OR2A1_HUMAN
ID OR2A1_HUMAN Reviewed; 310 AA.
AC Q8NGT9; Q6IF44; Q96R46;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 2A1/2A42;
DE AltName: Full=Olfactory receptor OR7-16;
DE AltName: Full=Olfactory receptor OR7-19;
GN Name=OR2A1;
GN and
GN Name=OR2A42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A1";
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR2A1/term:OR2A1/type:keyword";
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DR EMBL; AB065692; BAC05915.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF399597; AAK95082.1; -; Genomic_DNA.
DR EMBL; BK004217; DAA04615.1; -; Genomic_DNA.
DR EMBL; BK004418; DAA04816.1; -; Genomic_DNA.
DR CCDS; CCDS43673.1; -.
DR CCDS; CCDS56515.1; -.
DR RefSeq; NP_001001802.2; NM_001001802.2.
DR RefSeq; NP_001005287.1; NM_001005287.1.
DR AlphaFoldDB; Q8NGT9; -.
DR SMR; Q8NGT9; -.
DR STRING; 9606.ENSP00000375334; -.
DR GlyGen; Q8NGT9; 1 site.
DR iPTMnet; Q8NGT9; -.
DR PhosphoSitePlus; Q8NGT9; -.
DR BioMuta; OR2A42; -.
DR DMDM; 38372771; -.
DR MassIVE; Q8NGT9; -.
DR PaxDb; Q8NGT9; -.
DR PeptideAtlas; Q8NGT9; -.
DR PRIDE; Q8NGT9; -.
DR Antibodypedia; 32713; 73 antibodies from 17 providers.
DR Antibodypedia; 72718; 30 antibodies from 7 providers.
DR DNASU; 402317; -.
DR Ensembl; ENST00000641044.2; ENSP00000493454.1; ENSG00000221970.4.
DR Ensembl; ENST00000641810.1; ENSP00000493333.1; ENSG00000212807.3.
DR GeneID; 346528; -.
DR GeneID; 402317; -.
DR KEGG; hsa:346528; -.
DR KEGG; hsa:402317; -.
DR MANE-Select; ENST00000641044.2; ENSP00000493454.1; NM_001005287.2; NP_001005287.1.
DR MANE-Select; ENST00000641810.1; ENSP00000493333.1; NM_001001802.3; NP_001001802.2.
DR UCSC; uc011kub.2; human.
DR CTD; 346528; -.
DR CTD; 402317; -.
DR GeneCards; OR2A1; -.
DR GeneCards; OR2A42; -.
DR HGNC; HGNC:8229; OR2A1.
DR HGNC; HGNC:31230; OR2A42.
DR HPA; ENSG00000212807; Tissue enhanced (choroid).
DR HPA; ENSG00000221970; Tissue enhanced (thyroid).
DR neXtProt; NX_Q8NGT9; -.
DR OpenTargets; ENSG00000212807; -.
DR PharmGKB; PA134971566; -.
DR VEuPathDB; HostDB:ENSG00000212807; -.
DR VEuPathDB; HostDB:ENSG00000221970; -.
DR eggNOG; ENOG502SIA2; Eukaryota.
DR GeneTree; ENSGT00940000153255; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGT9; -.
DR OMA; VNITYAC; -.
DR OrthoDB; 1018653at2759; -.
DR PhylomeDB; Q8NGT9; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGT9; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 346528; 61 hits in 589 CRISPR screens.
DR BioGRID-ORCS; 402317; 3 hits in 217 CRISPR screens.
DR GeneWiki; OR2A1; -.
DR Pharos; Q8NGT9; Tdark.
DR PRO; PR:Q8NGT9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NGT9; protein.
DR Bgee; ENSG00000212807; Expressed in sural nerve and 73 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 2A1/2A42"
FT /id="PRO_0000150459"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34714 MW; CE5E0170B025E871 CRC64;
MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL DSRLHTPMYF
FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT FLCLSFGHSE CLLLVLMSYD
RYVAICHPLR YSVIMTWRVC ITLAVTSWTC GSLLALAHVV LILRLPFSGP HEINHFFCEI
LSVLRLACAD TWLNQVVIFA ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC
SSHLCVVGLF FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL
RRALGKESHS
