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OR23A_DROME
ID   OR23A_DROME             Reviewed;         379 AA.
AC   P81912;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1999, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Odorant receptor 23a;
GN   Name=Or23a; Synonyms=AN5, DOR23A.1, dor64, Or23A.1; ORFNames=CG9880;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Oregon-R; TISSUE=Antenna;
RX   PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
RA   Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RT   "A spatial map of olfactory receptor expression in the Drosophila
RT   antenna.";
RL   Cell 96:725-736(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=10458908; DOI=10.1006/geno.1999.5894;
RA   Gao Q., Chess A.;
RT   "Identification of candidate Drosophila olfactory receptors from genomic
RT   DNA sequence.";
RL   Genomics 60:31-39(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=10069338; DOI=10.1016/s0896-6273(00)81093-4;
RA   Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
RT   "A novel family of divergent seven-transmembrane proteins: candidate
RT   odorant receptors in Drosophila.";
RL   Neuron 22:327-338(1999).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA   Vosshall L.B., Wong A.M., Axel R.;
RT   "An olfactory sensory map in the fly brain.";
RL   Cell 102:147-159(2000).
RN   [7]
RP   FUNCTION.
RX   PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
RA   Hallem E.A., Carlson J.R.;
RT   "Coding of odors by a receptor repertoire.";
RL   Cell 125:143-160(2006).
CC   -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC       behavior, depending on its substrates. The odorant receptor repertoire
CC       encodes a large collection of odor stimuli that vary widely in
CC       identity, intensity, and duration. May form a complex with Orco to form
CC       odorant-sensing units, providing sensitive and prolonged odorant
CC       signaling and calcium permeability. {ECO:0000269|PubMed:16615896}.
CC   -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC       system in olfactory sensory neurons (OSNs), coupling these complexes to
CC       the conserved ciliary trafficking pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in 10-40 sensory cells in the third
CC       antenna segment and in the maxillary palp.
CC       {ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10089887,
CC       ECO:0000269|PubMed:10458908, ECO:0000269|PubMed:10943836}.
CC   -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC       odorant receptors appears to be an insect-specific solution for odor
CC       recognition, making the OR/Orco complex an attractive target for the
CC       development of highly selective insect repellents to disrupt olfactory-
CC       mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC       OR currents are independent of known G-protein-coupled second messenger
CC       pathways.
CC   -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC       Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF127925; AAD26360.1; -; mRNA.
DR   EMBL; AE014134; AAF51230.3; -; Genomic_DNA.
DR   RefSeq; NP_523458.3; NM_078734.4.
DR   AlphaFoldDB; P81912; -.
DR   SMR; P81912; -.
DR   STRING; 7227.FBpp0077382; -.
DR   GlyGen; P81912; 1 site.
DR   PaxDb; P81912; -.
DR   PRIDE; P81912; -.
DR   EnsemblMetazoa; FBtr0077698; FBpp0077382; FBgn0026395.
DR   GeneID; 33450; -.
DR   KEGG; dme:Dmel_CG9880; -.
DR   CTD; 33450; -.
DR   FlyBase; FBgn0026395; Or23a.
DR   VEuPathDB; VectorBase:FBgn0026395; -.
DR   eggNOG; ENOG502RTKY; Eukaryota.
DR   GeneTree; ENSGT00540000073151; -.
DR   HOGENOM; CLU_033399_8_1_1; -.
DR   InParanoid; P81912; -.
DR   OMA; CIRDQNA; -.
DR   OrthoDB; 745330at2759; -.
DR   PhylomeDB; P81912; -.
DR   BioGRID-ORCS; 33450; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 33450; -.
DR   PRO; PR:P81912; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0026395; Expressed in sensillum trichodeum of antennal segment 3 (Drosophila) and 8 other tissues.
DR   Genevisible; P81912; DM.
DR   GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR   GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; HDA:FlyBase.
DR   GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR   GO; GO:0004984; F:olfactory receptor activity; HDA:FlyBase.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; HDA:FlyBase.
DR   GO; GO:0007608; P:sensory perception of smell; IEP:FlyBase.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004117; 7tm6_olfct_rcpt.
DR   PANTHER; PTHR21137; PTHR21137; 1.
DR   Pfam; PF02949; 7tm_6; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW   Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..379
FT                   /note="Odorant receptor 23a"
FT                   /id="PRO_0000174235"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..280
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        302..340
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        362..379
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  43793 MW;  4DC3E1D9F4C8BBCF CRC64;
     MKLSETLKID YFRVQLNAWR ICGALDLSEG RYWSWSMLLC ILVYLPTPML LRGVYSFEDP
     VENNFSLSLT VTSLSNLMKF CMYVAQLTKM VEVQSLIGQL DARVSGESQS ERHRNMTEHL
     LRMSKLFQIT YAVVFIIAAV PFVFETELSL PMPMWFPFDW KNSMVAYIGA LVFQEIGYVF
     QIMQCFAADS FPPLVLYLIS EQCQLLILRI SEIGYGYKTL EENEQDLVNC IRDQNALYRL
     LDVTKSLVSY PMMVQFMVIG INIAITLFVL IFYVETLYDR IYYLCFLLGI TVQTYPLCYY
     GTMVQESFAE LHYAVFCSNW VDQSASYRGH MLILAERTKR MQLLLAGNLV PIHLSTYVAC
     WKGAYSFFTL MADRDGLGS
 
 
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