OR1I1_HUMAN
ID OR1I1_HUMAN Reviewed; 355 AA.
AC O60431; B2RU23; Q96R92;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Olfactory receptor 1I1;
DE AltName: Full=Olfactory receptor 19-20;
DE Short=OR19-20;
GN Name=OR1I1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-163 AND PHE-282.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1I1";
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DR EMBL; AC004794; AAC18915.1; -; Genomic_DNA.
DR EMBL; BC140930; AAI40931.1; -; mRNA.
DR EMBL; AF399548; AAK95033.1; -; Genomic_DNA.
DR CCDS; CCDS32937.1; -.
DR RefSeq; NP_001004713.1; NM_001004713.1.
DR AlphaFoldDB; O60431; -.
DR SMR; O60431; -.
DR STRING; 9606.ENSP00000209540; -.
DR iPTMnet; O60431; -.
DR PhosphoSitePlus; O60431; -.
DR BioMuta; OR1I1; -.
DR MassIVE; O60431; -.
DR PaxDb; O60431; -.
DR PeptideAtlas; O60431; -.
DR PRIDE; O60431; -.
DR ProteomicsDB; 49401; -.
DR Antibodypedia; 26948; 86 antibodies from 20 providers.
DR DNASU; 126370; -.
DR Ensembl; ENST00000209540.2; ENSP00000209540.2; ENSG00000094661.3.
DR Ensembl; ENST00000641398.1; ENSP00000493393.1; ENSG00000094661.3.
DR GeneID; 126370; -.
DR KEGG; hsa:126370; -.
DR MANE-Select; ENST00000641398.1; ENSP00000493393.1; NM_001004713.2; NP_001004713.1.
DR UCSC; uc010xoe.3; human.
DR CTD; 126370; -.
DR GeneCards; OR1I1; -.
DR HGNC; HGNC:8207; OR1I1.
DR HPA; ENSG00000094661; Tissue enhanced (brain).
DR neXtProt; NX_O60431; -.
DR PharmGKB; PA32078; -.
DR VEuPathDB; HostDB:ENSG00000094661; -.
DR eggNOG; ENOG502TM5B; Eukaryota.
DR GeneTree; ENSGT00940000162852; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; O60431; -.
DR OMA; CAGSEIP; -.
DR OrthoDB; 866647at2759; -.
DR PhylomeDB; O60431; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; O60431; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 126370; 8 hits in 668 CRISPR screens.
DR GeneWiki; OR1I1; -.
DR GenomeRNAi; 126370; -.
DR Pharos; O60431; Tdark.
DR PRO; PR:O60431; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O60431; protein.
DR Bgee; ENSG00000094661; Expressed in tibialis anterior and 12 other tissues.
DR Genevisible; O60431; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..355
FT /note="Olfactory receptor 1I1"
FT /id="PRO_0000150437"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 50
FT /note="I -> F (in dbSNP:rs59166286)"
FT /id="VAR_062009"
FT VARIANT 139
FT /note="P -> R (in dbSNP:rs8104843)"
FT /id="VAR_034164"
FT VARIANT 163
FT /note="M -> L (in dbSNP:rs76524797)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_080450"
FT VARIANT 211
FT /note="F -> L (in dbSNP:rs8108721)"
FT /id="VAR_034165"
FT VARIANT 252
FT /note="Y -> S (in dbSNP:rs8105737)"
FT /id="VAR_034166"
FT VARIANT 282
FT /note="I -> F (in dbSNP:rs75323205)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_080451"
FT VARIANT 292
FT /note="I -> T (in dbSNP:rs16980312)"
FT /id="VAR_034167"
SQ SEQUENCE 355 AA; 39297 MW; 0C210102C186E413 CRC64;
MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII TDSHLHTPMY
FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ MYAFHLFGTM DSFLLAVMAI
DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM ITNLQSLIHT CLMAQLTFCA GSEISHFFCD
LMPLLKLSGS DTHTNELVIF AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST
CGLHLTVVSL SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA
LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG NRDME
