OR1L1_HUMAN
ID OR1L1_HUMAN Reviewed; 360 AA.
AC Q8NH94; Q5T7Z3; Q6IFN2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 1L1;
DE AltName: Full=Olfactory receptor 1L2;
DE AltName: Full=Olfactory receptor 9-C;
DE Short=OR9-C;
DE AltName: Full=Olfactory receptor OR9-27;
GN Name=OR1L1; Synonyms=OR1L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-145 AND VAL-308.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, AND VARIANTS GLY-145 AND VAL-308.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-51 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05743.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW87540.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L1";
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DR EMBL; AB065491; BAC05743.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87540.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK004230; DAA04628.1; -; Genomic_DNA.
DR RefSeq; NP_001005236.3; NM_001005236.3.
DR AlphaFoldDB; Q8NH94; -.
DR SMR; Q8NH94; -.
DR STRING; 9606.ENSP00000310773; -.
DR GlyGen; Q8NH94; 2 sites.
DR iPTMnet; Q8NH94; -.
DR PhosphoSitePlus; Q8NH94; -.
DR BioMuta; OR1L1; -.
DR DMDM; 229462947; -.
DR jPOST; Q8NH94; -.
DR MassIVE; Q8NH94; -.
DR PaxDb; Q8NH94; -.
DR PeptideAtlas; Q8NH94; -.
DR PRIDE; Q8NH94; -.
DR Antibodypedia; 66869; 24 antibodies from 13 providers.
DR DNASU; 26737; -.
DR Ensembl; ENST00000373686.1; ENSP00000362790.1; ENSG00000173679.2.
DR GeneID; 26737; -.
DR KEGG; hsa:26737; -.
DR UCSC; uc064vng.1; human.
DR CTD; 26737; -.
DR GeneCards; OR1L1; -.
DR HGNC; HGNC:8213; OR1L1.
DR HPA; ENSG00000173679; Not detected.
DR neXtProt; NX_Q8NH94; -.
DR PharmGKB; PA32084; -.
DR VEuPathDB; HostDB:ENSG00000173679; -.
DR eggNOG; ENOG502T9M9; Eukaryota.
DR GeneTree; ENSGT00940000164453; -.
DR InParanoid; Q8NH94; -.
DR OrthoDB; 1001167at2759; -.
DR PhylomeDB; Q8NH94; -.
DR PathwayCommons; Q8NH94; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26737; 10 hits in 668 CRISPR screens.
DR GeneWiki; OR1L1; -.
DR GenomeRNAi; 26737; -.
DR Pharos; Q8NH94; Tdark.
DR PRO; PR:Q8NH94; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NH94; protein.
DR Bgee; ENSG00000173679; Expressed in urinary bladder and 1 other tissue.
DR ExpressionAtlas; Q8NH94; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="Olfactory receptor 1L1"
FT /id="PRO_0000150442"
FT TOPO_DOM 1..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..99
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..170
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..208
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..269
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..309
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 147..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 145
FT /note="S -> G (in dbSNP:rs70157)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_047141"
FT VARIANT 149
FT /note="T -> A (in dbSNP:rs16912055)"
FT /id="VAR_047142"
FT VARIANT 308
FT /note="L -> V (in dbSNP:rs237620)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_047143"
FT VARIANT 349
FT /note="G -> R (in dbSNP:rs16912062)"
FT /id="VAR_047144"
SQ SEQUENCE 360 AA; 41046 MW; 0C4C894477361176 CRC64;
MERNHNPDNC NVLNFFFADK KNKRRNFGQI VSDVGRICYS VSLSLGEPTT MGRNNLTRPS
EFILLGLSSR PEDQKPLFAV FLPIYLITVI GNLLIILAIR SDTRLQTPMY FFLSILSFVD
ICYVTVIIPK MLVNFLSETK TISYSECLTQ MYFFLAFGNT DSYLLAAMAI DRYVAICNPF
HYITIMSHRC CVLLLVLSFC IPHFHSLLHI LLTNQLIFCA SNVIHHFFCD DQPVLKLSCS
SHFVKEITVM TEGLAVIMTP FSCIIISYLR ILITVLKIPS AAGKRKAFST CGSHLTVVTL
FYGSISYLYF QPLSNYTVKD QIATIIYTVL TPMLNPFIYS LRNKDMKQGL AKLMHRMKCQ
