OR1F2_HUMAN
ID OR1F2_HUMAN Reviewed; 312 AA.
AC Q96R84;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Putative olfactory receptor 1F2;
DE AltName: Full=OLFmf2;
GN Name=OR1F2P; Synonyms=OR1F2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9653642; DOI=10.1006/geno.1998.5313;
RA Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L.,
RA Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C.,
RA Caloustian C., Gyapay G., Delpech M., Weissenbach J.;
RT "A transcriptional map of the FMF region.";
RL Genomics 50:147-160(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AJ003145; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1F2";
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DR EMBL; AJ003145; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF399558; AAK95043.1; -; Genomic_DNA.
DR AlphaFoldDB; Q96R84; -.
DR SMR; Q96R84; -.
DR BioMuta; HGNC:8196; -.
DR PeptideAtlas; Q96R84; -.
DR PRIDE; Q96R84; -.
DR GeneCards; OR1F2P; -.
DR HGNC; HGNC:8196; OR1F2P.
DR neXtProt; NX_Q96R84; -.
DR PharmGKB; PA32075; -.
DR InParanoid; Q96R84; -.
DR PhylomeDB; Q96R84; -.
DR PathwayCommons; Q96R84; -.
DR Pharos; Q96R84; Tdark.
DR PRO; PR:Q96R84; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96R84; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Putative olfactory receptor 1F2"
FT /id="PRO_0000150432"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 136
FT /note="I -> T (in Ref. 2; AAK95043)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34944 MW; 96B49B6DDBB11285 CRC64;
MERDKPVSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILAIS IDSRLHTPMY
FFLSNMSFVD NCFSTTVPKM LANHILRTQT ISFSGCLMQM YFISELADMD NFLLAVMAYD
RFVAVCRPLH YTAKMIHQLC ALLVTGSWVV ANSNALLHTL LMARLSFCAD NTIPHIFCDV
TPLLKLSCSD THLSEVMILT EAALVTITPF LCLLASYMHI TCVVLRVPST KGRWKAFSTC
GSHLAVVLLF YGTIMSPYFR TSSSHSAQRD IAAAVRFTVV TPVMNPLIYS LRNKDIKGAL
VKVVAVKFFS VQ
