OR1E2_HUMAN
ID OR1E2_HUMAN Reviewed; 323 AA.
AC P47887; O43877; O95632; Q0VAD5; Q0VAD6; Q9UL13;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Olfactory receptor 1E2;
DE AltName: Full=Olfactory receptor 17-93/17-135/17-136;
DE Short=OR17-135;
DE Short=OR17-136;
DE Short=OR17-93;
DE AltName: Full=Olfactory receptor 1E4;
GN Name=OR1E2; Synonyms=OR1E4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ferraz C., Vidal S., Brun C., Demaille J.G.;
RT "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory
RT receptor gene cluster of human chromosome 17p13.3, containing OR genes 2,
RT 201, 93 and pseudogene 1.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-27.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-292.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-292.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-292.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-323.
RA Ferraz C., Demaille J.G.;
RT "Sequence of cosmid ICRF105cH07155 of the olfactory receptor gene cluster
RT of human chromosome 17p13.3.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] ASP-168.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1E2";
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DR EMBL; AF087925; AAF37315.1; -; Genomic_DNA.
DR EMBL; AF095725; AAF03260.1; -; Genomic_DNA.
DR EMBL; BC121105; AAI21106.1; -; mRNA.
DR EMBL; BC121106; AAI21107.1; -; mRNA.
DR EMBL; U04686; AAA18349.1; -; Genomic_DNA.
DR EMBL; U86241; AAC39621.1; -; Genomic_DNA.
DR EMBL; U86242; AAC39622.1; -; Genomic_DNA.
DR EMBL; AF399551; AAK95036.1; -; Genomic_DNA.
DR EMBL; U76377; AAD00249.1; -; Genomic_DNA.
DR CCDS; CCDS11026.1; -.
DR PIR; I38478; I38478.
DR RefSeq; NP_003545.1; NM_003554.2.
DR AlphaFoldDB; P47887; -.
DR SMR; P47887; -.
DR BioGRID; 113978; 1.
DR STRING; 9606.ENSP00000248384; -.
DR GlyGen; P47887; 2 sites.
DR iPTMnet; P47887; -.
DR PhosphoSitePlus; P47887; -.
DR BioMuta; OR1E2; -.
DR DMDM; 9297116; -.
DR PaxDb; P47887; -.
DR PRIDE; P47887; -.
DR ProteomicsDB; 55811; -.
DR Antibodypedia; 52932; 12 antibodies from 8 providers.
DR DNASU; 8388; -.
DR Ensembl; ENST00000248384.1; ENSP00000248384.1; ENSG00000127780.3.
DR GeneID; 8388; -.
DR KEGG; hsa:8388; -.
DR MANE-Select; ENST00000248384.1; ENSP00000248384.1; NM_003554.2; NP_003545.1.
DR UCSC; uc010vre.2; human.
DR CTD; 8388; -.
DR DisGeNET; 8388; -.
DR GeneCards; OR1E2; -.
DR HGNC; HGNC:8190; OR1E2.
DR HPA; ENSG00000127780; Tissue enriched (brain).
DR neXtProt; NX_P47887; -.
DR PharmGKB; PA32063; -.
DR VEuPathDB; HostDB:ENSG00000127780; -.
DR eggNOG; ENOG502SI5J; Eukaryota.
DR GeneTree; ENSGT00940000165283; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; P47887; -.
DR OMA; CEDNTIP; -.
DR OrthoDB; 924696at2759; -.
DR PhylomeDB; P47887; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; P47887; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8388; 239 hits in 619 CRISPR screens.
DR GeneWiki; OR1E2; -.
DR GenomeRNAi; 8388; -.
DR Pharos; P47887; Tdark.
DR PRO; PR:P47887; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P47887; protein.
DR Bgee; ENSG00000127780; Expressed in hindlimb stylopod muscle and 2 other tissues.
DR ExpressionAtlas; P47887; baseline and differential.
DR Genevisible; P47887; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 1E2"
FT /id="PRO_0000150428"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 27
FT /note="C -> R (in dbSNP:rs769431)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029292"
FT VARIANT 168
FT /note="H -> D (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036207"
FT CONFLICT 95
FT /note="A -> E (in Ref. 5; AAC39621)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="S -> T (in Ref. 5; AAC39621)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="P -> S (in Ref. 5; AAC39621)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 36391 MW; 19AADA692BD92D3F CRC64;
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPVY
LFLSNLSFSD LCFSSVTMPK LLQNMQNQDP SIPYADCLTQ MYFFLYFSDL ESFLLVAMAY
DRYVAICFPM HYTAICFLLH YTAIMSPMLC LSVVALSWVL TTFHAMLHTL LMARLCFCAD
NVIPHFFCDM SALLKLACSD TRVNEWVIFI MGGLILVIPF LLILGSYARI VSSILKVPSS
KGICKAFSTC GSHLSVVSLF YGTVIGLYLC PSANSSTLKD TVMAMMYTVV TPMLTPFIYS
LRNRDMKGAL ERVICKRKNP FLL
