OR1S2_HUMAN
ID OR1S2_HUMAN Reviewed; 325 AA.
AC Q8NGQ3; Q6IFG5; Q96R85;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 1S2;
DE AltName: Full=Olfactory receptor OR11-231;
GN Name=OR1S2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05957.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1S2";
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DR EMBL; AB065736; BAC05957.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF399557; AAK95042.1; -; Genomic_DNA.
DR EMBL; BK004297; DAA04695.1; -; Genomic_DNA.
DR RefSeq; NP_001004459.1; NM_001004459.1.
DR AlphaFoldDB; Q8NGQ3; -.
DR SMR; Q8NGQ3; -.
DR STRING; 9606.ENSP00000305469; -.
DR GlyGen; Q8NGQ3; 1 site.
DR iPTMnet; Q8NGQ3; -.
DR PhosphoSitePlus; Q8NGQ3; -.
DR BioMuta; OR1S2; -.
DR DMDM; 223590115; -.
DR PaxDb; Q8NGQ3; -.
DR PeptideAtlas; Q8NGQ3; -.
DR PRIDE; Q8NGQ3; -.
DR Antibodypedia; 58756; 78 antibodies from 22 providers.
DR DNASU; 219958; -.
DR GeneID; 219958; -.
DR KEGG; hsa:219958; -.
DR UCSC; uc010rkb.3; human.
DR CTD; 219958; -.
DR GeneCards; OR1S2; -.
DR HGNC; HGNC:15141; OR1S2.
DR HPA; ENSG00000197887; Not detected.
DR neXtProt; NX_Q8NGQ3; -.
DR PharmGKB; PA32099; -.
DR VEuPathDB; HostDB:ENSG00000197887; -.
DR eggNOG; ENOG502RQAM; Eukaryota.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGQ3; -.
DR OrthoDB; 892474at2759; -.
DR PhylomeDB; Q8NGQ3; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGQ3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219958; 4 hits in 614 CRISPR screens.
DR GeneWiki; OR1S2; -.
DR GenomeRNAi; 219958; -.
DR Pharos; Q8NGQ3; Tdark.
DR PRO; PR:Q8NGQ3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGQ3; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 1S2"
FT /id="PRO_0000150452"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 59
FT /note="I -> T (in dbSNP:rs11229281)"
FT /id="VAR_062013"
FT VARIANT 225
FT /note="V -> A (in dbSNP:rs11229277)"
FT /id="VAR_059980"
FT VARIANT 225
FT /note="V -> I (in dbSNP:rs11229278)"
FT /id="VAR_059981"
SQ SEQUENCE 325 AA; 36579 MW; C76BB6A38929EBB1 CRC64;
MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV TVVGNGLIIV
AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT NSQSISYESC ITQMYFSIVF
VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR ARFGTLLTVI SWFLSNIIAL THTLLLIQLL
FCDHNTLPHF FCDLAPLLKL SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG
VSSTQGKWKA FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP
FIYSLRNKDM KGALRKLINR KISSL
