OR1M1_HUMAN
ID OR1M1_HUMAN Reviewed; 313 AA.
AC Q8NGA1; B9EHA6; Q6IFJ3; Q96R91;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 1M1;
DE AltName: Full=Olfactory receptor 19-6;
DE Short=OR19-6;
DE AltName: Full=Olfactory receptor OR19-5;
GN Name=OR1M1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1M1";
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DR EMBL; AB065925; BAC06140.1; -; Genomic_DNA.
DR EMBL; BC137551; AAI37552.1; -; mRNA.
DR EMBL; BC137555; AAI37556.1; -; mRNA.
DR EMBL; AF399549; AAK95034.1; -; Genomic_DNA.
DR EMBL; BK004269; DAA04667.1; -; Genomic_DNA.
DR CCDS; CCDS32896.1; -.
DR RefSeq; NP_001004456.1; NM_001004456.1.
DR AlphaFoldDB; Q8NGA1; -.
DR SMR; Q8NGA1; -.
DR BioGRID; 125939; 38.
DR STRING; 9606.ENSP00000401966; -.
DR GlyGen; Q8NGA1; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NGA1; -.
DR PhosphoSitePlus; Q8NGA1; -.
DR BioMuta; OR1M1; -.
DR DMDM; 38372651; -.
DR jPOST; Q8NGA1; -.
DR MassIVE; Q8NGA1; -.
DR MaxQB; Q8NGA1; -.
DR PaxDb; Q8NGA1; -.
DR PeptideAtlas; Q8NGA1; -.
DR PRIDE; Q8NGA1; -.
DR ProteomicsDB; 73459; -.
DR Antibodypedia; 24990; 69 antibodies from 18 providers.
DR DNASU; 125963; -.
DR Ensembl; ENST00000429566.3; ENSP00000401966.2; ENSG00000170929.6.
DR Ensembl; ENST00000641627.1; ENSP00000493107.1; ENSG00000170929.6.
DR GeneID; 125963; -.
DR KEGG; hsa:125963; -.
DR MANE-Select; ENST00000641627.1; ENSP00000493107.1; NM_001004456.2; NP_001004456.1.
DR UCSC; uc010xkj.3; human.
DR CTD; 125963; -.
DR GeneCards; OR1M1; -.
DR HGNC; HGNC:8220; OR1M1.
DR HPA; ENSG00000170929; Tissue enriched (brain).
DR neXtProt; NX_Q8NGA1; -.
DR OpenTargets; ENSG00000170929; -.
DR PharmGKB; PA32089; -.
DR VEuPathDB; HostDB:ENSG00000170929; -.
DR eggNOG; ENOG502T9JZ; Eukaryota.
DR GeneTree; ENSGT00940000163044; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGA1; -.
DR OMA; FCGNNEL; -.
DR OrthoDB; 875656at2759; -.
DR PhylomeDB; Q8NGA1; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGA1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 125963; 7 hits in 670 CRISPR screens.
DR ChiTaRS; OR1M1; human.
DR GeneWiki; OR1M1; -.
DR GenomeRNAi; 125963; -.
DR Pharos; Q8NGA1; Tdark.
DR PRO; PR:Q8NGA1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NGA1; protein.
DR Bgee; ENSG00000170929; Expressed in olfactory segment of nasal mucosa and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 1M1"
FT /id="PRO_0000150447"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 34840 MW; 2B965387C73074C4 CRC64;
MEPRNQTSAS QFILLGLSEK PEQETLLFSL FFCMYLVMVV GNLLIILAIS IDSHLHTPMY
FFLANLSLVD FCLATNTIPK MLVSLQTGSK AISYPCCLIQ MYFFHFFGIV DSVIIAMMAY
DRFVAICHPL HYAKIMSLRL CRLLVGALWA FSCFISLTHI LLMARLVFCG SHEVPHYFCD
LTPILRLSCT DTSVNRIFIL IVAGMVIATP FVCILASYAR ILVAIMKVPS AGGRKKAFST
CSSHLSVVAL FYGTTIGVYL CPSSVLTTVK EKASAVMYTA VTPMLNPFIY SLRNRDLKGA
LRKLVNRKIT SSS
