OR1Q1_HUMAN
ID OR1Q1_HUMAN Reviewed; 314 AA.
AC Q15612; Q6IFN4; Q8NGR7; Q96R82;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Olfactory receptor 1Q1;
DE AltName: Full=OST226;
DE AltName: Full=Olfactory receptor 1Q2;
DE AltName: Full=Olfactory receptor 1Q3;
DE AltName: Full=Olfactory receptor 9-A;
DE Short=OR9-A;
DE AltName: Full=Olfactory receptor OR9-25;
DE AltName: Full=Olfactory receptor TPCR106;
GN Name=OR1Q1; Synonyms=OR1Q2, OR1Q3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANT MET-163.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, AND VARIANT MET-163.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1Q1";
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DR EMBL; AB065722; BAC05943.1; -; Genomic_DNA.
DR EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399561; AAK95046.1; -; Genomic_DNA.
DR EMBL; X89667; CAA61814.1; -; mRNA.
DR EMBL; BK004228; DAA04626.1; -; Genomic_DNA.
DR CCDS; CCDS35125.1; -.
DR PIR; S58012; S58012.
DR RefSeq; NP_036496.1; NM_012364.1.
DR AlphaFoldDB; Q15612; -.
DR SMR; Q15612; -.
DR STRING; 9606.ENSP00000297913; -.
DR GlyGen; Q15612; 1 site.
DR iPTMnet; Q15612; -.
DR PhosphoSitePlus; Q15612; -.
DR BioMuta; OR1Q1; -.
DR DMDM; 85681882; -.
DR MassIVE; Q15612; -.
DR PaxDb; Q15612; -.
DR PRIDE; Q15612; -.
DR Antibodypedia; 30322; 66 antibodies from 16 providers.
DR DNASU; 158131; -.
DR Ensembl; ENST00000297913.3; ENSP00000297913.2; ENSG00000165202.3.
DR GeneID; 158131; -.
DR KEGG; hsa:158131; -.
DR MANE-Select; ENST00000297913.3; ENSP00000297913.2; NM_012364.1; NP_036496.1.
DR UCSC; uc011lyy.2; human.
DR CTD; 158131; -.
DR GeneCards; OR1Q1; -.
DR HGNC; HGNC:8223; OR1Q1.
DR HPA; ENSG00000165202; Tissue enhanced (retina).
DR neXtProt; NX_Q15612; -.
DR PharmGKB; PA32094; -.
DR VEuPathDB; HostDB:ENSG00000165202; -.
DR eggNOG; ENOG502T9KC; Eukaryota.
DR GeneTree; ENSGT00940000163649; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q15612; -.
DR OMA; MGCLAQT; -.
DR PhylomeDB; Q15612; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q15612; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 158131; 7 hits in 663 CRISPR screens.
DR GeneWiki; OR1Q1; -.
DR GenomeRNAi; 158131; -.
DR Pharos; Q15612; Tdark.
DR PRO; PR:Q15612; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q15612; protein.
DR Bgee; ENSG00000165202; Expressed in stromal cell of endometrium and 15 other tissues.
DR Genevisible; Q15612; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 1Q1"
FT /id="PRO_0000150450"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 24
FT /note="Q -> R (in dbSNP:rs972925)"
FT /id="VAR_053126"
FT VARIANT 163
FT /note="I -> M (in dbSNP:rs1329957)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:9119360"
FT /id="VAR_024768"
FT VARIANT 240
FT /note="T -> A (in dbSNP:rs727913)"
FT /id="VAR_053127"
FT CONFLICT 126
FT /note="I -> F (in Ref. 4; CAA61814)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35598 MW; 6CFA2B4C946F0EBB CRC64;
MDNSNWTSVS HFVLLGISTH PEEQIPLFLV FSLMYAINIS GNLAIITLIL SAPRLHIPMY
IFLSNLALTD ICFTSTTVPK MLQIIFSPTK VISYTGCLAQ TYFFICFAVM ENFILAVMAY
DRYIAICHPF HYTMILTRML CVKMVVMCHA LSHLHAMLHT FLIGQLIFCA DNRIPHFFCD
LYALMKISCT STYLNTLMIH TEGAVVISGA LAFITASYAC IILVVLRIPS AKGRWKTFST
CGSHLTVVAI FYGTLSWVYF RPLSSYSVTK GRIITVVYTV VTPMLNPFIY SLRNGDVKGG
FMKWMSRMQT FFFR
