OR1J2_HUMAN
ID OR1J2_HUMAN Reviewed; 313 AA.
AC Q8NGS2; A3KFL9; Q6IF14; Q96R90; Q9NZP1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 1J2;
DE AltName: Full=HSA5;
DE AltName: Full=HTPCRX15;
DE AltName: Full=OST044;
DE AltName: Full=Olfactory receptor 1J3;
DE AltName: Full=Olfactory receptor 1J5;
DE AltName: Full=Olfactory receptor OR9-19;
GN Name=OR1J2; Synonyms=OR1J3, OR1J5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-285.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1J2";
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DR EMBL; AB065717; BAC05938.1; -; Genomic_DNA.
DR EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87531.1; -; Genomic_DNA.
DR EMBL; AF399552; AAK95037.1; -; Genomic_DNA.
DR EMBL; AF179767; AAF40352.1; -; Genomic_DNA.
DR EMBL; X64989; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004448; DAA04846.1; -; Genomic_DNA.
DR CCDS; CCDS35121.1; -.
DR RefSeq; NP_473448.1; NM_054107.1.
DR RefSeq; XP_016870112.1; XM_017014623.1.
DR AlphaFoldDB; Q8NGS2; -.
DR SMR; Q8NGS2; -.
DR STRING; 9606.ENSP00000335575; -.
DR GlyGen; Q8NGS2; 1 site.
DR BioMuta; OR1J2; -.
DR DMDM; 38372761; -.
DR MassIVE; Q8NGS2; -.
DR PaxDb; Q8NGS2; -.
DR PeptideAtlas; Q8NGS2; -.
DR PRIDE; Q8NGS2; -.
DR Antibodypedia; 66861; 26 antibodies from 10 providers.
DR DNASU; 26740; -.
DR Ensembl; ENST00000335302.5; ENSP00000335575.5; ENSG00000197233.7.
DR GeneID; 26740; -.
DR KEGG; hsa:26740; -.
DR MANE-Select; ENST00000335302.5; ENSP00000335575.5; NM_054107.1; NP_473448.1.
DR UCSC; uc011lyv.2; human.
DR CTD; 26740; -.
DR DisGeNET; 26740; -.
DR GeneCards; OR1J2; -.
DR HGNC; HGNC:8209; OR1J2.
DR HPA; ENSG00000197233; Not detected.
DR neXtProt; NX_Q8NGS2; -.
DR OpenTargets; ENSG00000197233; -.
DR PharmGKB; PA32080; -.
DR VEuPathDB; HostDB:ENSG00000197233; -.
DR eggNOG; ENOG502T8AD; Eukaryota.
DR GeneTree; ENSGT00940000163995; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8NGS2; -.
DR OMA; ANTIPHV; -.
DR PhylomeDB; Q8NGS2; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGS2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26740; 9 hits in 665 CRISPR screens.
DR ChiTaRS; OR1J2; human.
DR GeneWiki; OR1J2; -.
DR GenomeRNAi; 26740; -.
DR Pharos; Q8NGS2; Tdark.
DR PRO; PR:Q8NGS2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGS2; protein.
DR Bgee; ENSG00000197233; Expressed in buccal mucosa cell and 6 other tissues.
DR ExpressionAtlas; Q8NGS2; baseline and differential.
DR Genevisible; Q8NGS2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 1J2"
FT /id="PRO_0000150439"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 119
FT /note="A -> T (in dbSNP:rs41277120)"
FT /id="VAR_062010"
FT VARIANT 165
FT /note="R -> Q (in dbSNP:rs4836891)"
FT /id="VAR_053123"
FT CONFLICT 148
FT /note="S -> T (in Ref. 5; AAF40352)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35385 MW; 8408D57426DA3001 CRC64;
MSPENQSSVS EFLLLGLPIR PEQQAVFFTL FLGMYLTTVL GNLLIMLLIQ LDSHLHTPMY
FFLSHLALTD ISFSSVTVPK MLMDMRTKYK SILYEECISQ MYFFIFFTDL DSFLITSMAY
DRYVAICHPL HYTVIMREEL CVFLVAVSWI LSCASSLSHT LLLTRLSFCA ANTIPHVFCD
LAALLKLSCS DIFLNELVMF TVGVVVITLP FMCILVSYGY IGATILRVPS TKGIHKALST
CGSHLSVVSL YYGSIFGQYL FPTVSSSIDK DVIVALMYTV VTPMLNPFIY SLRNRDMKEA
LGKLFSRATF FSW
