OR1N1_HUMAN
ID OR1N1_HUMAN Reviewed; 311 AA.
AC Q8NGS0; A3KFM1; O43870; Q6IF16; Q96R93;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 1N1;
DE AltName: Full=Olfactory receptor 1-26;
DE Short=OR1-26;
DE AltName: Full=Olfactory receptor 1N3;
DE AltName: Full=Olfactory receptor OR9-22;
GN Name=OR1N1; Synonyms=OR1N3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-190.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1N1";
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DR EMBL; AB065719; BAC05940.1; -; Genomic_DNA.
DR EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87534.1; -; Genomic_DNA.
DR EMBL; U86216; AAC39612.1; -; Genomic_DNA.
DR EMBL; AF399547; AAK95032.1; -; Genomic_DNA.
DR EMBL; BK004446; DAA04844.1; -; Genomic_DNA.
DR CCDS; CCDS6844.1; -.
DR RefSeq; NP_036495.1; NM_012363.1.
DR AlphaFoldDB; Q8NGS0; -.
DR SMR; Q8NGS0; -.
DR BioGRID; 126530; 45.
DR STRING; 9606.ENSP00000306974; -.
DR GlyGen; Q8NGS0; 1 site.
DR BioMuta; OR1N1; -.
DR DMDM; 38372759; -.
DR MassIVE; Q8NGS0; -.
DR PaxDb; Q8NGS0; -.
DR PeptideAtlas; Q8NGS0; -.
DR PRIDE; Q8NGS0; -.
DR ProteomicsDB; 73587; -.
DR Antibodypedia; 57807; 103 antibodies from 22 providers.
DR DNASU; 138883; -.
DR Ensembl; ENST00000304880.2; ENSP00000306974.2; ENSG00000171505.5.
DR GeneID; 138883; -.
DR KEGG; hsa:138883; -.
DR MANE-Select; ENST00000304880.2; ENSP00000306974.2; NM_012363.1; NP_036495.1.
DR UCSC; uc004bmn.1; human.
DR CTD; 138883; -.
DR DisGeNET; 138883; -.
DR GeneCards; OR1N1; -.
DR HGNC; HGNC:8221; OR1N1.
DR HPA; ENSG00000171505; Not detected.
DR neXtProt; NX_Q8NGS0; -.
DR OpenTargets; ENSG00000171505; -.
DR PharmGKB; PA32090; -.
DR VEuPathDB; HostDB:ENSG00000171505; -.
DR eggNOG; ENOG502T9KE; Eukaryota.
DR GeneTree; ENSGT00940000163451; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGS0; -.
DR OMA; LCWVLTH; -.
DR OrthoDB; 1012220at2759; -.
DR PhylomeDB; Q8NGS0; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGS0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 138883; 11 hits in 666 CRISPR screens.
DR GeneWiki; OR1N1; -.
DR GenomeRNAi; 138883; -.
DR Pharos; Q8NGS0; Tdark.
DR PRO; PR:Q8NGS0; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGS0; protein.
DR Bgee; ENSG00000171505; Expressed in ganglionic eminence and 7 other tissues.
DR ExpressionAtlas; Q8NGS0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 1N1"
FT /id="PRO_0000150448"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 18
FT /note="P -> S (in dbSNP:rs10818708)"
FT /id="VAR_024089"
FT VARIANT 190
FT /note="T -> N (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036208"
FT VARIANT 227
FT /note="R -> Q (in dbSNP:rs58226717)"
FT /id="VAR_062011"
FT CONFLICT 91
FT /note="S -> T (in Ref. 4; AAC39612)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 34650 MW; 6B82AE0B4A836180 CRC64;
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD LHLHTPMYFF
LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY FFLMFGDLDS FFLAAMAYDR
YVAICHPLCY STVMRPQVCA LMLALCWVLT NIVALTHTFL MARLSFCVTG EIAHFFCDIT
PVLKLSCSDT HINEMMVFVL GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS
SHLCVVCVFY GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK
RLFSHRSIVS S
