OR1_ANOGA
ID OR1_ANOGA Reviewed; 417 AA.
AC Q8WTE7; Q6VPM5; Q7Q1T3;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Odorant receptor Or1;
DE AltName: Full=AgOr1;
GN Name=OR1; ORFNames=AGAP009640;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000312|EMBL:AAL35506.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=G3 {ECO:0000269|PubMed:11724964};
RX PubMed=11724964; DOI=10.1073/pnas.261432998;
RA Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.;
RT "Candidate odorant receptors from the malaria vector mosquito Anopheles
RT gambiae and evidence of down-regulation in response to blood feeding.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
RC STRAIN=4aRR, L3-5, and Yaounde;
RX PubMed=15642974; DOI=10.4269/ajtmh.2004.71.795;
RA Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.;
RT "Intraspecific nucleotide variation in Anopheles gambiae: new insights into
RT the biology of malaria vectors.";
RL Am. J. Trop. Med. Hyg. 71:795-802(2004).
RN [4] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=14724626; DOI=10.1038/427212a;
RA Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.;
RT "Olfaction: mosquito receptor for human-sweat odorant.";
RL Nature 427:212-213(2004).
RN [5] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12364795; DOI=10.1126/science.1076196;
RA Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A.,
RA Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J.;
RT "G protein-coupled receptors in Anopheles gambiae.";
RL Science 298:176-178(2002).
CC -!- FUNCTION: Odorant receptor which plays a critical role in the
CC anthropophilic host-seeking behavior; establishes the host preference
CC to transmit malaria. May participate in the phenomenon of decreased
CC host-seeking behavior in disease vector mosquitoes after blood feeding.
CC {ECO:0000269|PubMed:11724964, ECO:0000269|PubMed:14724626}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Female-specific antennae and maxillary palp
CC expression. {ECO:0000269|PubMed:11724964, ECO:0000269|PubMed:12364795}.
CC -!- INDUCTION: Strong response to the odorant 4-methylphenol, a component
CC of human sweat, when expressed in odorant receptor deficient
CC Drosophila. In vivo, decreased expression in antennae after a blood
CC meal. {ECO:0000269|PubMed:11724964, ECO:0000269|PubMed:14724626}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=What mosquitoes sniff
CC - Issue 44 of March 2004;
CC URL="https://web.expasy.org/spotlight/back_issues/044";
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DR EMBL; AF364130; AAL35506.1; -; Genomic_DNA.
DR EMBL; AAAB01008980; EAA13838.1; -; Genomic_DNA.
DR EMBL; AY334005; AAR01130.1; -; Genomic_DNA.
DR EMBL; AY334006; AAR01131.1; -; Genomic_DNA.
DR EMBL; AY334007; AAR01132.1; -; Genomic_DNA.
DR RefSeq; XP_318674.1; XM_318674.1.
DR AlphaFoldDB; Q8WTE7; -.
DR SMR; Q8WTE7; -.
DR PaxDb; Q8WTE7; -.
DR GeneID; 1279017; -.
DR KEGG; aga:AgaP_AGAP009640; -.
DR CTD; 1279017; -.
DR VEuPathDB; VectorBase:AGAP009640; -.
DR eggNOG; ENOG502TBE3; Eukaryota.
DR InParanoid; Q8WTE7; -.
DR OMA; WHLLGLE; -.
DR OrthoDB; 745330at2759; -.
DR PhylomeDB; Q8WTE7; -.
DR Proteomes; UP000007062; Chromosome 3R.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; IDA:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0042048; P:olfactory behavior; IDA:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IDA:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..417
FT /note="Odorant receptor Or1"
FT /id="PRO_0000174286"
FT TOPO_DOM 1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..417
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="M -> V (in Ref. 3; AAR01130/AAR01131/AAR01132)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="Q -> R (in Ref. 3; AAR01130/AAR01131/AAR01132)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="H -> R (in Ref. 3; AAR01130/AAR01131/AAR01132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 48520 MW; F60D7D7BD93D37F2 CRC64;
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW ALRIMFLHLY
ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN IARIQACLRK LNCTLYHPKQ
REEFSPVLQS MSGVFWLMIF LMFVAIFTII MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV
YGVLFLYQTI GIVMSATYNF STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT
DAEWKEMRKR IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT EFVGFSNYFK
FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI MKLSYSYLAV LQSMESE
