OR1L4_HUMAN
ID OR1L4_HUMAN Reviewed; 311 AA.
AC Q8NGR5; Q6IFN0; Q96R81;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 1L4;
DE AltName: Full=OST046;
DE AltName: Full=Olfactory receptor 1L5;
DE AltName: Full=Olfactory receptor 9-E;
DE Short=OR9-E;
DE AltName: Full=Olfactory receptor OR9-29;
GN Name=OR1L4; Synonyms=OR1L5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, AND VARIANT ARG-234.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L4";
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DR EMBL; AB065724; BAC05945.1; -; Genomic_DNA.
DR EMBL; AF399562; AAK95047.1; -; Genomic_DNA.
DR EMBL; BK004232; DAA04630.1; -; Genomic_DNA.
DR CCDS; CCDS35129.1; -.
DR RefSeq; NP_001005235.1; NM_001005235.1.
DR AlphaFoldDB; Q8NGR5; -.
DR SMR; Q8NGR5; -.
DR STRING; 9606.ENSP00000259466; -.
DR GlyGen; Q8NGR5; 1 site.
DR iPTMnet; Q8NGR5; -.
DR PhosphoSitePlus; Q8NGR5; -.
DR BioMuta; OR1L4; -.
DR DMDM; 38372755; -.
DR MassIVE; Q8NGR5; -.
DR PaxDb; Q8NGR5; -.
DR PRIDE; Q8NGR5; -.
DR Antibodypedia; 72099; 20 antibodies from 14 providers.
DR DNASU; 254973; -.
DR Ensembl; ENST00000259466.1; ENSP00000259466.1; ENSG00000136939.1.
DR GeneID; 254973; -.
DR KEGG; hsa:254973; -.
DR MANE-Select; ENST00000259466.1; ENSP00000259466.1; NM_001005235.1; NP_001005235.1.
DR UCSC; uc004bmu.1; human.
DR CTD; 254973; -.
DR GeneCards; OR1L4; -.
DR HGNC; HGNC:8216; OR1L4.
DR HPA; ENSG00000136939; Not detected.
DR neXtProt; NX_Q8NGR5; -.
DR OpenTargets; ENSG00000136939; -.
DR PharmGKB; PA32086; -.
DR VEuPathDB; HostDB:ENSG00000136939; -.
DR eggNOG; ENOG502RTXQ; Eukaryota.
DR GeneTree; ENSGT00940000165463; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8NGR5; -.
DR OMA; SMYSVMK; -.
DR OrthoDB; 935128at2759; -.
DR PhylomeDB; Q8NGR5; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGR5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 254973; 9 hits in 668 CRISPR screens.
DR GeneWiki; OR1L4; -.
DR GenomeRNAi; 254973; -.
DR Pharos; Q8NGR5; Tdark.
DR PRO; PR:Q8NGR5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGR5; protein.
DR Bgee; ENSG00000136939; Expressed in sural nerve and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 1L4"
FT /id="PRO_0000150444"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 234
FT /note="G -> R (in dbSNP:rs2215530)"
FT /evidence="ECO:0000269|PubMed:12213199"
FT /id="VAR_053124"
FT VARIANT 310
FT /note="Y -> H (in dbSNP:rs12341025)"
FT /id="VAR_053125"
SQ SEQUENCE 311 AA; 35277 MW; 2CF7C78F0D435399 CRC64;
METKNYSSST SGFILLGLSS NPKLQKPLFA IFLIMYLLTA VGNVLIILAI YSDPRLHTPM
YFFLSNLSFM DICFTTVIVP KMLVNFLSET KIISYVGCLI QMYFFMAFGN TDSYLLASMA
IDRLVAICNP LHYDVVMKPW HCLLMLLGSC SISHLHSLFR VLLMSRLSFC ASHIIKHFFC
DTQPVLKLSC SDTSSSQMVV MTETLAVIVT PFLCTIFSYL QIIVTVLRIP SAAGKWKAFS
TCGSHLTVVV LFYGSVIYVY FRPLSMYSVM KGRVATVMYT VVTPMLNPFI YSLRNKDMKR
GLKKLRHRIY S
