OR1L6_HUMAN
ID OR1L6_HUMAN Reviewed; 347 AA.
AC Q8NGR2; Q6IFM8; Q96R80;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 1L6;
DE AltName: Full=Olfactory receptor 1L7;
DE AltName: Full=Olfactory receptor OR9-30;
GN Name=OR1L6; Synonyms=OR1L7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-37 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L6";
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DR EMBL; AB065727; BAC05948.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC006313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399563; AAK95048.1; -; Genomic_DNA.
DR EMBL; BK004234; DAA04632.1; -; Genomic_DNA.
DR RefSeq; NP_001004453.2; NM_001004453.2.
DR AlphaFoldDB; Q8NGR2; -.
DR SMR; Q8NGR2; -.
DR STRING; 9606.ENSP00000304235; -.
DR GlyGen; Q8NGR2; 1 site.
DR iPTMnet; Q8NGR2; -.
DR PhosphoSitePlus; Q8NGR2; -.
DR BioMuta; OR1L6; -.
DR DMDM; 229462929; -.
DR MassIVE; Q8NGR2; -.
DR PaxDb; Q8NGR2; -.
DR PRIDE; Q8NGR2; -.
DR Antibodypedia; 64335; 45 antibodies from 14 providers.
DR DNASU; 392390; -.
DR Ensembl; ENST00000373684.1; ENSP00000362788.1; ENSG00000171459.4.
DR GeneID; 392390; -.
DR KEGG; hsa:392390; -.
DR UCSC; uc022bna.1; human.
DR CTD; 392390; -.
DR GeneCards; OR1L6; -.
DR HGNC; HGNC:8218; OR1L6.
DR HPA; ENSG00000171459; Not detected.
DR neXtProt; NX_Q8NGR2; -.
DR PharmGKB; PA32087; -.
DR VEuPathDB; HostDB:ENSG00000171459; -.
DR eggNOG; ENOG502RTXQ; Eukaryota.
DR GeneTree; ENSGT00940000165463; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGR2; -.
DR OrthoDB; 935128at2759; -.
DR PhylomeDB; Q8NGR2; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGR2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 392390; 5 hits in 653 CRISPR screens.
DR GeneWiki; OR1L6; -.
DR GenomeRNAi; 392390; -.
DR Pharos; Q8NGR2; Tdark.
DR PRO; PR:Q8NGR2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGR2; protein.
DR Bgee; ENSG00000171459; Expressed in sural nerve and 1 other tissue.
DR ExpressionAtlas; Q8NGR2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Olfactory receptor 1L6"
FT /id="PRO_0000150445"
FT TOPO_DOM 1..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..86
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..116
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..157
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..195
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..329
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 59
FT /note="Q -> K (in dbSNP:rs10760252)"
FT /id="VAR_055056"
FT VARIANT 186
FT /note="C -> Y (in dbSNP:rs4838012)"
FT /id="VAR_055057"
FT VARIANT 251
FT /note="I -> T (in dbSNP:rs10985760)"
FT /id="VAR_055058"
FT VARIANT 259
FT /note="M -> I (in dbSNP:rs10818741)"
FT /id="VAR_055059"
SQ SEQUENCE 347 AA; 39515 MW; 12DBD2BBC6CD3270 CRC64;
MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI LLGLSSNPQL
QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL SNLSFMDICF TTVIVPKMLV
NFLSETKVIS YVGCLAQMYF FMAFGNTDSY LLASMAIDRL VAICNPLHYD VVMKPRHCLL
MLLGSCSISH LHSLFRVLLM SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET
LAVIVTPFLC IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR
