OR1G1_HUMAN
ID OR1G1_HUMAN Reviewed; 313 AA.
AC P47890; Q4VBM1; Q6IFL9; Q9UM76;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Olfactory receptor 1G1;
DE AltName: Full=Olfactory receptor 17-209;
DE Short=OR17-209;
DE AltName: Full=Olfactory receptor 1G2;
DE AltName: Full=Olfactory receptor OR17-8;
GN Name=OR1G1; Synonyms=OR1G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ferraz C., Demaille J.G.;
RT "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3
RT olfactory receptor gene cluster.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04641.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1G1";
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DR EMBL; AF087928; AAF37317.1; -; Genomic_DNA.
DR EMBL; U53583; AAC99556.1; -; Genomic_DNA.
DR EMBL; BC069379; AAH69379.1; -; mRNA.
DR EMBL; BC095520; AAH95520.1; -; mRNA.
DR EMBL; U04689; AAA18352.1; -; Genomic_DNA.
DR EMBL; BK004243; DAA04641.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS11020.1; -.
DR PIR; I38481; I38481.
DR RefSeq; NP_003546.1; NM_003555.1.
DR AlphaFoldDB; P47890; -.
DR SMR; P47890; -.
DR STRING; 9606.ENSP00000331545; -.
DR GlyGen; P47890; 1 site.
DR BioMuta; OR1G1; -.
DR DMDM; 9297118; -.
DR MassIVE; P47890; -.
DR PaxDb; P47890; -.
DR PeptideAtlas; P47890; -.
DR PRIDE; P47890; -.
DR Antibodypedia; 22997; 34 antibodies from 18 providers.
DR DNASU; 8390; -.
DR Ensembl; ENST00000328890.3; ENSP00000331545.2; ENSG00000183024.4.
DR GeneID; 8390; -.
DR KEGG; hsa:8390; -.
DR MANE-Select; ENST00000328890.3; ENSP00000331545.2; NM_003555.1; NP_003546.1.
DR UCSC; uc002fvc.2; human.
DR CTD; 8390; -.
DR DisGeNET; 8390; -.
DR GeneCards; OR1G1; -.
DR HGNC; HGNC:8204; OR1G1.
DR HPA; ENSG00000183024; Not detected.
DR neXtProt; NX_P47890; -.
DR OpenTargets; ENSG00000183024; -.
DR PharmGKB; PA32076; -.
DR VEuPathDB; HostDB:ENSG00000183024; -.
DR eggNOG; ENOG502TA75; Eukaryota.
DR GeneTree; ENSGT00940000164509; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; P47890; -.
DR OMA; PLHYIMV; -.
DR OrthoDB; 869668at2759; -.
DR PhylomeDB; P47890; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; P47890; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8390; 5 hits in 668 CRISPR screens.
DR ChiTaRS; OR1G1; human.
DR GeneWiki; OR1G1; -.
DR GenomeRNAi; 8390; -.
DR Pharos; P47890; Tdark.
DR PRO; PR:P47890; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P47890; protein.
DR Bgee; ENSG00000183024; Expressed in ventricular zone and 3 other tissues.
DR ExpressionAtlas; P47890; baseline and differential.
DR Genevisible; P47890; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 1G1"
FT /id="PRO_0000150434"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 88
FT /note="Q -> H (in dbSNP:rs9892491)"
FT /id="VAR_053122"
FT CONFLICT 95
FT /note="S -> L (in Ref. 4; AAA18352)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="A -> G (in Ref. 4; AAA18352)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 34924 MW; 556C28EB731FD003 CRC64;
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY
FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ LYFFMLFVML EAFLLAVMAY
DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD
INPLLSLSCT DPFTNELVIF ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST
CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS
LRKLIWVRKI HSP
