGWG NDRIITHGRD NKLIVWKLIG DDEARMSTTL PLDPCAEPRP KPWILHLLEV
     NTMNFCSFSY CPVSAPVLPG QQEGQSQDTA QESRFESELL IAVPNTLASE AIDIFHLPSQ
     TRRHTVKLGD KNGMVMAVAL FNQADSLTLV AGYENGLAIV AHRDPVKNDW VPLYQATCHS
     QPILSLSVSP ARDFFLTSSA DAVIAKHPLP SVVSQDTTST HATTTQAAQV SESEESSSPV
     NTGDKAVGKS LLGAALAKEK QNPSSQPKRS LKPEEVLTHP LKTVNTKHAG QQSIEIRSDG
     LIFATAGWDS KIRVYSTKTL KEVAVLKWHQ VGCYAVAFAH IAPNTGAPSI NDQNPKATVS
     TTGTQPATSD SLGHGTQKPN MDQSLTVVPK LVELTVRDKR LRQAKAAHWL AAGSKDGKVS
     LWDVF