OR22B_DROME
ID OR22B_DROME Reviewed; 397 AA.
AC P81910; B7VC06; B7VC10; B7VC50; B7VC52; B7VC62; B7VC68; B7VC76; B7VC81;
AC B7VC83; B7VC85; B7VC86; B7VC87; B7VC91; B7VC99; B7VCA1; B7VCA6; Q9U6X6;
AC Q9VQ19;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Odorant receptor 22b;
GN Name=Or22b; Synonyms=AN12, DOR22A.2, dor67, Or22A.2; ORFNames=CG4231;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R; TISSUE=Antenna;
RX PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
RA Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RT "A spatial map of olfactory receptor expression in the Drosophila
RT antenna.";
RL Cell 96:725-736(1999).
RN [2]
RP SEQUENCE REVISION TO 58.
RA Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10458908; DOI=10.1006/geno.1999.5894;
RA Gao Q., Chess A.;
RT "Identification of candidate Drosophila olfactory receptors from genomic
RT DNA sequence.";
RL Genomics 60:31-39(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-3; LYS-4; ILE-25;
RP LEU-30; GLU-38; ILE-45; PRO-47; ALA-69; LEU-87; GLU-88; ASP-92; VAL-93;
RP CYS-101; PHE-102; GLU-111; ARG-126; ALA-140; LEU-150; PHE-156; THR-157;
RP VAL-167; MET-194; LEU-196; ALA-201; LEU-213; MET-214; SER-220; MET-235;
RP THR-245; ASN-256; ARG-267; VAL-278; GLU-309; SER-313; SER-341; ILE-354 AND
RP MET-387.
RC STRAIN=CN1, CN13, CN14, CN18, CN21, CN28, CN29, CN3, CN43, CN45, CN46,
RC CN51, LA108, LA116, LA120, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35,
RC LA4, LA9, MA13, MA18, MA21, MA24, MA43, MA45, MA48, MA50, MA7, MA74, MA8,
RC MW25, MW27, MW29, MW3, MW32, MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC100b,
RC NC10b, NC16a, NC1b, NC21a, NC37a, NC52a, NC62a, NC73a, NC79b, NC84a, NC88a,
RC NC89a, and NC97a;
RX PubMed=18922763; DOI=10.1093/molbev/msn227;
RA Aguade M.;
RT "Nucleotide and copy-number polymorphism at the odorant receptor genes
RT Or22a and Or22b in Drosophila melanogaster.";
RL Mol. Biol. Evol. 26:61-70(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [7]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RC TISSUE=Antenna;
RX PubMed=10069338; DOI=10.1016/s0896-6273(00)81093-4;
RA Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
RT "A novel family of divergent seven-transmembrane proteins: candidate
RT odorant receptors in Drosophila.";
RL Neuron 22:327-338(1999).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA Vosshall L.B., Wong A.M., Axel R.;
RT "An olfactory sensory map in the fly brain.";
RL Cell 102:147-159(2000).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12628173; DOI=10.1016/s0896-6273(03)00094-1;
RA Dobritsa A.A., van der Goes van Naters W., Warr C.G., Steinbrecht R.A.,
RA Carlson J.R.;
RT "Integrating the molecular and cellular basis of odor coding in the
RT Drosophila antenna.";
RL Neuron 37:827-841(2003).
RN [10]
RP FUNCTION, INTERACTION WITH ORCO, AND TISSUE SPECIFICITY.
RX PubMed=16402857; DOI=10.1371/journal.pbio.0040020;
RA Benton R., Sachse S., Michnick S.W., Vosshall L.B.;
RT "Atypical membrane topology and heteromeric function of Drosophila odorant
RT receptors in vivo.";
RL PLoS Biol. 4:E20-E20(2006).
RN [11]
RP FUNCTION.
RX PubMed=22038943; DOI=10.1093/chemse/bjr097;
RA Richgels P.K., Rollmann S.M.;
RT "Genetic variation in odorant receptors contributes to variation in
RT olfactory behavior in a natural population of Drosophila melanogaster.";
RL Chem. Senses 37:229-240(2012).
CC -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. The odorant receptor repertoire
CC encodes a large collection of odor stimuli that vary widely in
CC identity, intensity, and duration. Involved in the behavioral responses
CC to esters. Complexes with Orco to form odorant-sensing units, providing
CC sensitive and prolonged odorant signaling and calcium permeability.
CC They are necessary and sufficient to promote functional reconstitution
CC of odor-evoked signaling in sensory neurons that normally respond only
CC to carbon dioxide. {ECO:0000269|PubMed:12628173,
CC ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:22038943}.
CC -!- SUBUNIT: Interacts with Orco, via conserved C-terminal cytoplasmic
CC loops. Complexes exist early in the endomembrane system in olfactory
CC sensory neurons (OSNs), coupling these complexes to the conserved
CC ciliary trafficking pathway. {ECO:0000269|PubMed:16402857}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed with Orco in 20-22 sensory neurons on the
CC medial-proximal edge of the antenna. This expression pattern matches
CC the distribution of the large sensilla basiconica. Expression is first
CC seen at 60 hours APF in a subset of cells restricted to a subregion of
CC the developing antenna. Expression continues throughout antennal
CC development. Expressed in the ab3A neuron which responds to ethyl
CC butyrate. {ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10089887,
CC ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:12628173,
CC ECO:0000269|PubMed:16402857}.
CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC odorant receptors appears to be an insect-specific solution for odor
CC recognition, making the OR/Orco complex an attractive target for the
CC development of highly selective insect repellents to disrupt olfactory-
CC mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC OR currents are independent of known G-protein-coupled second messenger
CC pathways.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAR79088.1; Type=Miscellaneous discrepancy; Note=Intron retention and rearrangement of DNA.; Evidence={ECO:0000305};
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DR EMBL; AF127924; AAD26359.2; -; mRNA.
DR EMBL; FM212142; CAR79042.1; -; Genomic_DNA.
DR EMBL; FM212143; CAR79044.1; -; Genomic_DNA.
DR EMBL; FM212144; CAR79046.1; -; Genomic_DNA.
DR EMBL; FM212145; CAR79048.1; -; Genomic_DNA.
DR EMBL; FM212146; CAR79050.1; -; Genomic_DNA.
DR EMBL; FM212147; CAR79052.1; -; Genomic_DNA.
DR EMBL; FM212148; CAR79054.1; -; Genomic_DNA.
DR EMBL; FM212149; CAR79056.1; -; Genomic_DNA.
DR EMBL; FM212150; CAR79058.1; -; Genomic_DNA.
DR EMBL; FM212151; CAR79060.1; -; Genomic_DNA.
DR EMBL; FM212152; CAR79062.1; -; Genomic_DNA.
DR EMBL; FM212153; CAR79064.1; -; Genomic_DNA.
DR EMBL; FM212154; CAR79066.1; -; Genomic_DNA.
DR EMBL; FM212155; CAR79068.1; -; Genomic_DNA.
DR EMBL; FM212156; CAR79070.1; -; Genomic_DNA.
DR EMBL; FM212157; CAR79072.1; -; Genomic_DNA.
DR EMBL; FM212158; CAR79074.1; -; Genomic_DNA.
DR EMBL; FM212159; CAR79076.1; -; Genomic_DNA.
DR EMBL; FM212160; CAR79078.1; -; Genomic_DNA.
DR EMBL; FM212161; CAR79080.1; -; Genomic_DNA.
DR EMBL; FM212162; CAR79082.1; -; Genomic_DNA.
DR EMBL; FM212163; CAR79084.1; -; Genomic_DNA.
DR EMBL; FM212164; CAR79086.1; -; Genomic_DNA.
DR EMBL; FM212165; CAR79088.1; ALT_SEQ; Genomic_DNA.
DR EMBL; FM212166; CAR79090.1; -; Genomic_DNA.
DR EMBL; FM212167; CAR79092.1; -; Genomic_DNA.
DR EMBL; FM212168; CAR79094.1; -; Genomic_DNA.
DR EMBL; FM212169; CAR79096.1; -; Genomic_DNA.
DR EMBL; FM212170; CAR79098.1; -; Genomic_DNA.
DR EMBL; FM212171; CAR79100.1; -; Genomic_DNA.
DR EMBL; FM212172; CAR79102.1; -; Genomic_DNA.
DR EMBL; FM212173; CAR79104.1; -; Genomic_DNA.
DR EMBL; FM212174; CAR79106.1; -; Genomic_DNA.
DR EMBL; FM212175; CAR79108.1; -; Genomic_DNA.
DR EMBL; FM212176; CAR79110.1; -; Genomic_DNA.
DR EMBL; FM212177; CAR79112.1; -; Genomic_DNA.
DR EMBL; FM212178; CAR79114.1; -; Genomic_DNA.
DR EMBL; FM212180; CAR79340.1; -; Genomic_DNA.
DR EMBL; FM212181; CAR79341.1; -; Genomic_DNA.
DR EMBL; FM212182; CAR79342.1; -; Genomic_DNA.
DR EMBL; FM212183; CAR79343.1; -; Genomic_DNA.
DR EMBL; FM212184; CAR79344.1; -; Genomic_DNA.
DR EMBL; FM212185; CAR79345.1; -; Genomic_DNA.
DR EMBL; FM212186; CAR79346.1; -; Genomic_DNA.
DR EMBL; FM212187; CAR79347.1; -; Genomic_DNA.
DR EMBL; FM212188; CAR79348.1; -; Genomic_DNA.
DR EMBL; FM212189; CAR79349.1; -; Genomic_DNA.
DR EMBL; FM212190; CAR79350.1; -; Genomic_DNA.
DR EMBL; FM212191; CAR79351.1; -; Genomic_DNA.
DR EMBL; FM212192; CAR79352.1; -; Genomic_DNA.
DR EMBL; FM212193; CAR79353.1; -; Genomic_DNA.
DR EMBL; FM212194; CAR79354.1; -; Genomic_DNA.
DR EMBL; FM212195; CAR79355.1; -; Genomic_DNA.
DR EMBL; FM212196; CAR79356.1; -; Genomic_DNA.
DR EMBL; FM212197; CAR79357.1; -; Genomic_DNA.
DR EMBL; FM212198; CAR79358.1; -; Genomic_DNA.
DR EMBL; FM212199; CAR79359.1; -; Genomic_DNA.
DR EMBL; FM212200; CAR79360.1; -; Genomic_DNA.
DR EMBL; FM212201; CAR79361.1; -; Genomic_DNA.
DR EMBL; FM212202; CAR79362.1; -; Genomic_DNA.
DR EMBL; FM212203; CAR79363.1; -; Genomic_DNA.
DR EMBL; FM212205; CAR79365.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF51363.1; -; Genomic_DNA.
DR RefSeq; NP_477425.1; NM_058077.3.
DR AlphaFoldDB; P81910; -.
DR SMR; P81910; -.
DR BioGRID; 59580; 1.
DR IntAct; P81910; 1.
DR STRING; 7227.FBpp0077542; -.
DR TCDB; 1.A.69.1.1; the heteromeric odorant receptor channel (horc) family.
DR PaxDb; P81910; -.
DR EnsemblMetazoa; FBtr0077874; FBpp0077542; FBgn0026397.
DR GeneID; 33336; -.
DR KEGG; dme:Dmel_CG4231; -.
DR CTD; 33336; -.
DR FlyBase; FBgn0026397; Or22b.
DR VEuPathDB; VectorBase:FBgn0026397; -.
DR eggNOG; ENOG502R7K0; Eukaryota.
DR GeneTree; ENSGT00540000073151; -.
DR HOGENOM; CLU_033399_8_0_1; -.
DR InParanoid; P81910; -.
DR OMA; CNMIMDD; -.
DR OrthoDB; 745330at2759; -.
DR PhylomeDB; P81910; -.
DR BioGRID-ORCS; 33336; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33336; -.
DR PRO; PR:P81910; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0026397; Expressed in antenna and 2 other tissues.
DR ExpressionAtlas; P81910; differential.
DR Genevisible; P81910; DM.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0032590; C:dendrite membrane; IDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IEP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..397
FT /note="Odorant receptor 22b"
FT /id="PRO_0000174233"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VARIANT 3
FT /note="S -> G (in strain: MA7)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 4
FT /note="Q -> K (in strain: LA116, MA18, MA45, MA48, MA50,
FT MA7, MA8, MW25, MW29, MW3, MW32, MW37, MW44, MW46, MW56,
FT MW6, MW7, MW9, NC21a, NC52a, NC62a, NC73a and NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 25
FT /note="V -> I (in strain: LA116, MA13, MA18, MA43, MA45,
FT MA48, MA50, MA7, MA74, MA8, MW25, MW27, MW29, MW3, MW32,
FT MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC21a, NC52a, NC62a,
FT NC73a and NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 30
FT /note="V -> L (in strain: NC52a and NC73a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 38
FT /note="V -> E (in strain: NC21a, NC52a, NC62a, NC73a and
FT NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 45
FT /note="D -> I (in strain: LA116, MA45, MA50, MW37, MW6 and
FT MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 47
FT /note="H -> P (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 69
FT /note="V -> A (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 87
FT /note="I -> L (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 88
FT /note="Q -> E (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 92
FT /note="N -> D (in strain: NC21a, NC52a, NC62a, NC73a and
FT NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 93
FT /note="M -> V (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 101
FT /note="Y -> C (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 102
FT /note="L -> F (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 111
FT /note="Q -> E (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 126
FT /note="C -> R (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 140
FT /note="G -> A (in strain: LA9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 150
FT /note="A -> L (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 156
FT /note="I -> F (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 157
FT /note="S -> T (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 167
FT /note="I -> V (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 194
FT /note="R -> M (in strain: LA116, MA13, MA18, MA43, MA45,
FT MA48, MA50, MA7, MA74, MA8, MW25, MW27, MW29, MW3, MW32,
FT MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC21a, NC52a, NC62a,
FT NC73a and NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 196
FT /note="W -> L (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 201
FT /note="D -> A (in strain: NC21a, NC52a, NC62a, NC73a and
FT NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 213
FT /note="V -> L (in strain: LA116, MA45, MA50, MW37, MW6,
FT MW9, NC52a and NC73a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 214
FT /note="I -> M (in strain: LA116, MA45, MA50, MW37, MW6 and
FT MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 220
FT /note="T -> S (in strain: LA116, MA45, MA50, MW37, MW6 and
FT MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 235
FT /note="R -> M (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 245
FT /note="A -> T (in strain: LA116, MA45, MA50, MW37, MW6 and
FT MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 256
FT /note="D -> N (in strain: MW44)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 267
FT /note="G -> R (in strain: MA45, MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 278
FT /note="I -> V (in strain: LA108 and LA120)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 309
FT /note="Q -> E (in strain: LA116, LA25, LA4, MA24, MA45,
FT MA50, MW37, MW6 and MW9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 313
FT /note="F -> S (in strain: NC16a)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 341
FT /note="R -> S (in strain: LA116)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 354
FT /note="L -> I (in strain: NC52a, NC73a and NC79b)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT VARIANT 387
FT /note="V -> M (in strain: LA9)"
FT /evidence="ECO:0000269|PubMed:18922763"
FT CONFLICT 52..60
FT /note="STFVTLLIF -> LAFVNIVML (in Ref. 4; CAR79365)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="L -> V (in Ref. 1; AAD26359)"
FT /evidence="ECO:0000305"
FT CONFLICT 67..73
FT /note="VSVEYIQ -> ISIEYLH (in Ref. 4; CAR79365)"
FT /evidence="ECO:0000305"
FT CONFLICT 129..133
FT /note="ERTIV -> DRSII (in Ref. 4; CAR79363/CAR79362/
FT CAR79361/CAR79351/CAR79350)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="D -> TICFDKFFYLPYFFS (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 376..397
FT /note="MVKLAFTVVTIVKQFNLAEKFQ -> VSINQYEL (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 46402 MW; CE0CDA1C5EFE11DA CRC64;
MLSQFFPHIK EKPLSERVKS RDAFVYLDRV MWSFGWTVPE NKRWDLHYKL WSTFVTLLIF
ILLPISVSVE YIQRFKTFSA GEFLSSIQIG VNMYGSSFKS YLTMMGYKKR QEAKMSLDEL
DKRCVCDEER TIVHRHVALG NFCYIFYHIA YTSFLISNFL SFIMKRIHAW RMYFPYVDPE
KQFYISSIAE VILRGWAVFM DLCTDVCPLI SMVIARCHIT LLKQRLRNLR SEPGRTEDEY
LKELADCVRD HRLILDYVDA LRSVFSGTIF VQFLLIGIVL GLSMINIMFF STLSTGVAVV
LFMSCVSMQT FPFCYLCNMI MDDCQEMADS LFQSDWTSAD RRYKSTLVYF LHNLQQPIIL
TAGGVFPISM QTNLNMVKLA FTVVTIVKQF NLAEKFQ
