OR22A_DROME
ID OR22A_DROME Reviewed; 397 AA.
AC P81909; B7VC05; B7VC07; B7VC09; B7VC11; B7VC21; B7VC27; B7VC29; B7VC75;
AC B7VC77; B7VCA5; Q9U6X7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1999, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Odorant receptor 22a;
GN Name=Or22a; Synonyms=AN11, DOR22A.1, dor53, Or22A.1; ORFNames=CG12193;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Berkeley;
RX PubMed=10458908; DOI=10.1006/geno.1999.5894;
RA Gao Q., Chess A.;
RT "Identification of candidate Drosophila olfactory receptors from genomic
RT DNA sequence.";
RL Genomics 60:31-39(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TYR-8; ILE-59; MET-67;
RP VAL-93; SER-100; LEU-102; ALA-196; GLU-201; ASN-220; SER-292; ALA-328;
RP ASP-329; SER-330; ILE-359; ASN-375; THR-382; ALA-385; ILE-386; VAL-387 AND
RP LYS-395.
RC STRAIN=CN1, CN13, CN14, CN18, CN21, CN28, CN29, CN3, CN43, CN45, CN46,
RC CN51, LA108, LA120, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35, LA4,
RC LA6, LA9, MA21, MA24, MA43, MA74, NC100b, NC10b, NC16a, NC1b, NC37a, NC84a,
RC NC88a, NC89a, and NC97a;
RX PubMed=18922763; DOI=10.1093/molbev/msn227;
RA Aguade M.;
RT "Nucleotide and copy-number polymorphism at the odorant receptor genes
RT Or22a and Or22b in Drosophila melanogaster.";
RL Mol. Biol. Evol. 26:61-70(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-397, AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R; TISSUE=Antenna;
RX PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
RA Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RT "A spatial map of olfactory receptor expression in the Drosophila
RT antenna.";
RL Cell 96:725-736(1999).
RN [6]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RC TISSUE=Antenna;
RX PubMed=10069338; DOI=10.1016/s0896-6273(00)81093-4;
RA Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
RT "A novel family of divergent seven-transmembrane proteins: candidate
RT odorant receptors in Drosophila.";
RL Neuron 22:327-338(1999).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA Vosshall L.B., Wong A.M., Axel R.;
RT "An olfactory sensory map in the fly brain.";
RL Cell 102:147-159(2000).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12628173; DOI=10.1016/s0896-6273(03)00094-1;
RA Dobritsa A.A., van der Goes van Naters W., Warr C.G., Steinbrecht R.A.,
RA Carlson J.R.;
RT "Integrating the molecular and cellular basis of odor coding in the
RT Drosophila antenna.";
RL Neuron 37:827-841(2003).
RN [9]
RP FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
RX PubMed=15592462; DOI=10.1038/nn1371;
RA Neuhaus E.M., Gisselmann G., Zhang W., Dooley R., Stortkuhl K., Hatt H.;
RT "Odorant receptor heterodimerization in the olfactory system of Drosophila
RT melanogaster.";
RL Nat. Neurosci. 8:15-17(2005).
RN [10]
RP FUNCTION.
RX PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
RA Hallem E.A., Carlson J.R.;
RT "Coding of odors by a receptor repertoire.";
RL Cell 125:143-160(2006).
RN [11]
RP FUNCTION.
RX PubMed=17103386; DOI=10.1002/neu.20333;
RA Pelz D., Roeske T., Syed Z., de Bruyne M., Galizia C.G.;
RT "The molecular receptive range of an olfactory receptor in vivo (Drosophila
RT melanogaster Or22a).";
RL J. Neurobiol. 66:1544-1563(2006).
RN [12]
RP FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
RX PubMed=16402857; DOI=10.1371/journal.pbio.0040020;
RA Benton R., Sachse S., Michnick S.W., Vosshall L.B.;
RT "Atypical membrane topology and heteromeric function of Drosophila odorant
RT receptors in vivo.";
RL PLoS Biol. 4:E20-E20(2006).
RN [13]
RP FUNCTION.
RX PubMed=16919756; DOI=10.1016/j.jneumeth.2006.07.005;
RA Kiely A., Authier A., Kralicek A.V., Warr C.G., Newcomb R.D.;
RT "Functional analysis of a Drosophila melanogaster olfactory receptor
RT expressed in Sf9 cells.";
RL J. Neurosci. Methods 159:189-194(2007).
RN [14]
RP FUNCTION, AND INTERACTION WITH ORCO.
RX PubMed=18408711; DOI=10.1038/nature06861;
RA Wicher D., Schaefer R., Bauernfeind R., Stensmyr M.C., Heller R.,
RA Heinemann S.H., Hansson B.S.;
RT "Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-
RT activated cation channels.";
RL Nature 452:1007-1011(2008).
RN [15]
RP FUNCTION.
RX PubMed=22038943; DOI=10.1093/chemse/bjr097;
RA Richgels P.K., Rollmann S.M.;
RT "Genetic variation in odorant receptors contributes to variation in
RT olfactory behavior in a natural population of Drosophila melanogaster.";
RL Chem. Senses 37:229-240(2012).
RN [16]
RP FUNCTION.
RX PubMed=23315042; DOI=10.1093/chemse/bjs138;
RA Munch D., Schmeichel B., Silbering A.F., Galizia C.G.;
RT "Weaker ligands can dominate an odor blend due to syntopic interactions.";
RL Chem. Senses 38:293-304(2013).
RN [17]
RP INTERACTION WITH ORCO AND SNMP1, AND SUBCELLULAR LOCATION.
RX PubMed=23196131; DOI=10.1016/j.ibmb.2012.11.002;
RA German P.F., van der Poel S., Carraher C., Kralicek A.V., Newcomb R.D.;
RT "Insights into subunit interactions within the insect olfactory receptor
RT complex using FRET.";
RL Insect Biochem. Mol. Biol. 43:138-145(2013).
CC -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. The odorant receptor repertoire
CC encodes a large collection of odor stimuli that vary widely in
CC identity, intensity, and duration. Involved in the behavioral responses
CC ethyl butyrate and to esters in more general. Complexes with Orco to
CC form odorant-sensing units, providing sensitive and prolonged odorant
CC signaling and calcium permeability. They are necessary and sufficient
CC to promote functional reconstitution of odor-evoked signaling in
CC sensory neurons that normally respond only to carbon dioxide.
CC {ECO:0000269|PubMed:12628173, ECO:0000269|PubMed:15592462,
CC ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:16615896,
CC ECO:0000269|PubMed:16919756, ECO:0000269|PubMed:17103386,
CC ECO:0000269|PubMed:18408711, ECO:0000269|PubMed:22038943,
CC ECO:0000269|PubMed:23315042}.
CC -!- SUBUNIT: Interacts with Orco, via conserved C-terminal cytoplasmic
CC loops. Complexes exist early in the endomembrane system in olfactory
CC sensory neurons (OSNs), coupling these complexes to the conserved
CC ciliary trafficking pathway. Interacts with snmp1.
CC {ECO:0000269|PubMed:15592462, ECO:0000269|PubMed:16402857,
CC ECO:0000269|PubMed:18408711, ECO:0000269|PubMed:23196131}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23196131};
CC Multi-pass membrane protein {ECO:0000269|PubMed:23196131}.
CC -!- TISSUE SPECIFICITY: Expressed with Orco in 17-20 sensory neurons on the
CC medial-proximal edge of the antenna. Expressed in the ab3A neuron which
CC responds to ethyl butyrate. {ECO:0000269|PubMed:10069338,
CC ECO:0000269|PubMed:10089887, ECO:0000269|PubMed:10458908,
CC ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:12628173,
CC ECO:0000269|PubMed:15592462, ECO:0000269|PubMed:16402857}.
CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC odorant receptors appears to be an insect-specific solution for odor
CC recognition, making the OR/Orco complex an attractive target for the
CC development of highly selective insect repellents to disrupt olfactory-
CC mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC OR currents are independent of known G-protein-coupled second messenger
CC pathways.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC subfamily. {ECO:0000305}.
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DR EMBL; FM212142; CAR79041.1; -; Genomic_DNA.
DR EMBL; FM212143; CAR79043.1; -; Genomic_DNA.
DR EMBL; FM212144; CAR79045.1; -; Genomic_DNA.
DR EMBL; FM212145; CAR79047.1; -; Genomic_DNA.
DR EMBL; FM212146; CAR79049.1; -; Genomic_DNA.
DR EMBL; FM212147; CAR79051.1; -; Genomic_DNA.
DR EMBL; FM212148; CAR79053.1; -; Genomic_DNA.
DR EMBL; FM212149; CAR79055.1; -; Genomic_DNA.
DR EMBL; FM212150; CAR79057.1; -; Genomic_DNA.
DR EMBL; FM212151; CAR79059.1; -; Genomic_DNA.
DR EMBL; FM212152; CAR79061.1; -; Genomic_DNA.
DR EMBL; FM212153; CAR79063.1; -; Genomic_DNA.
DR EMBL; FM212154; CAR79065.1; -; Genomic_DNA.
DR EMBL; FM212155; CAR79067.1; -; Genomic_DNA.
DR EMBL; FM212156; CAR79069.1; -; Genomic_DNA.
DR EMBL; FM212157; CAR79071.1; -; Genomic_DNA.
DR EMBL; FM212158; CAR79073.1; -; Genomic_DNA.
DR EMBL; FM212159; CAR79075.1; -; Genomic_DNA.
DR EMBL; FM212160; CAR79077.1; -; Genomic_DNA.
DR EMBL; FM212161; CAR79079.1; -; Genomic_DNA.
DR EMBL; FM212162; CAR79081.1; -; Genomic_DNA.
DR EMBL; FM212163; CAR79083.1; -; Genomic_DNA.
DR EMBL; FM212164; CAR79085.1; -; Genomic_DNA.
DR EMBL; FM212165; CAR79087.1; -; Genomic_DNA.
DR EMBL; FM212166; CAR79089.1; -; Genomic_DNA.
DR EMBL; FM212167; CAR79091.1; -; Genomic_DNA.
DR EMBL; FM212168; CAR79093.1; -; Genomic_DNA.
DR EMBL; FM212169; CAR79095.1; -; Genomic_DNA.
DR EMBL; FM212170; CAR79097.1; -; Genomic_DNA.
DR EMBL; FM212171; CAR79099.1; -; Genomic_DNA.
DR EMBL; FM212172; CAR79101.1; -; Genomic_DNA.
DR EMBL; FM212173; CAR79103.1; -; Genomic_DNA.
DR EMBL; FM212174; CAR79105.1; -; Genomic_DNA.
DR EMBL; FM212175; CAR79107.1; -; Genomic_DNA.
DR EMBL; FM212176; CAR79109.1; -; Genomic_DNA.
DR EMBL; FM212177; CAR79111.1; -; Genomic_DNA.
DR EMBL; FM212178; CAR79113.1; -; Genomic_DNA.
DR EMBL; FM212204; CAR79364.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF51364.1; -; Genomic_DNA.
DR EMBL; AF127923; AAD26358.2; -; mRNA.
DR RefSeq; NP_523453.1; NM_078729.3.
DR AlphaFoldDB; P81909; -.
DR SMR; P81909; -.
DR BioGRID; 59579; 5.
DR DIP; DIP-20484N; -.
DR IntAct; P81909; 3.
DR STRING; 7227.FBpp0077541; -.
DR TCDB; 1.A.69.1.1; the heteromeric odorant receptor channel (horc) family.
DR PaxDb; P81909; -.
DR EnsemblMetazoa; FBtr0077873; FBpp0077541; FBgn0026398.
DR GeneID; 33335; -.
DR KEGG; dme:Dmel_CG12193; -.
DR CTD; 33335; -.
DR FlyBase; FBgn0026398; Or22a.
DR VEuPathDB; VectorBase:FBgn0026398; -.
DR eggNOG; ENOG502R7K0; Eukaryota.
DR GeneTree; ENSGT00540000073151; -.
DR HOGENOM; CLU_033399_8_0_1; -.
DR InParanoid; P81909; -.
DR OMA; YILWGIF; -.
DR OrthoDB; 745380at2759; -.
DR PhylomeDB; P81909; -.
DR BioGRID-ORCS; 33335; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33335; -.
DR PRO; PR:P81909; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0026398; Expressed in adult olfactory receptor neuron Or22 (Drosophila) and 1 other tissue.
DR ExpressionAtlas; P81909; baseline and differential.
DR Genevisible; P81909; DM.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0032590; C:dendrite membrane; IDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; HDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0071683; C:sensory dendrite; IDA:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:FlyBase.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; HDA:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; IMP:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IMP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..397
FT /note="Odorant receptor 22a"
FT /id="PRO_0000174232"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..280
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..304
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VARIANT 8
FT /note="H -> Y (in strain: MA74)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 59
FT /note="M -> I (in strain: NC1b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 67
FT /note="I -> M (in strain: MA43 and MA74)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 93
FT /note="M -> V (in strain: NC1b and NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 100
FT /note="C -> S (in strain: CN1, CN13, CN18, CN21, CN29,
FT CN45, CN51, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35,
FT LA4, MA21, MA24, NC1b, NC100b, NC37a, NC84a, NC89a and
FT NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 102
FT /note="F -> L (in strain: NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 196
FT /note="E -> A (in strain: CN1, CN13, CN18, CN21, CN28,
FT CN29, CN45, CN51, LA120, LA128, LA13, LA15, LA25, LA3,
FT LA32, LA34, LA35, LA4, LA6, LA9, MA21, MA24, NC1b, NC100b,
FT NC16a, NC37a, NC84a, NC89a and NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 201
FT /note="D -> E (in strain: NC1b and NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 220
FT /note="S -> N (in strain: CN14)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 292
FT /note="T -> S (in strain: CN13)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 328
FT /note="S -> A (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 329
FT /note="N -> D (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 330
FT /note="C -> S (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 359
FT /note="T -> I (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 375
FT /note="A -> N (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 382
FT /note="S -> T (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 385
FT /note="T -> A (in strain: NC1b and NC97a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 386
FT /note="V -> I (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 387
FT /note="I -> V (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 395
FT /note="R -> K (in strain: LA6)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT CONFLICT 256
FT /note="D -> SIPFLFINGLFLFLS (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 376..397
FT /note="MVKLAFSVVTVIKQFNLAERFQ -> VGVNILDISLILHLF (in Ref.
FT 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 46754 MW; E9D20EF06E69E883 CRC64;
MLSKFFPHIK EKPLSERVKS RDAFIYLDRV MWSFGWTEPE NKRWILPYKL WLAFVNIVML
ILLPISISIE YLHRFKTFSA GEFLSSLEIG VNMYGSSFKC AFTLIGFKKR QEAKVLLDQL
DKRCLSDKER STVHRYVAMG NFFDILYHIF YSTFVVMNFP YFLLERRHAW RMYFPYIDSD
EQFYISSIAE CFLMTEAIYM DLCTDVCPLI SMLMARCHIS LLKQRLRNLR SKPGRTEDEY
LEELTECIRD HRLLLDYVDA LRPVFSGTIF VQFLLIGTVL GLSMINLMFF STFWTGVATC
LFMFDVSMET FPFCYLCNMI IDDCQEMSNC LFQSDWTSAD RRYKSTLVYF LHNLQQPITL
TAGGVFPISM QTNLAMVKLA FSVVTVIKQF NLAERFQ
