OR1N2_HUMAN
ID OR1N2_HUMAN Reviewed; 330 AA.
AC Q8NGR9; A3KFM2; B2RNY4; Q6IF17; Q96RA3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 1N2;
DE AltName: Full=Olfactory receptor OR9-23;
GN Name=OR1N2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-37; GLY-244 AND
RP MET-301.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-301.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05941.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1N2";
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DR EMBL; AB065720; BAC05941.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137182; AAI37183.1; -; mRNA.
DR EMBL; BC137183; AAI37184.1; -; mRNA.
DR EMBL; AF399536; AAK95021.1; -; Genomic_DNA.
DR EMBL; BK004445; DAA04843.1; -; Genomic_DNA.
DR RefSeq; NP_001004457.1; NM_001004457.1.
DR AlphaFoldDB; Q8NGR9; -.
DR SMR; Q8NGR9; -.
DR STRING; 9606.ENSP00000362792; -.
DR GlyGen; Q8NGR9; 1 site.
DR iPTMnet; Q8NGR9; -.
DR PhosphoSitePlus; Q8NGR9; -.
DR BioMuta; OR1N2; -.
DR DMDM; 218511727; -.
DR MassIVE; Q8NGR9; -.
DR PaxDb; Q8NGR9; -.
DR PRIDE; Q8NGR9; -.
DR Antibodypedia; 30315; 73 antibodies from 15 providers.
DR DNASU; 138882; -.
DR Ensembl; ENST00000616791.3; ENSP00000483293.3; ENSG00000171501.10.
DR GeneID; 138882; -.
DR KEGG; hsa:138882; -.
DR UCSC; uc011lyx.3; human.
DR CTD; 138882; -.
DR GeneCards; OR1N2; -.
DR HGNC; HGNC:15111; OR1N2.
DR HPA; ENSG00000171501; Not detected.
DR neXtProt; NX_Q8NGR9; -.
DR PharmGKB; PA32091; -.
DR VEuPathDB; HostDB:ENSG00000171501; -.
DR eggNOG; ENOG502SMIM; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGR9; -.
DR OrthoDB; 889217at2759; -.
DR PhylomeDB; Q8NGR9; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGR9; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 138882; 10 hits in 671 CRISPR screens.
DR GeneWiki; OR1N2; -.
DR GenomeRNAi; 138882; -.
DR Pharos; Q8NGR9; Tdark.
DR PRO; PR:Q8NGR9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGR9; protein.
DR ExpressionAtlas; Q8NGR9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 1N2"
FT /id="PRO_0000150449"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..236
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 37
FT /note="W -> R (in dbSNP:rs1831370)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_048028"
FT VARIANT 237
FT /note="R -> C (in dbSNP:rs41316976)"
FT /id="VAR_062012"
FT VARIANT 244
FT /note="V -> G (in dbSNP:rs1341044)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_048029"
FT VARIANT 301
FT /note="T -> M (in dbSNP:rs1411272)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_048030"
SQ SEQUENCE 330 AA; 36889 MW; 242D45D016841C4A CRC64;
MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG MYLVTMVGNL
LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA NIHTQSQIIS YSGCLAQLYF
LLMFGGLDNC LLAVMAYDRY VAICQPLHYS TSMSPQLCAL MLGVCWVLTN CPALMHTLLL
TRVAFCAQKA IPHFYCDPSA LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW
AVFVISSPGG RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP
TLNPFIYSLR NRDMKEALGK LFVSGKTFFL
