OR1J1_HUMAN
ID OR1J1_HUMAN Reviewed; 322 AA.
AC Q8NGS3; A3KFL8; Q6IF10; Q96R88;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 1J1;
DE AltName: Full=Olfactory receptor OR9-18;
GN Name=OR1J1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-318.
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1J1";
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DR EMBL; AB065716; BAC05937.1; -; Genomic_DNA.
DR EMBL; AL353767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136933; AAI36934.1; -; mRNA.
DR EMBL; BC136938; AAI36939.1; -; mRNA.
DR EMBL; AF399554; AAK95039.1; -; Genomic_DNA.
DR EMBL; BK004452; DAA04850.1; -; Genomic_DNA.
DR CCDS; CCDS35120.1; -.
DR RefSeq; NP_001004451.1; NM_001004451.1.
DR AlphaFoldDB; Q8NGS3; -.
DR SMR; Q8NGS3; -.
DR STRING; 9606.ENSP00000259357; -.
DR GlyGen; Q8NGS3; 1 site.
DR iPTMnet; Q8NGS3; -.
DR PhosphoSitePlus; Q8NGS3; -.
DR BioMuta; OR1J1; -.
DR DMDM; 38372762; -.
DR MassIVE; Q8NGS3; -.
DR PaxDb; Q8NGS3; -.
DR PeptideAtlas; Q8NGS3; -.
DR PRIDE; Q8NGS3; -.
DR Antibodypedia; 30306; 50 antibodies from 18 providers.
DR DNASU; 347168; -.
DR Ensembl; ENST00000259357.3; ENSP00000259357.2; ENSG00000136834.3.
DR GeneID; 347168; -.
DR KEGG; hsa:347168; -.
DR MANE-Select; ENST00000259357.3; ENSP00000259357.2; NM_001004451.1; NP_001004451.1.
DR UCSC; uc011lyu.2; human.
DR CTD; 347168; -.
DR GeneCards; OR1J1; -.
DR HGNC; HGNC:8208; OR1J1.
DR HPA; ENSG00000136834; Not detected.
DR neXtProt; NX_Q8NGS3; -.
DR OpenTargets; ENSG00000136834; -.
DR PharmGKB; PA32079; -.
DR VEuPathDB; HostDB:ENSG00000136834; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000163027; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8NGS3; -.
DR OMA; WVIACAC; -.
DR OrthoDB; 1093328at2759; -.
DR PhylomeDB; Q8NGS3; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGS3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 347168; 243 hits in 666 CRISPR screens.
DR GeneWiki; OR1J1; -.
DR GenomeRNAi; 347168; -.
DR Pharos; Q8NGS3; Tdark.
DR PRO; PR:Q8NGS3; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGS3; protein.
DR Bgee; ENSG00000136834; Expressed in endometrium and 7 other tissues.
DR ExpressionAtlas; Q8NGS3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..322
FT /note="Olfactory receptor 1J1"
FT /id="PRO_0000150438"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 318
FT /note="N -> S (in dbSNP:rs1962091)"
FT /evidence="ECO:0000269|PubMed:15164053"
FT /id="VAR_059978"
SQ SEQUENCE 322 AA; 35493 MW; CC16D5230B280378 CRC64;
MSPENQSSVS EFLLLGLPIR PEQQAVFFAL FLGMYLTTVL GNLLIMLLIQ LDSHLHTPMY
FFLSHLALTD ISFSSVTVPK MLMNMQTQHL AVFYKGCISQ TYFFIFFADL DSFLITSMAY
DRYVAICHPL HYATIMTQSQ CVMLVAGSWV IACACALLHT LLLAQLSFCA DHIIPHYFCD
LGALLKLSCS DTSLNQLAIF TAALTAIMLP FLCILVSYGH IGVTILQIPS TKGICKALST
CGSHLSVVTI YYRTIIGLYF LPPSSNTNDK NIIASVIYTA VTPMLNPFIY SLRNKDIKGA
LRKLLSRSGA VAHACNLNTL GG
